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Modafinil Reduces Neuronal Pyroptosis and Cognitive Decline After Sleep Deprivation
Modafinil Reduces Neuronal Pyroptosis and Cognitive Decline After Sleep Deprivation
Sleep deprivation (SD) induces systemic inflammation that promotes neuronal pyroptosis. The purpose of this study was to investigate the effect of an antioxidant modafinil on neuronal pyroptosis and cognitive decline following SD. Using a mouse model ...
reduced proinflammatory factor (IL-1β, TNF-α, and IL-6) production, and increased the expression of anti-inflammatory factors (IL-10).
This probably speaks to its role in combating pain in FMS.
Modafinil treatment attenuated inflammasome activity and reduced neuronal pyroptosis involving the NLRP3/NLRP1/NLRC4-caspase-1-IL-1β pathway
IL-1β
IL-6
TNF-α
#research#modafinil#neuroinflammation#brain#inflammation#fibromyalgia#study
·ncbi.nlm.nih.gov·
Modafinil Reduces Neuronal Pyroptosis and Cognitive Decline After Sleep Deprivation
Evidence of both systemic inflammation and neuroinflammation in fibromyalgia patients, as assessed by a multiplex protein panel applied to the cerebrospinal fluid and to plasma
Evidence of both systemic inflammation and neuroinflammation in fibromyalgia patients, as assessed by a multiplex protein panel applied to the cerebrospinal fluid and to plasma
In addition to central hyperexcitability and impaired top–down modulation, chronic inflammation probably plays a role in the pathophysiology of fibromyalgia (FM). Indeed, on the basis of both animal experiments and human studies involving the ...
Evidence of both systemic inflammation and neuroinflammation in fibromyalgia patients, as assessed by a multiplex protein panel applied to the cerebrospinal fluid and to plasma
#study#inflammation#systemic inflammation#neuroinflammation#fibromyalgia#research
·ncbi.nlm.nih.gov·
Evidence of both systemic inflammation and neuroinflammation in fibromyalgia patients, as assessed by a multiplex protein panel applied to the cerebrospinal fluid and to plasma