Fibromyalgia (FM) is a disorder characterized by chronic diffuse pain and enhanced pain response to stimuli and is caused by central sensitization Tinnitus also is related to central sensitization So we investigated the impact of tinnitus on FMWe included ...
The FM patients with severe tinnitus had more functional impairments and lower quality of life than those with mild tinnitus Severe insomnia also was accompanied by worse health status and lower quality of life
Mitochondrial Enhancers for ME/CFS and Fibromyalgia Pt IV: N-Acetyl Cysteine (NAC) - Health Rising
This is bookmarked because FMS symptoms like mitochondrial dysfunction and ischemia overlap with those of ME/CFS. Interesting choice of supplement suggestions backed with research.
N-acetyl cysteine or NAC is a most interesting compound. Most often thought of as an antioxidant it appears to be able to enhance mitochondrial production as well.
Perhaps the most powerful antioxidant available and certainly the most widely studied, NAC is able to rejuvenate the levels of glutathione – the most powerful antioxidant in the body. It appears to do its work mostly in the mitochondria where recent research indicates it also triggers the production of hydrogen sulfide which, in turn, produces antioxidant effects and perhaps enhances ATP production as well.
A 2019 hypothesis paper proposed that supplements like coenzyme Q10, melatonin, curcumin, molecular hydrogen, and N-acetylcysteine could be helpful in ME/CFS patients with inflammation, increased oxidative and nitrosative stress, leaky gut, and mitochondrial dysfunction.
Shungu, interestingly, does not believe ME/CFS is a mitochondrial disorder. The mitochondria are affected in ME/CFS but at its heart, Shungu believes ME/CFS is an oxidative stress-induced micro-circulatory disease. High levels of oxidative stress are causing the blood vessels to shut down, making it impossible for the oxygen the mitochondria need to get through. Shungu’s hypothesis, which was produced some time ago, is circling around the same blood flow issues that other hypotheses are.
Luteolin: A promising natural agent in management of pain in chronic conditions
Pain due to chronic conditions is a frequent and insufficiently addressed problem. Current drug options for pain management (either in cases of chronic inflammatory conditions or neuropathy) do not adequately treat pain. Moreover, they are associated ...
The data reviewed strongly support luteolin's promising benefits in pain management and raise the need for further clinical trials that can establish its role in clinical practice.
Pregabalin and gabapentin reduce release of substance P and CGRP from rat spinal tissues only after inflammation or activation of protein kinase C - PubMed
Pregabalin = An immunomodulator, then? Substance P stimulates immune cells to release things.
Our results suggest that gabapentin and pregabalin modulate the release of sensory neuropeptides, but only under conditions corresponding to significant inflammation-induced sensitization of the spinal cord.
It’s worth hearing him out; he cites studies, and he is not the only one with this theory. SIBO and fibromyalgia are strongly correlated, and as he shows, it is more likely that SIBO could cause [some cases of] fibromyalgia and not the other way around.
Accelerated Brain Gray Matter Loss in Fibromyalgia Patients: Premature Aging of the Brain?
Fibromyalgia is an intractable widespread pain disorder that is most frequently diagnosed in women. It has traditionally been classified as either a musculoskeletal disease or a psychological disorder. Accumulating evidence now suggests that fibromyalgia may be associated with CNS dysfunction. In this study, we investigate anatomical changes in the brain associated with fibromyalgia. Using voxel-based morphometric analysis of magnetic resonance brain images, we examined the brains of 10 female fibromyalgia patients and 10 healthy controls. We found that fibromyalgia patients had significantly less total gray matter volume and showed a 3.3 times greater age-associated decrease in gray matter than healthy controls. The longer the individuals had had fibromyalgia, the greater the gray matter loss, with each year of fibromyalgia being equivalent to 9.5 times the loss in normal aging. In addition, fibromyalgia patients demonstrated significantly less gray matter density than healthy controls in several brain regions, including the cingulate, insular and medial frontal cortices, and parahippocampal gyri. The neuroanatomical changes that we see in fibromyalgia patients contribute additional evidence of CNS involvement in fibromyalgia. In particular, fibromyalgia appears to be associated with an acceleration of age-related changes in the very substance of the brain. Moreover, the regions in which we demonstrate objective changes may be functionally linked to core features of the disorder including affective disturbances and chronic widespread pain.
Fibromyalgia is characterized by altered frontal and cerebellar structural covariance brain networks - PubMed
Altered brain morphometry has been widely acknowledged in chronic pain, and recent studies have implicated altered network dynamics, as opposed to properties of individual brain regions, in supporting persistent pain. Structural covariance analysis determines the inter-regional association in morpho …
spectral partitioning identified a distinct submodule with cerebellar connections to medial prefrontal and temporal and right inferior parietal lobes, whose gray matter volume was associated with the severity of depression in these patients.
Fibromyalgia impact in the prefrontal cortex subfields: An assessment with MRI
Women with fibromyalgia showed reduced volume in different subfields of the prefrontal cortex and total gray matter compared to healthy women.
