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Accelerated Brain Gray Matter Loss in Fibromyalgia Patients: Premature Aging of the Brain?
Accelerated Brain Gray Matter Loss in Fibromyalgia Patients: Premature Aging of the Brain?
Fibromyalgia is an intractable widespread pain disorder that is most frequently diagnosed in women. It has traditionally been classified as either a musculoskeletal disease or a psychological disorder. Accumulating evidence now suggests that fibromyalgia may be associated with CNS dysfunction. In this study, we investigate anatomical changes in the brain associated with fibromyalgia. Using voxel-based morphometric analysis of magnetic resonance brain images, we examined the brains of 10 female fibromyalgia patients and 10 healthy controls. We found that fibromyalgia patients had significantly less total gray matter volume and showed a 3.3 times greater age-associated decrease in gray matter than healthy controls. The longer the individuals had had fibromyalgia, the greater the gray matter loss, with each year of fibromyalgia being equivalent to 9.5 times the loss in normal aging. In addition, fibromyalgia patients demonstrated significantly less gray matter density than healthy controls in several brain regions, including the cingulate, insular and medial frontal cortices, and parahippocampal gyri. The neuroanatomical changes that we see in fibromyalgia patients contribute additional evidence of CNS involvement in fibromyalgia. In particular, fibromyalgia appears to be associated with an acceleration of age-related changes in the very substance of the brain. Moreover, the regions in which we demonstrate objective changes may be functionally linked to core features of the disorder including affective disturbances and chronic widespread pain.
·jneurosci.org·
Accelerated Brain Gray Matter Loss in Fibromyalgia Patients: Premature Aging of the Brain?
Fibromyalgia is characterized by altered frontal and cerebellar structural covariance brain networks - PubMed
Fibromyalgia is characterized by altered frontal and cerebellar structural covariance brain networks - PubMed
Altered brain morphometry has been widely acknowledged in chronic pain, and recent studies have implicated altered network dynamics, as opposed to properties of individual brain regions, in supporting persistent pain. Structural covariance analysis determines the inter-regional association in morpho …
spectral partitioning identified a distinct submodule with cerebellar connections to medial prefrontal and temporal and right inferior parietal lobes, whose gray matter volume was associated with the severity of depression in these patients.
·pubmed.ncbi.nlm.nih.gov·
Fibromyalgia is characterized by altered frontal and cerebellar structural covariance brain networks - PubMed
Fibromyalgia impact in the prefrontal cortex subfields: An assessment with MRI
Fibromyalgia impact in the prefrontal cortex subfields: An assessment with MRI

Women with fibromyalgia showed reduced volume in different subfields of the prefrontal cortex and total gray matter compared to healthy women.

• Various subfields of the prefrontal cortex showed significantly volumetric decreases related to variables such as age and depression.

• The total gray matter shows a significant decrease related to age observed through the analysis of multiple linear regressions.

Women with fibromyalgia showed reduced volume in different subfields of the prefrontal cortex and total gray matter compared to healthy women.•Various subfields of the prefrontal cortex showed significantly volumetric decreases related to variables such as age and depression.•The total gray matter shows a significant decrease related to age observed through the analysis of multiple linear regressions.
·sciencedirect.com·
Fibromyalgia impact in the prefrontal cortex subfields: An assessment with MRI
Accelerated Brain Gray Matter Loss in Fibromyalgia Patients: Premature Aging of the Brain?
Accelerated Brain Gray Matter Loss in Fibromyalgia Patients: Premature Aging of the Brain?
Fibromyalgia is an intractable widespread pain disorder that is most frequently diagnosed in women. It has traditionally been classified as either a musculoskeletal disease or a psychological disorder. Accumulating evidence now suggests that fibromyalgia ...
·ncbi.nlm.nih.gov·
Accelerated Brain Gray Matter Loss in Fibromyalgia Patients: Premature Aging of the Brain?