The widespread myofascial pain of fibromyalgia is sympathetically maintained and immune mediated
Summary of what might really be causing fibromyalgia?
Abnormal neuroinflammation in fibromyalgia and CRPS using [11C]-(R)-PK11195 PET
Abnormal neuroinflammation in fibromyalgia
Prednisone helping fibromyalgia pain
In my case, personally speaking, prednisone gets rid of the pain.
What if pain in fibromyalgia is primarily due to increased muscle tension?
Muscles in fibromyalgia are almost three times more tense.
What your doctor DOESN'T know about fibromyalgia pain is hurting you!
Immune system, sympathetic nervous system and myofascial abnormalities
Passive transfer of fibromyalgia symptoms from patients to mice - PubMed
We can “give” fibromyalgia to mice by transferring fibromyalgia patients’ antibodies to them. Symptoms resolve when antibodies are taken away. Strongly suggests fibromyalgia has an autoimmune component.
![Norepinephrine-evoked pain in fibromyalgia. A randomized pilot study [ISRCTN70707830]](https://rdl.ink/render/https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fcorehtml%2Fpmc%2Fpmcgifs%2Fpmc-card-share.jpg%3F_%3D0?width=92&height=&ar=&mode=&format=avif&dpr=2)
Norepinephrine-evoked pain in fibromyalgia. A randomized pilot study [ISRCTN70707830]
Norepinephrine-evoked pain was seen in 80 % of FM patients (95% confidence intervals 56.3 – 94.3%), in 30 % of rheumatoid arthritis patients and in 30 % of healthy controls (95% confidence intervals 11.9 – 54.3) (p < 0.05). Intensity of norepinephrine-evoked pain was greater in FM patients (mean ± SD 2.5 ± 2.5) when compared to rheumatoid arthritis patients (0.3 ± 0.7), and healthy controls (0.3 ± 0.8) p < 0.0001.
Low-dose naltrexone for the treatment of fibromyalgia: protocol for a double-blind, randomized, placebo-controlled trial
To me, it says probable autoimmune component in fibromyalgia ; LDN is taken by people with autoimmune diseases, and fibromyalgia patients have success with it
The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain
Fibromyalgia patients are having success with it; LDN has an immunomodulatory effect, and to me this also bolsters the case for an autoimmune component in fibromyalgia.
Modulating the immune response with the wake-promoting drug modafinil: A potential therapeutic approach for inflammatory disorders - PubMed
This would explain why the isomer of modafinil that I take, armodafinil, greatly reduces my pain
Evidence of Mitochondrial Dysfunction in Fibromyalgia: Deviating Muscle Energy Metabolism Detected Using Microdialysis and Magnetic Resonance
Mitochondrial dysfunction involvement in fibromyalgia