Hadi Rangin is an expert user of screen reader software. In this video, he demonstrates the elements of a well designed web page and how they sound to someone who is blind. Issues discussed include ARIA landmarks, headings, and text content. Also available with audio description: https://youtu.be/5UD4BKAJZnQ

Color isn't omnipotent, it can't solve all of your problems alone. But with a proper base color is able to beautify UI and improve UX.