Amygdala Retraining Program Improves Symptoms and Biology in Fibromyalgia - Health Rising
Ashok Gupta's Amygdala and Insula Retraining Program significantly improves symptoms in fibromyalgia and is more effective than relaxation therapy.
New Treatment Target for Fibromyalgia: Inflammation in the Brain
Neuroinflammation in the brain as a therapeutic target
Modafinil goes well beyond addressing fatigue.
I take Nuvigil (armodafinil) which is an isomer of Provigil (modafinil), which was shown to reduce neuroinflammation. Nuvigil takes away a lot of my pain.
Modulating the immune response with the wake-promoting drug modafinil: A potential therapeutic approach for inflammatory disorders - PubMed
This would explain why the isomer of modafinil that I take, armodafinil, greatly reduces my pain
Caffeine and Modafinil Ameliorate the Neuroinflammation and Anxious Behavior in Rats during Sleep Deprivation by Inhibiting the Microglia Activation
Neuroinflammation being a factor, plus modafinil use. In my case, armodafinil works well for pain (Nuvigil).