Reduced Insular γ-Aminobutyric Acid in Fibromyalgia
GABA deficiency may play a critical role in the pathophysiology of FM.
GABA may play a critical role in the pathophysiology of FM
Fibromyalgia
Palmitoylethanolamide in Fibromyalgia: Results from Prospective and Retrospective Observational Studies
Supplementing with palmitoylethanolamide (PEA) further reduced pain when added to pregabalin and duloxetine.
Targeted Treatment of Age-Related Fibromyalgia with Supplemental Coenzyme Q10 - PubMed
We are deficient in CoQ10
The widespread myofascial pain of fibromyalgia is sympathetically maintained and immune mediated
Summary of what might really be causing fibromyalgia?
Abnormal neuroinflammation in fibromyalgia and CRPS using [11C]-(R)-PK11195 PET
Abnormal neuroinflammation in fibromyalgia
Mitochondrial Imbalance as a New Approach to the Study of Fibromyalgia - PubMed
CoQ10 treatment and mitochondrial status
Decreased muscle concentrations of ATP and PCR in the quadriceps muscle of fibromyalgia patients--a 31P-MRS study - PubMed
Alterations in intramuscular ATP, PCr and fat content in FMS probably reflect a combination of inactivity related to pain and dysfunction of muscle mitochondria.
Carnitine Palmitoyl Transferase Deficiency in a University Immunology Practice - PubMed
Many participants had fibromyalgia in this study, and had fatigue and exercise intolerance. Study points to underlying metabolic disease.
Brain glial activation in fibromyalgia - A multi-site positron emission tomography investigation - PubMed
Neuroinflammation from brain glial activation in fibromyalgia
Prednisone helping fibromyalgia pain
In my case, personally speaking, prednisone gets rid of the pain.
Research shows fibromyalgia is likely a condition of the immune system
New research has shown that many fibromyalgia symptoms are caused by antibodies that increase the activity of pain-sensing nerves throughout the body.
Nerve damage and fibromyalgia — Harvard Gazette
About half of a small group of patients with fibromyalgia — a common syndrome that causes chronic pain and other symptoms — were found to have damage to nerve fibers in their skin and other evidence of a disease called small-fiber polyneuropathy.
What if pain in fibromyalgia is primarily due to increased muscle tension?
Muscles in fibromyalgia are almost three times more tense.
Fibromyalgia Cutting Through the B.S.
Dr. Martin Rutherford, M.D. has fibromyalgia, and he discusses his experience and opinions.
What your doctor DOESN'T know about fibromyalgia pain is hurting you!
Immune system, sympathetic nervous system and myofascial abnormalities
Dr. Ginevra | Fibromyalgia
Dr. Ginevra is a leading expert in fibromyalgia. She also has fibromyalgia.
Passive transfer of fibromyalgia symptoms from patients to mice - PubMed
We can “give” fibromyalgia to mice by transferring fibromyalgia patients’ antibodies to them. Symptoms resolve when antibodies are taken away. Strongly suggests fibromyalgia has an autoimmune component.
MAO-A Inhibition by Metaxalone Reverts IL-1β-Induced Inflammatory Phenotype in Microglial Cells
Interesting that Metaxalone has this effect, and it works well for fibromyalgia. More suggestion that there is an autoimmune component.
Metformin and caloric restriction induce an AMPK-dependent restoration of mitochondrial dysfunction in fibroblasts from Fibromyalgia patients
Suggests metabolic syndrome involvement and mitochondrial dysfunction in fibromyalgia development
Hormonal Health and Wellness Inflammation & Low Dose Naltrexone in Cross Roads, TX | Cross Roads Hormonal Health & Wellness
Low Dose Naltrexone helping fibromyalgial pain.
Brain glial activation in fibromyalgia – A multi-site positron emission tomography investigation
More evidence suggesting autoimmune component in fibromyalgia
Evidence of both systemic inflammation and neuroinflammation in fibromyalgia patients, as assessed by a multiplex protein panel applied to the cerebrospinal fluid and to plasma - PubMed
Yes; and evidence can be found in cerebrospinal fluid, so we know there is neuroinflammation in fibromyalgia.
Norepinephrine-evoked pain in fibromyalgia. A randomized pilot study [ISRCTN70707830]
Norepinephrine-evoked pain was seen in 80 % of FM patients (95% confidence intervals 56.3 – 94.3%), in 30 % of rheumatoid arthritis patients and in 30 % of healthy controls (95% confidence intervals 11.9 – 54.3) (p < 0.05). Intensity of norepinephrine-evoked pain was greater in FM patients (mean ± SD 2.5 ± 2.5) when compared to rheumatoid arthritis patients (0.3 ± 0.7), and healthy controls (0.3 ± 0.8) p < 0.0001.
Central Role of Dopamine in Fibromyalgia
A review of the evidence that fibromyalgia is associated with a disruption of dopaminergic neurotransmission together with a discussion of its therapeutic implications.
Low-dose naltrexone for the treatment of fibromyalgia: protocol for a double-blind, randomized, placebo-controlled trial
To me, it says probable autoimmune component in fibromyalgia ; LDN is taken by people with autoimmune diseases, and fibromyalgia patients have success with it
Cetirizine and allopurinol as novel weapons against cellular autoimmune disorders - PubMed
Some people with autoimmune diseases take cetirizine
The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain
Fibromyalgia patients are having success with it; LDN has an immunomodulatory effect, and to me this also bolsters the case for an autoimmune component in fibromyalgia.
Modafinil goes well beyond addressing fatigue.
I take Nuvigil (armodafinil) which is an isomer of Provigil (modafinil), which was shown to reduce neuroinflammation. Nuvigil takes away a lot of my pain.
Modulating the immune response with the wake-promoting drug modafinil: A potential therapeutic approach for inflammatory disorders - PubMed
This would explain why the isomer of modafinil that I take, armodafinil, greatly reduces my pain
Caffeine and Modafinil Ameliorate the Neuroinflammation and Anxious Behavior in Rats during Sleep Deprivation by Inhibiting the Microglia Activation
Neuroinflammation being a factor, plus modafinil use. In my case, armodafinil works well for pain (Nuvigil).