The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain - PMC
LDN has an anti-inflammatory effect on fibromyalgia ; fibromyalgia has an inflammatory component.
MCP-1 is increased in patients with CFS and FM, whilst several other immune markers are significantly lower than healthy controls
The role of the immune system in fibromyalgia
Fibromyalgia and non-celiac gluten sensitivity: a description with remission of fibromyalgia - PubMed
The aim of this report was to describe 20 selected patients with FM without CD who improved when placed on a gluten-free diet.
Reduced Insular γ-Aminobutyric Acid in Fibromyalgia
GABA deficiency may play a critical role in the pathophysiology of FM.
GABA may play a critical role in the pathophysiology of FM
Palmitoylethanolamide in Fibromyalgia: Results from Prospective and Retrospective Observational Studies
Supplementing with palmitoylethanolamide (PEA) further reduced pain when added to pregabalin and duloxetine.
Targeted Treatment of Age-Related Fibromyalgia with Supplemental Coenzyme Q10 - PubMed
We are deficient in CoQ10
The widespread myofascial pain of fibromyalgia is sympathetically maintained and immune mediated
Summary of what might really be causing fibromyalgia?
Mitochondrial Imbalance as a New Approach to the Study of Fibromyalgia - PubMed
CoQ10 treatment and mitochondrial status
Decreased muscle concentrations of ATP and PCR in the quadriceps muscle of fibromyalgia patients--a 31P-MRS study - PubMed
Alterations in intramuscular ATP, PCr and fat content in FMS probably reflect a combination of inactivity related to pain and dysfunction of muscle mitochondria.
Carnitine Palmitoyl Transferase Deficiency in a University Immunology Practice - PubMed
Many participants had fibromyalgia in this study, and had fatigue and exercise intolerance. Study points to underlying metabolic disease.
Brain glial activation in fibromyalgia - A multi-site positron emission tomography investigation - PubMed
Neuroinflammation from brain glial activation in fibromyalgia
Research shows fibromyalgia is likely a condition of the immune system
New research has shown that many fibromyalgia symptoms are caused by antibodies that increase the activity of pain-sensing nerves throughout the body.
Nerve damage and fibromyalgia — Harvard Gazette
About half of a small group of patients with fibromyalgia — a common syndrome that causes chronic pain and other symptoms — were found to have damage to nerve fibers in their skin and other evidence of a disease called small-fiber polyneuropathy.
What if pain in fibromyalgia is primarily due to increased muscle tension?
Muscles in fibromyalgia are almost three times more tense.
What your doctor DOESN'T know about fibromyalgia pain is hurting you!
Immune system, sympathetic nervous system and myofascial abnormalities
Passive transfer of fibromyalgia symptoms from patients to mice - PubMed
We can “give” fibromyalgia to mice by transferring fibromyalgia patients’ antibodies to them. Symptoms resolve when antibodies are taken away. Strongly suggests fibromyalgia has an autoimmune component.
MAO-A Inhibition by Metaxalone Reverts IL-1β-Induced Inflammatory Phenotype in Microglial Cells
Interesting that Metaxalone has this effect, and it works well for fibromyalgia. More suggestion that there is an autoimmune component.
Metformin and caloric restriction induce an AMPK-dependent restoration of mitochondrial dysfunction in fibroblasts from Fibromyalgia patients
Suggests metabolic syndrome involvement and mitochondrial dysfunction in fibromyalgia development
Brain glial activation in fibromyalgia – A multi-site positron emission tomography investigation
More evidence suggesting autoimmune component in fibromyalgia
Evidence of both systemic inflammation and neuroinflammation in fibromyalgia patients, as assessed by a multiplex protein panel applied to the cerebrospinal fluid and to plasma - PubMed
Yes; and evidence can be found in cerebrospinal fluid, so we know there is neuroinflammation in fibromyalgia.
Norepinephrine-evoked pain in fibromyalgia. A randomized pilot study [ISRCTN70707830]
Norepinephrine-evoked pain was seen in 80 % of FM patients (95% confidence intervals 56.3 – 94.3%), in 30 % of rheumatoid arthritis patients and in 30 % of healthy controls (95% confidence intervals 11.9 – 54.3) (p < 0.05). Intensity of norepinephrine-evoked pain was greater in FM patients (mean ± SD 2.5 ± 2.5) when compared to rheumatoid arthritis patients (0.3 ± 0.7), and healthy controls (0.3 ± 0.8) p < 0.0001.
Central Role of Dopamine in Fibromyalgia
A review of the evidence that fibromyalgia is associated with a disruption of dopaminergic neurotransmission together with a discussion of its therapeutic implications.
Low-dose naltrexone for the treatment of fibromyalgia: protocol for a double-blind, randomized, placebo-controlled trial
To me, it says probable autoimmune component in fibromyalgia ; LDN is taken by people with autoimmune diseases, and fibromyalgia patients have success with it
Cetirizine and allopurinol as novel weapons against cellular autoimmune disorders - PubMed
Some people with autoimmune diseases take cetirizine
The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain
Fibromyalgia patients are having success with it; LDN has an immunomodulatory effect, and to me this also bolsters the case for an autoimmune component in fibromyalgia.
Modulating the immune response with the wake-promoting drug modafinil: A potential therapeutic approach for inflammatory disorders - PubMed
This would explain why the isomer of modafinil that I take, armodafinil, greatly reduces my pain
Caffeine and Modafinil Ameliorate the Neuroinflammation and Anxious Behavior in Rats during Sleep Deprivation by Inhibiting the Microglia Activation
Neuroinflammation being a factor, plus modafinil use. In my case, armodafinil works well for pain (Nuvigil).
Metformin and caloric restriction induce an AMPK-dependent restoration of mitochondrial dysfunction in fibroblasts from Fibromyalgia patients
Some suggest insulin resistance as a cause of fibromyalgia
Metformin and caloric restriction induce an AMPK-dependent restoration of mitochondrial dysfunction in fibroblasts from Fibromyalgia patients
Immunometabolic modulatory role of naltrexone in micro glial cells
Suggests fibromyalgia has An autoimmune component
Evidence of Mitochondrial Dysfunction in Fibromyalgia: Deviating Muscle Energy Metabolism Detected Using Microdialysis and Magnetic Resonance
Mitochondrial dysfunction involvement in fibromyalgia