Covid and Brain Damage

Covid and Brain Damage

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Omicron better at invading young noses than other variants; smell loss may predict memory issues | Inquirer News
Omicron better at invading young noses than other variants; smell loss may predict memory issues | Inquirer News

Brain damage after even mild Covid in kids: Omicron is much better at invading children's noses, predicts memory issues. "Severity of smell dysfunction after infection may be a better predictor of long-term cognitive impairment than severity of COVID-19"

·newsinfo.inquirer.net·
Omicron better at invading young noses than other variants; smell loss may predict memory issues | Inquirer News
COVID Virus May Tunnel through Nanotubes from Nose to Brain
COVID Virus May Tunnel through Nanotubes from Nose to Brain

"COVID Virus May Tunnel through Nanotubes from Nose to Brain

Nanotubes may provide a cunning answer to the mystery of how the virus that causes COVID infects neurons and produces long-lasting neurological symptoms"

·scientificamerican.com·
COVID Virus May Tunnel through Nanotubes from Nose to Brain
Michelle Monje on Twitter
Michelle Monje on Twitter

Thread on Twitter: How might even mild respiratory #COVID infection affect the brain? Using a mouse model of mild SARS-CoV-2 infection limited to the respiratory system, we found elevation of CNS cytokines/chemokines and white matter-specific microglial reactivity. 3/

·twitter.com·
Michelle Monje on Twitter
Even Mild COVID-19 May Change the Brain
Even Mild COVID-19 May Change the Brain
"A large study comparing brain scans from the same individuals before and after SARS-CoV-2 infection suggests that brain changes could be a lingering outcome of even mild COVID-19"
·jamanetwork.com·
Even Mild COVID-19 May Change the Brain
40% of Older Adults: Newly Identified Form of Dementia Is Shockingly Common
40% of Older Adults: Newly Identified Form of Dementia Is Shockingly Common
A recent study indicates the prevalence of #brain changes from #limbic-predominant age-related TDP-43 #encephalopathy (#LATE) might be approximately 40% in older adults and as high as 50% in people with #Alzheimer’s disease..."
·scitechdaily.com·
40% of Older Adults: Newly Identified Form of Dementia Is Shockingly Common
SARS-CoV-2 is associated with changes in brain structure in UK Biobank
SARS-CoV-2 is associated with changes in brain structure in UK Biobank

UK researchers scanned the brains of 400 people before and after mild covid, compared them with controls and found:

  1. greater reduction in grey matter thickness
  2. greater reduction in global brain size
  3. greater cognitive decline
  4. greater change to primary olfactory cortex
·nature.com·
SARS-CoV-2 is associated with changes in brain structure in UK Biobank
COVID-19 and neurodegenerative diseases
COVID-19 and neurodegenerative diseases
"many patients with COVID-19 experience a variety of neurological complications...possible mechanisms between COVID-19 and several typical neurodegenerative diseases, particularly Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis"
·europeanreview.org·
COVID-19 and neurodegenerative diseases
Selective visuoconstructional impairment following mild COVID-19 with inflammatory and neuroimaging correlation findings
Selective visuoconstructional impairment following mild COVID-19 with inflammatory and neuroimaging correlation findings
"investigate adults at least four months after recovering from mild COVID-19...In approximately 1/4 of mild-COVID-19 individuals, we detected a specific visuoconstructive deficit, which was associated with changes in molecular and structural brain imaging"
·nature.com·
Selective visuoconstructional impairment following mild COVID-19 with inflammatory and neuroimaging correlation findings
Hiroshi Yasuda (保田浩志) on Twitter
Hiroshi Yasuda (保田浩志) on Twitter

According to a systematic review on the COVID-19 survivors, "Seventy-nine percent of COVID-19 survivors at 1 months and 75% at 3- and 6-month follow-up showed cognitive impairment.."

3 in 4 is a quite high ratio.

·twitter.com·
Hiroshi Yasuda (保田浩志) on Twitter
S0092 8674(22)00713 9#
S0092 8674(22)00713 9#
"Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation"
·cell.com·
S0092 8674(22)00713 9#
You're not imagining 'COVID brain' — here's the latest evidence
You're not imagining 'COVID brain' — here's the latest evidence

COVID cognitive decline more widespread than thought say researchers at Australia's first long-COVID clinic Some sort of cognitive decline was recorded in almost all of the participants, regardless of the severity of the initial infection.

·abc.net.au·
You're not imagining 'COVID brain' — here's the latest evidence
Andrew Ewing on Twitter
Andrew Ewing on Twitter

Comprehensive thread on Twitter 1/36 Update of the covid and the brain talk I recently gave to Drs at Select Medical Better quality figures More on references to look up: Lancet, NEJM, Nature, Neurology, etc Some new material dispersed and at end Some thoughts on possible treatments (not my expertise)

·twitter.com·
Andrew Ewing on Twitter
Rapid vigilance and episodic memory decrements in COVID-19 survivors
Rapid vigilance and episodic memory decrements in COVID-19 survivors

Excellent study from Oxford💥💥 This is the first report describing deficits in sustained attention & episodic memory amongst mildly-affected #COVID19 survivors long after the acute illness, in people who were not complaining of long-COVID symptoms

·academic.oup.com·
Rapid vigilance and episodic memory decrements in COVID-19 survivors