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Impact of mast cells in fibromyalgia and low-grade chronic inflammation: Can IL-37 play a role? - PubMed
Impact of mast cells in fibromyalgia and low-grade chronic inflammation: Can IL-37 play a role? - PubMed
Fibromyalgia (FM) is a disease characterized by chronic widespread pain, fatigue, aches, joint stiffness, depression, cognitive dysfunction, and nonrestorative sleep. In FM, neurotransmission and glial activation can occur with an increase in inflammatory cytokines and involvement of mast cells (MCs …
·pubmed.ncbi.nlm.nih.gov·
Impact of mast cells in fibromyalgia and low-grade chronic inflammation: Can IL-37 play a role? - PubMed
Accelerated Brain Gray Matter Loss in Fibromyalgia Patients: Premature Aging of the Brain?
Accelerated Brain Gray Matter Loss in Fibromyalgia Patients: Premature Aging of the Brain?
Fibromyalgia is an intractable widespread pain disorder that is most frequently diagnosed in women. It has traditionally been classified as either a musculoskeletal disease or a psychological disorder. Accumulating evidence now suggests that fibromyalgia may be associated with CNS dysfunction. In this study, we investigate anatomical changes in the brain associated with fibromyalgia. Using voxel-based morphometric analysis of magnetic resonance brain images, we examined the brains of 10 female fibromyalgia patients and 10 healthy controls. We found that fibromyalgia patients had significantly less total gray matter volume and showed a 3.3 times greater age-associated decrease in gray matter than healthy controls. The longer the individuals had had fibromyalgia, the greater the gray matter loss, with each year of fibromyalgia being equivalent to 9.5 times the loss in normal aging. In addition, fibromyalgia patients demonstrated significantly less gray matter density than healthy controls in several brain regions, including the cingulate, insular and medial frontal cortices, and parahippocampal gyri. The neuroanatomical changes that we see in fibromyalgia patients contribute additional evidence of CNS involvement in fibromyalgia. In particular, fibromyalgia appears to be associated with an acceleration of age-related changes in the very substance of the brain. Moreover, the regions in which we demonstrate objective changes may be functionally linked to core features of the disorder including affective disturbances and chronic widespread pain.
·jneurosci.org·
Accelerated Brain Gray Matter Loss in Fibromyalgia Patients: Premature Aging of the Brain?
The Link between Fibromyalgia Syndrome and Anger: A Systematic Review Revealing Research Gaps
The Link between Fibromyalgia Syndrome and Anger: A Systematic Review Revealing Research Gaps
Anger has been associated with increased pain perception, but its specific connection with Fibromyalgia Syndrome (FMS) has not yet been established in an integrated approach. Therefore, the present systematic review focuses on exploring this connection, ...
·ncbi.nlm.nih.gov·
The Link between Fibromyalgia Syndrome and Anger: A Systematic Review Revealing Research Gaps
DIFFERENTIAL DOPAMINE FUNCTION IN FIBROMYALGIA
DIFFERENTIAL DOPAMINE FUNCTION IN FIBROMYALGIA
Approximately 30% of Americans suffer from chronic pain disorders, such as fibromyalgia (FM), which can cause debilitating pain. Many pain-killing drugs prescribed for chronic pain disorders are highly addictive, have limited clinical efficacy, and do ...
·ncbi.nlm.nih.gov·
DIFFERENTIAL DOPAMINE FUNCTION IN FIBROMYALGIA
Fibromyalgia patients show an abnormal dopamine response to pain - PubMed
Fibromyalgia patients show an abnormal dopamine response to pain - PubMed
Fibromyalgia is characterized by chronic widespread pain and bodily tenderness and is often accompanied by affective disturbances. Accumulating evidence indicates that fibromyalgia may involve a dysfunction of modulatory systems in the brain. While brain dopamine is best known for its role in pleasu …
·pubmed.ncbi.nlm.nih.gov·
Fibromyalgia patients show an abnormal dopamine response to pain - PubMed
Repetitive transcranial magnetic stimulation in patients with fibromyalgia: A protocol for systematic review and network meta-analysis
Repetitive transcranial magnetic stimulation in patients with fibromyalgia: A protocol for systematic review and network meta-analysis
Transcranial magnetic stimulation effective at relieving fibromyalgia pain.
Repetitive transcranial magnetic stimulation (rTMS) effectively relieves pain intensity in patients with fibromyalgia. The frequency and target site of rTMS have significant roles in therapy effectiveness.
·ncbi.nlm.nih.gov·
Repetitive transcranial magnetic stimulation in patients with fibromyalgia: A protocol for systematic review and network meta-analysis
Isometric exercise has opposite effects on central pain mechanisms in fibromyalgia patients compared to normal controls - PubMed
Isometric exercise has opposite effects on central pain mechanisms in fibromyalgia patients compared to normal controls - PubMed

Aerobic exercise increases fibromyalgia pain. Isometric exercise improved it.