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Various subfields of the prefrontal cortex showed significantly volumetric decreases related to variables such as age and depression.
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The total gray matter shows a significant decrease related to age observed through the analysis of multiple linear regressions.
Women with fibromyalgia showed reduced volume in different subfields of the prefrontal cortex and total gray matter compared to healthy women.•Various subfields of the prefrontal cortex showed significantly volumetric decreases related to variables such as age and depression.•The total gray matter shows a significant decrease related to age observed through the analysis of multiple linear regressions.
The Link between Fibromyalgia Syndrome and Anger: A Systematic Review Revealing Research Gaps
Anger has been associated with increased pain perception, but its specific connection with Fibromyalgia Syndrome (FMS) has not yet been established in an integrated approach. Therefore, the present systematic review focuses on exploring this connection, ...
Effect of Steroids on Patients With Fibromyalgia/Chromic Widespread Pain: An Observational Study
Objective: Fibromyalgia causes widespread chronic pain. Pain management and treating underlying conditions are of utmost importance. Recent studies found an association of thyroid autoimmunity with fibromyalgia. Pain management of patients with anti-thyroid ...
We found that 51.6% of the patients responded well to the steroid therapy
Anti-satellite glia cell IgG antibodies in fibromyalgia patients are related to symptom severity and to metabolite concentrations in thalamus and rostral anterior cingulate cortex
Recent translational work has shown that fibromyalgia might be an autoimmune condition with pathogenic mechanisms mediated by a peripheral, pain-induc…
Repeated cold stress, an animal model for fibromyalgia, elicits proprioceptor-induced chronic pain with microglial activation in mice - Journal of Neuroinflammation
Background Fibromyalgia is characterized by chronic pain, fatigue, and other somatic symptoms. We have recently revealed that proprioceptor hyperactivation induces chronic pain in a rat model of myalgic encephalomyelitis. The present study explores whether similar proprioceptor-induced pain is elicited in a mouse model of fibromyalgia. Methods Repeated cold stress (RCS) was used as a fibromyalgia model. Pain behavior was examined using the von Frey test, and neuronal activation was examined immunohistochemically as activating transcription factor (ATF)3 expression. The Atf3:BAC transgenic mouse, in which mitochondria in hyperactivated neurons are specifically labeled by green fluorescent protein, was used to trace the activated neuronal circuit. PLX3397 (pexidartinib) was used for microglial suppression. Results RCS elicited long-lasting pain in mice. ATF3, a marker of cellular hyperactivity and injury, was expressed in the lumbar dorsal root ganglion (DRG) 2 days after RCS initiation; the majority of ATF3-expressing DRG neurons were tropomyosin receptor kinase C- and/or vesicular glutamate transporter 1-positive proprioceptors. Microglial activation and increased numbers of microglia were observed in the medial part of the nucleus proprius 5 days after RCS initiation, and in the dorsal region of the ventral horn 7 days after RCS. In the ventral horn, only a subset of motor neurons was positive for ATF3; these neurons were surrounded by activated microglia. A retrograde tracer study revealed that ATF3-positive motor neurons projected to the intrinsic muscles of the foot (IMF). Using Atf3:BAC transgenic mice, we traced hyperactivated neuronal circuits along the reflex arc. Green fluorescent protein labeling was observed in proprioceptive DRG neurons and their processes originating from the IMF, as well as in motor neurons projecting to the IMF. Microglial activation was observed along this reflex arc, and PLX3397-induced microglial ablation significantly suppressed pain behavior. Conclusion Proprioceptor hyperactivation leads to local microglial activation along the reflex arc; this prolonged microglial activation may be responsible for chronic pain in the present model. Proprioceptor-induced microglial activation might be the common cause of chronic pain in both the fibromyalgia and myalgic encephalomyelitis models, although the experimental models are different.
Neutrophils infiltrate sensory ganglia and mediate chronic widespread pain in fibromyalgia | PNAS
Conclusion: “We used a model of hyperalgesic priming to induce chronic widespread pain in mice that resulted in robust and persistent ipsilateral and contralateral behavioral hypersensitivity and sensitization of spinal cord neurons. Adoptive transfer of neutrophils from primed mice and from patients with fibromyalgia syndrome confers mechanical pain to recipient naïve mice, sensitizes evoked action potential firing of spinal cord neurons, and causes neutrophil infiltration into the dorsal root ganglia. These data demonstrate that neutrophils are fundamental for the development of chronic widespread pain through infiltration of peripheral sensory ganglia. Further studies characterizing the neutrophil phenotype in fibromyalgia syndrome may shed light on mediators of the cross talk between these polymorphonuclear granulocytes and sensory neurons. Our findings suggest that targeting neutrophils may be useful therapeutic targets for pain control in fibromyalgia.”
Unbiased immune profiling reveals a natural killer cell-peripheral nerve axis in fibromyalgia
Conclusion: “This study identified a neuro-immune interface between peripheral nerves and NK cells in FMS patients that suggests a novel mechanism for FMS pathogenesis and a new direction in the development of therapeutic options to treat this poorly managed syndrome.”
