Comprehensive mapping of the signaling events evoked by SARS-CoV-2 variants delta and omicron in human astrocytes
Covid and Brain Damage
Thread by @ZdenekVrozina on Thread Reader App
“A new study strengthens the view that SARS-CoV-2: disrupts brain homeostasis, alters ionic & neurotransmitter balance, and triggers lasting epigenetic reprogramming. Researchers exposed human primary astrocytes to Delta and Omicron. The results are striking🧵”
A new study strengthens the view that SARS-CoV-2:
disrupts brain homeostasis,
alters ionic & neurotransmitter balance,
and triggers lasting epigenetic reprogramming.
Researchers exposed human primary astrocytes to Delta and Omicron.
The results are striking🧵
Alterations of the amygdala in post-COVID olfactory dysfunction
University Hospital Schleswig-Holstein, 61 adults about 8 months after COVID were scanned by MRI.
Those with persistent smell loss showed structural changes in the amygdala linked to smell and emotion, along with higher anxiety and depression scores.
Mechanisms of sex differences in acute and long COVID sequelae in mice
Johns Hopkins scientists found that female mice recovering from COVID showed lasting memory loss and brain inflammation.
The effect was driven by having two X chromosomes, revealing a genetic cause for why long COVID hits women harder.
COVID-19 Linked to Lasting and Underrecognized Smell Impairment
Among adults with COVlD-related changes in smell and taste, 23% experience severe or total loss.
Importantly, the cumulative burden will increase with repeat infections, it diminishes quality of life, & it indicates neurological damage.
Brainstem damage found to be behind long-lasting effects of severe Covid-19
"Using ultra-high-resolution scanners that can see the living brain in fine detail, researchers from the Universities of Cambridge and Oxford were able to observe the damaging effects Covid-19 can have on the brain."
Thread by @JamesThrot on Thread Reader App
“SARS-CoV-2 isn’t just a respiratory virus. Emerging evidence shows it can infect human motor neurons. Could this link to motor neuron disease (MND)?”
COVID-19 infection associated with increased risk of new-onset vascular dementia in older adults
COVID-19 infection linked to a 41% higher risk of developing new-onset vascular dementia in older adults, with researchers warning that the virus may have lasting effects on brain and vascular health even after recovery.
Scientists reveal the one Covid symptom you may be stuck with for life
“It is well known that Covid can impair your sense of smell, but a new study has found that those who lose it may never get it back.”
It is well known that Covid can impair your sense of smell, but a new study has found that those who lose it may never get it back.
COVID-19 infection associated with increased risk of new-onset vascular dementia in adults ≥50 years
UK Biobank study of 54,757 adults aged 50+ found that COVID-19 survivors had a 41% higher risk of dementia and a 77% higher risk of vascular dementia after two years, especially in those unvaccinated or with mental illness.
Thread by @IntegralAnswers on Thread Reader App
“Thread: A molecular clue to Long COVID “brain fog”
1/ New study from Yokohama City Univ used PET imaging of AMPA receptors. Long COVID patients showed elevated AMPAR levels, linked to both cognitive impairment and inflammation. A molecular biomarker emerges.”
Thread: A molecular clue to Long COVID “brain fog”
1/ New study from Yokohama City Univ used PET imaging of AMPA receptors. Long COVID patients showed elevated AMPAR levels, linked to both cognitive impairment and inflammation. A molecular biomarker emerges.
Thread by @ZdenekVrozina on Thread Reader App
“COVID and brain fog. For millions, it’s the most disabling legacy of the pandemic. Now, a new brain imaging study reveals a clear biological basis - and the parallels with other diseases are not encouraging.🧵”
COVID and brain fog.
For millions, it’s the most disabling legacy of the pandemic.
Now, a new brain imaging study reveals a clear biological basis - and the parallels with other diseases are not encouraging.🧵
Molecular Imaging Findings on Acute and Long-Term Effects of COVID-19 on the Brain: A Systematic Review
“Molecular imaging techniques such as PET and SPECT have been used to shed light on how coronavirus disease 2019 (COVID-19) affects the human brain. We provide a systematic review that summarizes the current literature according to 5 predominant topics.”
Molecular imaging techniques such as PET and SPECT have been used to shed light on how coronavirus disease 2019 (COVID-19) affects the human brain. We provide a systematic review that summarizes the current literature according to 5 predominant topics.
Systemic increase of AMPA receptors associated with cognitive impairment of long COVID | Brain Communications | Oxford Academic
“Long COVID primarily presents with persistent cognitive impairment (Cog-LC), imposing a substantial and lasting global burden. Even after the pandemic, there remains a critical global need for diagnostic and therapeutic strategies targeting Cog-LC.”
Long COVID primarily presents with persistent cognitive impairment (Cog-LC), imposing a substantial and lasting global burden. Even after the pandemic, there remains a critical global need for diagnostic and therapeutic strategies targeting Cog-LC.
