Neurologic Impacts of Long COVID, an Autoimmune Syndrome: Igor Koralnik, MD
“We believe Long COVID is a new autoimmune syndrome, which occurs when the immune system becomes confused by the virus and begins to attack the body..”
Covid and Autoimmune Disease
Strategic Inhibition of CHRM Autoantibodies: Molecular Insights and Therapeutic Potentials in Long COVID
Long COVID study finds autoantibodies attacking brain receptors disrupt cognition and cause sensory issues.
Targeted therapies like blood filtration show promise for relief.
Sjogren's Syndrome covid - Google Scholar
“Evidence of a Sjögren’s disease–like phenotype following COVID-19 in mice and humans”
Evidence of a Sjögren’s disease–like phenotype following COVID-19 in mice and humans
Increase in the number of Sjögren's syndrome cases in Brazil in the COVID‐19 Era
Covid-19 may raise risk of developing multiple sclerosis
“a large-scale sample of Covid survivors and nonCovid controls, those post Covid had more than double the risk of being diagnosed with MS than those without a Covid-19 diagnosis.”
COVID-19 linked to long-term risk for autoimmune, autoinflammatory disease
“COVID-19 linked to long-term risk for autoimmune, autoinflammatory disease”
COVID-19 linked to long-term risk for autoimmune, autoinflammatory disease
Long-Term Risk of Autoimmune and Autoinflammatory Disorders After COVID-19
Korean study of 6.9M people found COVID-19 increases autoimmune disease risk.
Alopecia Totalis was 24 percent higher.
Behçet Disease 45 percent higher.
Crohn Disease 35 percent higher.
Bullous Pemphigoid 62 percent higher.
POTS and COVID-19: What is the link?
“there may be a link between COVID-19 and postural orthostatic tachycardia syndrome (POTS). One theory explains that the virus may cause the immune system to attack itself.”
there may be a link between COVID-19 and postural orthostatic tachycardia syndrome (POTS). One theory explains that the virus may cause the immune system to attack itself.
Understanding autoimmune response after SARS-CoV-2 infection and the pathogenesis/mechanisms of long COVID
Key finding: Long COVID linked to new autoimmune disorders like lupus, myasthenia gravis.
COVID-19 worsens Autoimmune Diseases! Study reveals 30 percent spike in antinuclear antibody positivity
“new study has revealed shocking details about the long-term health impacts of COVID-19, particularly concerning autoimmune diseases. The study conducted by Metropolis analyzed data from over 1.2 lakh cases, comparing two critical periods—2019 (pre-COVID) and 2022 (post-COVID). The findings revealed a striking 30% increase in the prevalence of Antinuclear Antibody (ANA) positivity in the Indian population, indicating how the immune system may, in some cases, turn against the body’s own tissues following a COVID-19 infection.”
Multi-ancestry GWAS of Long COVID identifies immune-related loci and etiological links to chronic fatigue syndrome, fibromyalgia and depression
“Using consented and genotyped data from 23andMe adult research participants, we conducted the largest multi-ancestry meta-analysis of genome-wide association studies of Long COVID across European (42,899 cases, 94,721 controls), Latinx (8,631 cases, 20,351 controls), and African-American (2,234 cases, 5,596 controls) genetic ancestry groups. GWAS of Long COVID identified three genome-wide significant loci (HLA-DQA1 and HLA-DQB, ABO, BPTF:KPAN2:C17orf58). Functional analysis of these genes points to underlying immune and thrombo-inflammatory mechanisms.”
Using consented and genotyped data from 23andMe adult research participants, we conducted the largest multi-ancestry meta-analysis of genome-wide association studies of Long COVID across European (42,899 cases, 94,721 controls), Latinx (8,631 cases, 20,351 controls), and African-American (2,234 cases, 5,596 controls) genetic ancestry groups. GWAS of Long COVID identified three genome-wide significant loci (HLA-DQA1 and HLA-DQB, ABO, BPTF:KPAN2:C17orf58). Functional analysis of these genes points to underlying immune and thrombo-inflammatory mechanisms.
This is live on 23&Me.
HLA-DRB1 gene and Long Covid
SARS-CoV-2 spike aggravates lupus nephritis and lung fibrosis in systemic lupus erythematosus
South Korea study suggests SarsCov2 accelerates progression of Lupus.
COVID-19 spike protein worsens lupus, increasing autoantibodies, kidney damage, and lung fibrosis.
Patients With Arthritis, IBD, Experience High Rates of Long Covid Affecting QoL
“A significant portion of people with systemic autoimmune disease, including inflammatory arthritis and inflammatory bowel disease, experienced post-acute sequelae of COVID-19 (PASC), which often affected quality of life.”
A significant portion of people with systemic autoimmune disease, including inflammatory arthritis and inflammatory bowel disease, experienced post-acute sequelae of COVID-19 (PASC), which often affected quality of life
Efficacy of Repeat Immunoadsorption in Post-COVID ME/CFS Patients with Elevated Β2-Adrenergic Receptor Autoantibodies: A Prospective Cohort Study
immunoadsorption (removing antibodies from blood) temporarily improves Long COVID symptoms. Strongly underlines the therapeutic potential of targeting autoimmunity:
Father prepares to lay his daughter to rest after COVID-19 complications a month after testing positive
“Amid a rise in COVID-19 cases in Alabama, one father in Arely is preparing to lay his daughter to rest.