Approximately 30% of Americans suffer from chronic pain disorders, such as fibromyalgia (FM), which can cause debilitating pain. Many pain-killing drugs prescribed for chronic pain disorders are highly addictive, have limited clinical efficacy, and do ...
Fibromyalgia patients show an abnormal dopamine response to pain - PubMed
Fibromyalgia is characterized by chronic widespread pain and bodily tenderness and is often accompanied by affective disturbances. Accumulating evidence indicates that fibromyalgia may involve a dysfunction of modulatory systems in the brain. While brain dopamine is best known for its role in pleasu …
Altered dopamine D2 receptor function in fibromyalgia patients: a neuroendocrine study with buspirone in women with fibromyalgia compared to female population based controls
Altered Functional Performance in Patients with Fibromyalgia
Conclusion: Our data revealed that both gait and balance were severely impaired in FM, and that subjective complaints associated with FM could contribute to functional disability in these patients. These findings suggest that optimal rehabilitation and fall prevention in fibromyalgia require a comprehensive assessment of both psychological responses to pain and physical impairments during postural control and gait.
Conclusion: Our data revealed that both gait and balance were severely impaired in FM, and that subjective complaints associated with FM could contribute to functional disability in these patients. These findings suggest that optimal rehabilitation and fall prevention in fibromyalgia require a comprehensive assessment of both psychological responses to pain and physical impairments during postural control and gait.
[Adrenal crisis associated with modafinil use] - PubMed
Wondering if my adrenal insufficiency is due to Armodafinil use. Armodafinil helps my fibromyalgia pain, but adrenal insufficiency in fibromyalgia is common.
Modulatory Effects of Modafinil on Neural Circuits Regulating Emotion and Cognition
The calming of the amygdala with low-dose modafinil (100 mg) might have something to do with the way it hinders neuroinflammation and therefore fibromyalgia pain, is my guess. Armodafinil helps me; modafinil helps another Redditor.
Repetitive transcranial magnetic stimulation in patients with fibromyalgia: A protocol for systematic review and network meta-analysis
Transcranial magnetic stimulation effective at relieving fibromyalgia pain.
Repetitive transcranial magnetic stimulation (rTMS) effectively relieves pain intensity in patients with fibromyalgia. The frequency and target site of rTMS have significant roles in therapy effectiveness.
Oxidative Stress in Fibromyalgia: From Pathology to Treatment
Fibromyalgia (FM) is characterized by chronic widespread musculoskeletal pain associated with sleep problems, fatigue, depression, and anxiety. The persistence of pain, impairment of cognitive function, and negative impact on the psychological state have ...
Infrared Radiation in the Management of Musculoskeletal Conditions and Chronic Pain: A Systematic Review
Specifically WA-ON, ceramic-coated
3.1.2. Fibromyalgia Three Randomized controlled trials and one observational study focused on fibromyalgia (FM). These studies were published between 2007 and 2019 and included 219 patients. All studies reported significant pain and FM symptoms reduction and quality of life improvement. In particular, fabrics coated with bioceramics could decrease FM-associated pain and burden in female patients by 21% in the VAS and FIQ assessment scales [17]. WAON therapy (soothing warmth therapy) was associated with an even greater improvement of FM symptoms assessed by both scales (52.7% in VAS, 34.6% in FIQ) in both male and female patients [16]. Similar results were reported with the use of AE and FIR [16] and mild water-filtered near-infrared whole-body hyperthermia (NI-WBH) [15] in both male and female patients. The latter appeared as a beneficial addition to standard multimodal rehabilitation (MR) sessions [15]. FIR treatment sessions were provided for 2–6 weeks [16,18], and patients were monitored for a time period ranging between 2 weeks and 6 months [15]. The reported relief was maintained during the monitoring period [18] or was significant within the first 6 weeks post-treatment [15].
Is fibromyalgia associated with a unique cytokine profile? A systematic review and meta-analysis
We found evidence of significant differences in the peripheral blood cytokine profiles of fibromyalgia patients compared with HC. However, the distinctive profile associated with fibromyalgia includes both pro-inflammatory (TNF-α, IL-6, IL-8) and anti-inflammatory (IL-10) cytokines in pooled analysis, as well as chemokine (eotaxin) signatures. Further research is required to elucidate the role of cytokines in fibromyalgia.
We found evidence of significant differences in the peripheral blood cytokine profiles of fibromyalgia patients compared with HC. However, the distinctive profile associated with fibromyalgia includes both pro-inflammatory (TNF-α, IL-6, IL-8) and anti-inflammatory (IL-10) cytokines in pooled analysis, as well as chemokine (eotaxin) signatures. Further research is required to elucidate the role of cytokines in fibromyalgia.
Neuropeptides CRH, SP, HK-1, and Inflammatory Cytokines IL-6 and TNF Are Increased in Serum of Patients with Fibromyalgia Syndrome, Implicating Mast Cells
