Chronic inflammation in Long COVID relationship to autoimmune diseases
Reminder: Long COVID drives autoimmune diseases through chronic inflammation and immune dysregulation.
➡️Many studies have suggested that systemic chronic inflammation caused by residual viral components may be one of the pathophysiologic mechanisms of Long COVID.
➡️In this paper, they reviewed the autoimmune diseases caused by chronic inflammation.
Neurologic Impacts of Long COVID, an Autoimmune Syndrome: Igor Koralnik, MD
“We believe Long COVID is a new autoimmune syndrome, which occurs when the immune system becomes confused by the virus and begins to attack the body..”
Covid-19 may raise risk of developing multiple sclerosis
“a large-scale sample of Covid survivors and nonCovid controls, those post Covid had more than double the risk of being diagnosed with MS than those without a Covid-19 diagnosis.”
“there may be a link between COVID-19 and postural orthostatic tachycardia syndrome (POTS). One theory explains that the virus may cause the immune system to attack itself.”
there may be a link between COVID-19 and postural orthostatic tachycardia syndrome (POTS). One theory explains that the virus may cause the immune system to attack itself.
COVID-19 worsens Autoimmune Diseases! Study reveals 30 percent spike in antinuclear antibody positivity
“new study has revealed shocking details about the long-term health impacts of COVID-19, particularly concerning autoimmune diseases. The study conducted by Metropolis analyzed data from over 1.2 lakh cases, comparing two critical periods—2019 (pre-COVID) and 2022 (post-COVID). The findings revealed a striking 30% increase in the prevalence of Antinuclear Antibody (ANA) positivity in the Indian population, indicating how the immune system may, in some cases, turn against the body’s own tissues following a COVID-19 infection.”
Multi-ancestry GWAS of Long COVID identifies immune-related loci and etiological links to chronic fatigue syndrome, fibromyalgia and depression
“Using consented and genotyped data from 23andMe adult research participants, we conducted the largest multi-ancestry meta-analysis of genome-wide association studies of Long COVID across European (42,899 cases, 94,721 controls), Latinx (8,631 cases, 20,351 controls), and African-American (2,234 cases, 5,596 controls) genetic ancestry groups. GWAS of Long COVID identified three genome-wide significant loci (HLA-DQA1 and HLA-DQB, ABO, BPTF:KPAN2:C17orf58). Functional analysis of these genes points to underlying immune and thrombo-inflammatory mechanisms.”
Using consented and genotyped data from 23andMe adult research participants, we conducted the largest multi-ancestry meta-analysis of genome-wide association studies of Long COVID across European (42,899 cases, 94,721 controls), Latinx (8,631 cases, 20,351 controls), and African-American (2,234 cases, 5,596 controls) genetic ancestry groups. GWAS of Long COVID identified three genome-wide significant loci (HLA-DQA1 and HLA-DQB, ABO, BPTF:KPAN2:C17orf58). Functional analysis of these genes points to underlying immune and thrombo-inflammatory mechanisms.
Patients With Arthritis, IBD, Experience High Rates of Long Covid Affecting QoL
“A significant portion of people with systemic autoimmune disease, including inflammatory arthritis and inflammatory bowel disease, experienced post-acute sequelae of COVID-19 (PASC), which often affected quality of life.”
A significant portion of people with systemic autoimmune disease, including inflammatory arthritis and inflammatory bowel disease, experienced post-acute sequelae of COVID-19 (PASC), which often affected quality of life
Efficacy of Repeat Immunoadsorption in Post-COVID ME/CFS Patients with Elevated Β2-Adrenergic Receptor Autoantibodies: A Prospective Cohort Study
immunoadsorption (removing antibodies from blood) temporarily improves Long COVID symptoms. Strongly underlines the therapeutic potential of targeting autoimmunity:
Father prepares to lay his daughter to rest after COVID-19 complications a month after testing positive
“Amid a rise in COVID-19 cases in Alabama, one father in Arely is preparing to lay his daughter to rest.
Byron Farmer said his daughter Amber tested positive for covid about a month ago, but she just died unexpectedly from complications on Wednesday. After she came down with COVID-19, Byron told WVTM 13 his daughter never fully recovered”
Amid a rise in COVID-19 cases in Alabama, one father in Arely is preparing to lay his daughter to rest.
Byron Farmer said his daughter Amber tested positive for covid about a month ago, but she just died unexpectedly from complications on Wednesday. After she came down with COVID-19, Byron told WVTM 13 his daughter never fully recovered
Mild Primary or Breakthrough SARS-CoV-2 Infection Promotes Autoantibody Production in Individuals with and without Neuro-PASC | ImmunoHorizons | American Association of Immunologists
“In this study, we demonstrate that mild SARS-CoV-2 infection increases autoantibodies associated with rheumatic autoimmune diseases and diabetes in most individuals, regardless of vaccination status prior to infection…
…These data highlight the need for additional strategies to decrease the spread of SARS-CoV-2 such as the development of vaccines that can prevent infection rather than decrease severity of acute disease alone.”
Yes, it’s not mild. I can tell this with my own ordeal.
Yes, it’s not mild. I can tell this with my own ordeal.
I had Covid 3 times: Sept’20 (WT), Jan’ 22 (BA.2) & Feb’24 (JN.1). The last one was the least severe, but it was the one that left an indelible mark on my skin-Psoriasis, a chronic autoimmune ailment!
MDA5-autoimmunity and interstitial pneumonitis contemporaneous with the COVID-19 pandemic (MIP-C)
🚨A distinct pattern of Melanoma Differentiation-Associated protein-5-autoimmunity cases surged contemporaneously with circulation of the SARS-COV-2 virus during COVID19. Bioinformatic insights suggest a shared immunopathology with known autoimmune lung disease mechanisms.
Detailed thread on Twitter covering autoimmune encephalitis
"We may be entering an era of heightened autoimmune encephalitis. These occurrences may be post-infectious in nature at this point of the pandemic."
A Sharp Rise in Autoimmune Encephalitis in the COVID-19 Era: A Case Series
“Autoimmune encephalitis was very rare prior to the current pandemic. A sharp rise in cases has been observed from March to August of 2022 in Los Angeles.”
Autoimmune encephalitis associated with COVID-19: A systematic review - PubMed
"Our systematic review revealed evidence on AE development in patients infected with the COVID-19. Clinicians should be aware of the possible diagnosis of AE when considering other neurological differential diagnosis in SARS-CoV-2 infected patients."
Correlation of covid-19 and Guillain-Barré syndrome: A Mechanistic Perspective
"SARS-CoV-2 uses angiotensin-converting enzyme 2 as its entry receptor and enters the central nervous system.. the virus can infect peripheral neurons to cause direct damage.. the number of Guillain-Barré Syndrome patients linked to COVID19 has increased significantly."
"Two studies that use large cohorts now highlight that SARS-CoV-2 infection is linked to a substantially increased risk of developing a diverse spectrum of new-onset autoimmune diseases."
A Comprehensive Review of COVID-19–Associated Endocrine Manifestations
As result of the COVID-19 infections, "Thyroid dysfunction with subacute thyroiditis, Graves’ disease & hypothyroidism caused by primary autoimmune thyroiditis has been reported. Pancreatic damage leads to type 1 DM because of the autoimmune nature of the disease and type 2 DM because of postinflammatory insulin resistance."
COVID-19 linked to 40% increase in autoimmune disease risk in huge study
"Catching COVID-19 may raise the risk of developing autoimmune disease by 43% in the months following the infection, according to the largest study of its kind."