Fibromyalgia Cutting Through the B.S.
Dr. Martin Rutherford, M.D. has fibromyalgia, and he discusses his experience and opinions.
Dr. Ginevra | Fibromyalgia
Dr. Ginevra is a leading expert in fibromyalgia. She also has fibromyalgia.
Passive transfer of fibromyalgia symptoms from patients to mice - PubMed
We can “give” fibromyalgia to mice by transferring fibromyalgia patients’ antibodies to them. Symptoms resolve when antibodies are taken away. Strongly suggests fibromyalgia has an autoimmune component.
Metformin and caloric restriction induce an AMPK-dependent restoration of mitochondrial dysfunction in fibroblasts from Fibromyalgia patients
Suggests metabolic syndrome involvement and mitochondrial dysfunction in fibromyalgia development
Hormonal Health and Wellness Inflammation & Low Dose Naltrexone in Cross Roads, TX | Cross Roads Hormonal Health & Wellness
Low Dose Naltrexone helping fibromyalgial pain.
Brain glial activation in fibromyalgia – A multi-site positron emission tomography investigation
More evidence suggesting autoimmune component in fibromyalgia
Evidence of both systemic inflammation and neuroinflammation in fibromyalgia patients, as assessed by a multiplex protein panel applied to the cerebrospinal fluid and to plasma - PubMed
Yes; and evidence can be found in cerebrospinal fluid, so we know there is neuroinflammation in fibromyalgia.
![Norepinephrine-evoked pain in fibromyalgia. A randomized pilot study [ISRCTN70707830]](https://rdl.ink/render/https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fcorehtml%2Fpmc%2Fpmcgifs%2Fpmc-card-share.jpg%3F_%3D0?width=92&height=&ar=&mode=&format=avif&dpr=2)
Norepinephrine-evoked pain in fibromyalgia. A randomized pilot study [ISRCTN70707830]
Norepinephrine-evoked pain was seen in 80 % of FM patients (95% confidence intervals 56.3 – 94.3%), in 30 % of rheumatoid arthritis patients and in 30 % of healthy controls (95% confidence intervals 11.9 – 54.3) (p < 0.05). Intensity of norepinephrine-evoked pain was greater in FM patients (mean ± SD 2.5 ± 2.5) when compared to rheumatoid arthritis patients (0.3 ± 0.7), and healthy controls (0.3 ± 0.8) p < 0.0001.
Central Role of Dopamine in Fibromyalgia
A review of the evidence that fibromyalgia is associated with a disruption of dopaminergic neurotransmission together with a discussion of its therapeutic implications.
Low-dose naltrexone for the treatment of fibromyalgia: protocol for a double-blind, randomized, placebo-controlled trial
To me, it says probable autoimmune component in fibromyalgia ; LDN is taken by people with autoimmune diseases, and fibromyalgia patients have success with it
Cetirizine and allopurinol as novel weapons against cellular autoimmune disorders - PubMed
Some people with autoimmune diseases take cetirizine
The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain
Fibromyalgia patients are having success with it; LDN has an immunomodulatory effect, and to me this also bolsters the case for an autoimmune component in fibromyalgia.
Modafinil goes well beyond addressing fatigue.
I take Nuvigil (armodafinil) which is an isomer of Provigil (modafinil), which was shown to reduce neuroinflammation. Nuvigil takes away a lot of my pain.
Modulating the immune response with the wake-promoting drug modafinil: A potential therapeutic approach for inflammatory disorders - PubMed
This would explain why the isomer of modafinil that I take, armodafinil, greatly reduces my pain
Caffeine and Modafinil Ameliorate the Neuroinflammation and Anxious Behavior in Rats during Sleep Deprivation by Inhibiting the Microglia Activation
Neuroinflammation being a factor, plus modafinil use. In my case, armodafinil works well for pain (Nuvigil).
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Is Fibromyalgia an Autoimmune Disease?
It has an autoimmune component. "that several autoantibodies were unusually high in people with FM"
MAO-A Inhibition by Metaxalone Reverts IL-1β-Induced Inflammatory Phenotype in Microglial Cells
Interesting that Metaxalone has this effect, and it works well for fibromyalgia. More suggestion that there is an autoimmune component.
I Beat Fibromyalgia And I’ll Tell You How
A blogger's diet.
The Link Between Fibromyalgia And Complex Trauma
Trauma suggested as a cause of fibromyalgia
Metformin and caloric restriction induce an AMPK-dependent restoration of mitochondrial dysfunction in fibroblasts from Fibromyalgia patients
Some suggest insulin resistance as a cause of fibromyalgia
Metformin and caloric restriction induce an AMPK-dependent restoration of mitochondrial dysfunction in fibroblasts from Fibromyalgia patients
Immunometabolic modulatory role of naltrexone in micro glial cells
Suggests fibromyalgia has An autoimmune component
Evidence of Mitochondrial Dysfunction in Fibromyalgia: Deviating Muscle Energy Metabolism Detected Using Microdialysis and Magnetic Resonance
Mitochondrial dysfunction involvement in fibromyalgia