Amygdala Retraining Program Improves Symptoms and Biology in Fibromyalgia - Health Rising
Ashok Gupta's Amygdala and Insula Retraining Program significantly improves symptoms in fibromyalgia and is more effective than relaxation therapy.
Combined use of Pregabalin and Memantine in Fibromyalgia Syndrome Treatment: A Novel Analgesic and Neuroprotective Strategy?
Memantine (an Alzheimer’s drug) slows loss of grey matter in brains of people with fibromyalgia. Also decreases pain.
New Treatment Target for Fibromyalgia: Inflammation in the Brain
Neuroinflammation in the brain as a therapeutic target
Modafinil goes well beyond addressing fatigue.
I take Nuvigil (armodafinil) which is an isomer of Provigil (modafinil), which was shown to reduce neuroinflammation. Nuvigil takes away a lot of my pain.
Modulating the immune response with the wake-promoting drug modafinil: A potential therapeutic approach for inflammatory disorders - PubMed
This would explain why the isomer of modafinil that I take, armodafinil, greatly reduces my pain
Caffeine and Modafinil Ameliorate the Neuroinflammation and Anxious Behavior in Rats during Sleep Deprivation by Inhibiting the Microglia Activation
Neuroinflammation being a factor, plus modafinil use. In my case, armodafinil works well for pain (Nuvigil).