Byron Farmer said his daughter Amber tested positive for covid about a month ago, but she just died unexpectedly from complications on Wednesday. After she came down with COVID-19, Byron told WVTM 13 his daughter never fully recovered”
Amid a rise in COVID-19 cases in Alabama, one father in Arely is preparing to lay his daughter to rest.
Byron Farmer said his daughter Amber tested positive for covid about a month ago, but she just died unexpectedly from complications on Wednesday. After she came down with COVID-19, Byron told WVTM 13 his daughter never fully recovered
Mild Primary or Breakthrough SARS-CoV-2 Infection Promotes Autoantibody Production in Individuals with and without Neuro-PASC | ImmunoHorizons | American Association of Immunologists
“In this study, we demonstrate that mild SARS-CoV-2 infection increases autoantibodies associated with rheumatic autoimmune diseases and diabetes in most individuals, regardless of vaccination status prior to infection…
…These data highlight the need for additional strategies to decrease the spread of SARS-CoV-2 such as the development of vaccines that can prevent infection rather than decrease severity of acute disease alone.”
Yes, it’s not mild. I can tell this with my own ordeal.
Yes, it’s not mild. I can tell this with my own ordeal.
I had Covid 3 times: Sept’20 (WT), Jan’ 22 (BA.2) & Feb’24 (JN.1). The last one was the least severe, but it was the one that left an indelible mark on my skin-Psoriasis, a chronic autoimmune ailment!
The intersection of microbiome and autoimmunity in long COVID-19: Current insights and future directions
Research suggests #longcovid linked to autoimmune responses and imbalances in the microbiome.
Probiotics may help reduce symptoms, but more research is needed.
Post-COVID-19 Syndrome Associated With Multiple Autoimmune Diseases (DM I—LADA, Chronic Autoimmune Thyroiditis and Pernicious Anemia): Case Report - Gordana Milic, Masa Ristic, Milica Milosevic, Nikola Mitovic, Ljubica Dimitrijevic, Tanja Jesic Petrovic, Bojana Salovic, 2024
Post-COVID-19 Syndrome Associated With Multiple Autoimmune Diseases (DM I—LADA, Chronic Autoimmune Thyroiditis and Pernicious Anemia): Case Report, 2024
The potential role of SARS-CoV-2 as a trigger for specific autoimmune conditions.
MDA5-autoimmunity and interstitial pneumonitis contemporaneous with the COVID-19 pandemic (MIP-C)
🚨A distinct pattern of Melanoma Differentiation-Associated protein-5-autoimmunity cases surged contemporaneously with circulation of the SARS-COV-2 virus during COVID19. Bioinformatic insights suggest a shared immunopathology with known autoimmune lung disease mechanisms.
Laura Miers on Twitter
Detailed thread on Twitter covering autoimmune encephalitis "We may be entering an era of heightened autoimmune encephalitis. These occurrences may be post-infectious in nature at this point of the pandemic."
A Sharp Rise in Autoimmune Encephalitis in the COVID-19 Era: A Case Series
“Autoimmune encephalitis was very rare prior to the current pandemic. A sharp rise in cases has been observed from March to August of 2022 in Los Angeles.”
Autoimmune encephalitis associated with COVID-19: A systematic review - PubMed
"Our systematic review revealed evidence on AE development in patients infected with the COVID-19. Clinicians should be aware of the possible diagnosis of AE when considering other neurological differential diagnosis in SARS-CoV-2 infected patients."
High risk of autoimmune diseases after COVID-19
Three new studies give us good estimates of a heightened risk of auto-immune disease after COVID-19 infection. Risk increases of between 20 and 40%
This data franks earlier evidence about lots of self-directed antibodies seen in people post-COVID
Correlation of covid-19 and Guillain-Barré syndrome: A Mechanistic Perspective
"SARS-CoV-2 uses angiotensin-converting enzyme 2 as its entry receptor and enters the central nervous system.. the virus can infect peripheral neurons to cause direct damage.. the number of Guillain-Barré Syndrome patients linked to COVID19 has increased significantly."
High risk of autoimmune diseases after COVID-19
"Two studies that use large cohorts now highlight that SARS-CoV-2 infection is linked to a substantially increased risk of developing a diverse spectrum of new-onset autoimmune diseases."
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RISK of AUTOIMMUNE DISEASES in patients with COVID-19: A retrospective cohort study
A Comprehensive Review of COVID-19–Associated Endocrine Manifestations
As result of the COVID-19 infections, "Thyroid dysfunction with subacute thyroiditis, Graves’ disease & hypothyroidism caused by primary autoimmune thyroiditis has been reported. Pancreatic damage leads to type 1 DM because of the autoimmune nature of the disease and type 2 DM because of postinflammatory insulin resistance."
COVID-19 linked to 40% increase in autoimmune disease risk in huge study
"Catching COVID-19 may raise the risk of developing autoimmune disease by 43% in the months following the infection, according to the largest study of its kind."
Evidence of a Sjögren’s disease-like phenotype following COVID-19
"Evidence of a Sjögren’s disease-like phenotype following COVID-19"