MCP-1 is increased in patients with CFS and FM, whilst several other immune markers are significantly lower than healthy controls
The role of the immune system in fibromyalgia
What your doctor DOESN'T know about fibromyalgia pain is hurting you!
Immune system, sympathetic nervous system and myofascial abnormalities
MAO-A Inhibition by Metaxalone Reverts IL-1β-Induced Inflammatory Phenotype in Microglial Cells
Interesting that Metaxalone has this effect, and it works well for fibromyalgia. More suggestion that there is an autoimmune component.
Hormonal Health and Wellness Inflammation & Low Dose Naltrexone in Cross Roads, TX | Cross Roads Hormonal Health & Wellness
Low Dose Naltrexone helping fibromyalgial pain.
Evidence of both systemic inflammation and neuroinflammation in fibromyalgia patients, as assessed by a multiplex protein panel applied to the cerebrospinal fluid and to plasma - PubMed
Yes; and evidence can be found in cerebrospinal fluid, so we know there is neuroinflammation in fibromyalgia.
Modafinil goes well beyond addressing fatigue.
I take Nuvigil (armodafinil) which is an isomer of Provigil (modafinil), which was shown to reduce neuroinflammation. Nuvigil takes away a lot of my pain.