SARS-CoV-2, long COVID, prion disease and neurodegeneration
SARS-CoV-2, long COVID, prion disease and neurodegeneration
Covid and Brain Damage
Chris Turnbull on Twitter
Comprehensive thread on possible prion involvement with SarsCov2 Mad Cov-Disease? New study looks at the possibility that Covid is a prion (a type of protein that can cause degenerative brain diseases such as Creutzfeldt-Jakob disease (CJD) aka mad Cow disease
Is Long Covid a prion disease?
Potential Prion Involvement in Long COVID-19 Neuropathology, Including Behavior
"Potential Prion Involvement in Long COVID-19 Neuropathology, Including Behavior"
UCSD Scientists Find COVID Damages Brain Cell Synapses, But Propose Treatment
“an FDA-approved antiviral drug might be repurposed to restore infected brain cells to health.. sofosbuvir — already an approved treatment for hepatitis C – – effectively inhibited SARS-CoV-2 replication and reversed damages in infected brain organoids.”
Cognitive impairment in young adults with post COVID-19 syndrome
Covid cognitive impairment in young adults: concentration difficulties (87.85%), anomia/word-finding difficulties in speech (86.44%), processing speed/remembering recent events (76.16%), multitasking (75.23%) reading aloud/reading comprehension (69.62%).
Study: Parts of COVID-19 may stay in brain long after infection
"A recent study found parts of the COVID-19 virus may remain in the brain long after a person has recuperated from the infection."
Effects of post-acute COVID-19 syndrome on the functional brain networks of non-hospitalized individuals
"...physiological recovery from COVID-19 may extend well beyond the resolution of acute symptoms, with the persistence of post-COVID brain changes raising particular concerns about the cumulative effects of repeated infection on brain function"
Canadian neurocognitive disorder expert speaks to Global Workers Inquest into the Pandemic: “To say ‘they are old, they can die’—it’s criminal”
"The impact I am seeing on my clients post-COVID is something I hadn’t seen previously in the years I have worked in this field. The cognitive decline post-COVID infection is immense, thus confirming the impact this virus has on the brain..."
Mild Covid infection can shrink brain by up to 2%, reveals study | Hyderabad News - Times of India
Mild Covid infection can shrink brain by up to 2%
COVID-19 Strikes Again: Accelerating Dementia in the Most Vulnerable
"A study published in the Journal of Alzheimer’s Disease Reports reveals that infection with SARS-CoV-2 significantly impacts cognitive function in patients with preexisting dementia, causing rapidly progressive dementia."
Had COVID? Part of the Virus May Stick Around in Your Brain
"Had COVID? Part of the Virus May Stick Around in Your Brain
Researchers in Germany found that part of the virus, the spike protein, remains in the brain long after the virus clears out..."
Cerebral hypoperfusion in post-COVID-19 cognitively impaired subjects revealed by arterial spin labeling MRI
New paper comparing #LongCovid patients to matched controls found significantly reduced blood flow all over the brain - frontal, temporal, & parietal lobes.
Middle column in the picture below are healthy controls; red/warm colors = more blood flow. 1/
Cerebral hypoperfusion in post-COVID-19 cognitively impaired subjects revealed by arterial spin labeling MRI
Study examining patients at a long COVID neurology clinic showing deficits in executive, attention, language and memory functions. MRIs showed reduced blood flow to frontal, parietal and temporal regions of the brain compared to age & sex matched controls
Tatiana Prowell, MD on Twitter
A study from #Brazil finds 1 in 4 adults who had mild #COVID19 demonstrated cognitive deficits. The average age of study participants was 38. See what happened when they were asked to copy a diagram. We are not prepared for this.
New study shows SARS-CoV-2 infection accelerates the progression of dementia
"All subtypes of dementia, irrespective of patients’ previous dementia types, behaved like rapidly progressive dementia following COVID-19, according to the Journal of Alzheimer’s Disease Reports"
COVID-19 delirium and encephalopathy: Pathophysiology assumed in the first 3 years of the ongoing pandemic
COVID-19 delirium and encephalopathy: Pathophysiology assumed in the first 3 years of the ongoing pandemic.
The Risks of Even Mild COVID-19: 1 in 4 Showing Cognitive Deficits After Mild Case, Brazilian Study Finds
"new research suggests even a mild SARS-CoV-2 infection could lead to persistent and even long-term consequences, some that may not be known for years or even decades... 'under-studied' groups: those with mild-COVID-19 and children."
Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses
Para-infectious brain injury in COVID19 persists at follow-up despite attenuated cytokine & autoantibody responses: brain injury biomarkers (Tau, GFAP, NfL, UCH-L1) were⬆️in acute sera,signif⬆️ for NfL & UCH-L1, in altered consciousness.
Eric Topol on Twitter
Important new report on #LongCovid and the brain demonstrating persistence of the virus spike protein, throughout the body and particularly the skull-meninges axis, both in humans and the mouse model
Ali M. Erturk on Twitter
60% of us who had COVID still might have lingering viral spikes in our heads! Our new study reveals SARS-CoV-2 spike accumulation in the skull-meninges-brain axis & its implications in long COVID. By @zhouyi_rong
@HongchengM
@Sakethkapoor 🔬🧠🦠🧵👇
COVID-19 Infection Accelerates the Progression of Dementia - Neuroscience News
"Following COVID-19 infection, all subtypes of dementia, irrespective of a person’s previous dementia type, behave like rapidly progressive dementia."
SARS-CoV-2 Spike protein alters microglial purinergic signaling
"Evidence demonstrates that SARS-CoV-2 Spike protein can reach different brain regions, irrespective of viral brain replication resulting in activation of pattern recognition receptors (PRRs) and neuroinflammation."
laurie allee on Twitter
"Evidence demonstrates that SARS-CoV-2 Spike protein can reach different brain regions, irrespective of viral brain replication resulting in activation of pattern recognition receptors (PRRs) and neuroinflammation."
SARS-CoV-2 infection induces dopaminergic neuronal loss in midbrain organoids during short and prolonged cultures
This study expands the knowledge about the neurodegenerative process that the SARS2 virus can induce, especially to dopaminergic neurons, highlighting the importance of long-term neurological impairment in COVID-19 patients.
The effects of COVID-19 on cognitive performance in a community-based cohort: A COVID Symptom Study Biobank observational study
"Cognitive deficits following SARS-CoV-2 infection were detectable nearly two years post infection, and largest for individuals with longer symptom durations, ongoing symptoms, and/or more severe infection."
Andrew Ewing on Twitter
Detailed, comprehensive Twitter thread on Covid and the brain: 1/55 Covid and the brain. An update of my January 29 2022 thread (linked). A lot of new science, some therapy suggestions. Peer reviewed, preprints, news commentaries, videos. 55 tweets.
'I'm an artist but long covid has made my face blindness even worse'
'I'm an artist but long Covid has made my face blindness even worse - sometimes I even struggle to recognise friends'
'Renowned illustrator Stanley Chow has opened up on his experiences living with 'face blindness' as scientists in the US..
Woman develops 'face blindness' at 28. Researchers think COVID-19 is cause
" a severe case of face blindness in a young woman following infection with Covid...study indicates that COVID-19 can cause severe and persistent neuropsychological problems, including deficits in facial recognition and navigation" abilities."
laurie allee on Twitter
Starting thread on Prosopagnosia or "face blindness" after Covid infection.
BIRCH on Twitter
Even mild Covid can cause impairments with all five of your senses for long periods after the initial infection. *all images available as editable, printable files, DM for info.