New study reveals molecular basis of Long COVID brain fog
“the researchers found a notable and widespread increase in the density of AMPARs across the brains of patients. This elevated receptor density was directly correlated with the severity of their cognitive impairment, suggesting a clear link between these molecular changes and the symptoms. Additionally, the concentrations of various inflammatory markers were also correlated with AMPAR levels, indicating a possible interaction between inflammation and receptor expression.”
Nearly 7 in 10 COVID survivors tested didn't know they had a dulled sense of smell | CIDRAP
Nearly 7 in 10 COVID survivors tested didn't know they had a dulled sense of smell.
"Even if they don't notice it, COVID-19 survivors' sense of smell may remain impaired for years after infection"
Smell Loss May Linger for Years After COVID
SARS-CoV-2 Orf6 Triggers MTCH1-Dependent Mitochondrial Dysfunction and Necroptosis in Human Neurons | Research Square
A new preprint study shows that the SARS-CoV-2 protein ORF6 directly kills human neurons. Not by accident, but through necroptosis - a kind of cell death where neurons burst and fuel inflammation. This may underlie the long-term brain symptoms of Long COVID.
6-month neurological and psychiatric outcomes in 236 379 survivors of COVID-19: a retrospective cohort study using electronic health records - PubMed
COVID-19 convalescents had a greater likelihood of developing Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and stroke 6 months after infection, as compared to those affected by influenza or any other respiratory infections.
@keetmuise And we know Covid is causing them…
“I have been experiencing focal seizures since 2021—a year after my first Covid infection. My neurologist told me Covid doesn’t do this & my issues are probably anxiety.”
What the Retina Can Reveal About COVID-19’s Effect on the Brain | Being Patient
“What the Retina Can Reveal About COVID-19’s Effect on the Brain”
What the Retina Can Reveal About COVID-19’s Effect on the Brain
Clinical and CSF single-cell profiling of post-COVID-19 cognitive impairment
we found that cognitive dysfunction is common; is not influenced by mood, fatigue, or sleepiness; and is correlated with MRI changes in very few people. In a subgroup that
An Amyloidogenic Fragment of the Spike Protein from SARS-CoV-2 Virus Stimulates the Aggregation and Toxicity of Parkinson’s Disease Protein Alpha-Synuclein
“Overall, our findings raise compelling questions about the potential role of SARS-CoV-2 infection in accelerating or triggering neurodegenerative diseases linked to protein amyloidosis”
Thread by @JamesThrot on Thread Reader App
“Covid damages the part of your brain (frontal lobe) which is responsible for empathy, emotional regulation & overcoming self-centeredness.
This will facilitate immorality.
Each & every infection you have causes damage.
Many are on infection 4 (or more).
Signed, a neurologist.”
It’s very frightening for many to even consider that #COVID infections are causing neurological damage but there are scans now. It’s impacting the frontal lobe. This is going to change society. The sooner we confront this the better or the damage will continue.🧵
“It’s very frightening for many to even consider that #COVID infections are causing neurological damage but there are scans now. It’s impacting the frontal lobe. This is going to change society. The sooner we confront this the better or the damage will continue.🧵”
A Peripheral Neuron-to-Microglia Signaling Axis Connecting Transient Viral Infection to Persistent Neuroinflammatory States | Research Square
How does a transient viral infection like COVID lead to long lasting neurologic symptoms?
In humans and in animal models, SARS-CoV-2 can damage peripheral sensory nerves in the nose, leaving behind debris that can then trigger inflammation in brain microglia for weeks to months after infection, which can then lead to post-viral neurological symptoms like cognitive dysfunction (brain fog).
The peripheral neuron-to-microglia axis offers a potential explanation for persistent inflammation seen in conditions like Long COVID and ME/CFS.
Neuropsychiatric Risks Linked to COVID-19 Revealed
New Nature study shows SARS2 significantly elevates the risk of neuropsychiatric conditions including anxiety, mood disorders, cognitive impairment and psychotic disorders for up to 6 months.
“Alarmingly, even individuals with mild or asymptomatic infections face elevated risk.”
Mental and neurological disorders and risk of COVID-19 susceptibility, illness severity and mortality: A systematic review, meta-analysis and call for action
184 - Brain Health Breakthrough with Dr Henry Mahncke & Dr Gitendra Uswatte
Thread by @JamesThrot on Thread Reader App
“Let’s talk about COVID, brain damage & society.
Specifically, what happens when a neurotropic virus repeatedly infects the population, targeting the frontal lobe & almost nobody talks about the consequences?
This thread is for the skeptics.
I’m a neurologist, stay with me 🧵”
Let’s talk about COVID, brain damage & society.
Specifically, what happens when a neurotropic virus repeatedly infects the population, targeting the frontal lobe & almost nobody talks about the consequences?
This thread is for the skeptics.
I’m a neurologist, stay with me 🧵