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Modafinil Reduces Neuronal Pyroptosis and Cognitive Decline After Sleep Deprivation
Modafinil Reduces Neuronal Pyroptosis and Cognitive Decline After Sleep Deprivation
Sleep deprivation (SD) induces systemic inflammation that promotes neuronal pyroptosis. The purpose of this study was to investigate the effect of an antioxidant modafinil on neuronal pyroptosis and cognitive decline following SD. Using a mouse model ...
reduced proinflammatory factor (IL-1β, TNF-α, and IL-6) production, and increased the expression of anti-inflammatory factors (IL-10).
This probably speaks to its role in combating pain in FMS.
Modafinil treatment attenuated inflammasome activity and reduced neuronal pyroptosis involving the NLRP3/NLRP1/NLRC4-caspase-1-IL-1β pathway
IL-1β
IL-6
TNF-α
#research#modafinil#neuroinflammation#brain#inflammation#fibromyalgia#study
·ncbi.nlm.nih.gov·
Modafinil Reduces Neuronal Pyroptosis and Cognitive Decline After Sleep Deprivation
Modulating the immune response with the wake-promoting drug modafinil: A potential therapeutic approach for inflammatory disorders - PubMed
Modulating the immune response with the wake-promoting drug modafinil: A potential therapeutic approach for inflammatory disorders - PubMed
This would explain why the isomer of modafinil that I take, armodafinil, greatly reduces my pain
#immune#immunomodulation#autoimmune#modafinil#neuroinflammation#dopamine#norepinephrine#fibromyalgia#brain#CNS#GABA#pain#research#treatment#rehabilitation
·pubmed.ncbi.nlm.nih.gov·
Modulating the immune response with the wake-promoting drug modafinil: A potential therapeutic approach for inflammatory disorders - PubMed
Caffeine and Modafinil Ameliorate the Neuroinflammation and Anxious Behavior in Rats during Sleep Deprivation by Inhibiting the Microglia Activation
Caffeine and Modafinil Ameliorate the Neuroinflammation and Anxious Behavior in Rats during Sleep Deprivation by Inhibiting the Microglia Activation
Neuroinflammation being a factor, plus modafinil use. In my case, armodafinil works well for pain (Nuvigil).
#caffeine#fibromyalgia#modafinil#neuroinflammation#dopamine#norepinephrine#GABA#brain#autoimmune#immune#immunomodulation#research#treatment#rehabilitation
·frontiersin.org·
Caffeine and Modafinil Ameliorate the Neuroinflammation and Anxious Behavior in Rats during Sleep Deprivation by Inhibiting the Microglia Activation