In contrast, fibromyalgia (FM) subjects' experimental pain ratings increase after aerobic exercise, suggestive of abnormal pain modulation.
·pubmed.ncbi.nlm.nih.gov·
Isometric exercise has opposite effects on central pain mechanisms in fibromyalgia patients compared to normal controls - PubMed
Infrared Radiation in the Management of Musculoskeletal Conditions and Chronic Pain: A Systematic Review
Infrared Radiation in the Management of Musculoskeletal Conditions and Chronic Pain: A Systematic Review

Specifically WA-ON, ceramic-coated

3.1.2. Fibromyalgia Three Randomized controlled trials and one observational study focused on fibromyalgia (FM). These studies were published between 2007 and 2019 and included 219 patients. All studies reported significant pain and FM symptoms reduction and quality of life improvement. In particular, fabrics coated with bioceramics could decrease FM-associated pain and burden in female patients by 21% in the VAS and FIQ assessment scales [17]. WAON therapy (soothing warmth therapy) was associated with an even greater improvement of FM symptoms assessed by both scales (52.7% in VAS, 34.6% in FIQ) in both male and female patients [16]. Similar results were reported with the use of AE and FIR [16] and mild water-filtered near-infrared whole-body hyperthermia (NI-WBH) [15] in both male and female patients. The latter appeared as a beneficial addition to standard multimodal rehabilitation (MR) sessions [15]. FIR treatment sessions were provided for 2–6 weeks [16,18], and patients were monitored for a time period ranging between 2 weeks and 6 months [15]. The reported relief was maintained during the monitoring period [18] or was significant within the first 6 weeks post-treatment [15].
·ncbi.nlm.nih.gov·
Infrared Radiation in the Management of Musculoskeletal Conditions and Chronic Pain: A Systematic Review
Neuroinflammation Microstructural Evidence: Psychological Symptoms & Pain in Fibromyalgia
Neuroinflammation Microstructural Evidence: Psychological Symptoms & Pain in Fibromyalgia
Get to know about the associated changes in neuroinflammation and brain microstructures of patients with fibromyalgia (FM).
microstructural abnormalities associated with neuroinflammation in specific brain areas
indicators for neuron damage
changes in brain microstructures and neuroinflammation in FM patients
·physiciansweekly.com·
Neuroinflammation Microstructural Evidence: Psychological Symptoms & Pain in Fibromyalgia
Structural and functional brain changes in fibromyalgia: investigation of potential mechanisms associated with central sensitization in chronic pain
Structural and functional brain changes in fibromyalgia: investigation of potential mechanisms associated with central sensitization in chronic pain
Despite different techniques, equipment, and statistical criteria, neuroimaging studies have been considerably consistent in the identification of brain regions involved in various pain related processes. Functional neuroimaging studies regularly identify activation differences in a stable set of brain regions between pain and control populations. Recent structural studies have reported similar gray matter abnormalities among multiple chronic pain populations. Yet, the findings from structural and functional imaging studies are not completely unified.
Together, these structural and functional imaging results suggest a functional plasticity of the brain circuitry that is consistent with theories of central sensitization, and may be a key factor in the development and/or maintenance of chronic pain.
·jpain.org·
Structural and functional brain changes in fibromyalgia: investigation of potential mechanisms associated with central sensitization in chronic pain
Low Energy Production and Pain in Fibromyalgia - Is Your Microcirculation To Blame? - Health Rising
Low Energy Production and Pain in Fibromyalgia - Is Your Microcirculation To Blame? - Health Rising
Exercise is highly recommended as an adjunct therapy in fibromyalgia. We’re not talking about pounding the pavement, however. A 2010 review of exercise studies found that ‘slight to moderate’ intensity aerobic exercise sessions done two to three times a week worked best, and that appropriate levels of exercise result in improved […]
At least as early as 2006, researchers suggested that muscle ischemia (low blood flows) both during and after exercise could be causing pain in FM and driving the central sensitization found
Indeed, some research suggests the normal muscle recruitment is not occurring in FM
Problems with the microcirculation could, therefore, be contributing to the aerobic energy problems, pain, and weakness found in FM.
·healthrising.org·
Low Energy Production and Pain in Fibromyalgia - Is Your Microcirculation To Blame? - Health Rising
The widespread myofascial pain of fibromyalgia is sympathetically maintained and immune mediated
Norepinephrine-evoked pain in fibromyalgia. A randomized pilot study [ISRCTN70707830]
Norepinephrine-evoked pain in fibromyalgia. A randomized pilot study [ISRCTN70707830]
Norepinephrine-evoked pain was seen in 80 % of FM patients (95% confidence intervals 56.3 – 94.3%), in 30 % of rheumatoid arthritis patients and in 30 % of healthy controls (95% confidence intervals 11.9 – 54.3) (p < 0.05). Intensity of norepinephrine-evoked pain was greater in FM patients (mean ± SD 2.5 ± 2.5) when compared to rheumatoid arthritis patients (0.3 ± 0.7), and healthy controls (0.3 ± 0.8) p < 0.0001.
·ncbi.nlm.nih.gov·
Norepinephrine-evoked pain in fibromyalgia. A randomized pilot study [ISRCTN70707830]