Pnas
SARS-CoV-2 is able to reach CNS of COVID-19 patients, infect astrocytes,and impair neuronal function/viability, contributing to the alterations of brain structure thereby resulting in neurocognitive/neuropsychiatric dysfunctions.
Covid and Brain Damage
Neurovascular injury with complement activation and inflammation in COVID-19
The microvascular injury and inflammation of the brain, with immune complex formation, that can occur from Covid, from in-depth assessment of 9 patient autopsies and controls.
Loss Of Smell Linked To Long Term Covid Cognitive Impairment
"Instead of disease severity, loss of smell seems a more promising avenue for predicting who develops persistent cognitive changes after SARS-CoV-2 infection."
Loss Of Smell Linked To Long Term Covid Cognitive Impairment
COVID Affects Executive Functioning in Young to Middle-Age Adults
"People who have had prior SARS-CoV-2 infection report significantly more symptoms of cognitive dysfunction and specifically executive dysfunction than people in the general population with no such infection..."
Psychosis in the Patient With COVID-19: An Emerging Psychopathology?
"COVID-19 can cause severe neuropsychological stress-inducing psychosis in affected patients...there has been an increase in the rate of psychotic symptoms such as paranoia, delusions of persecution, and auditory and visual hallucinations..."
Dr K Fearnley on Twitter
Attention medics. Does your patient have new-onset psychosis? hallucinations? personality changes post Covid?
They have neuro inflammation Encephalitis is not uncommon in #LongCovid, esp in the first months post infection. Psych is not appropriate. #MedTwitter #MedEd #TeamGP
Abdul Mannan Baig. (Ph.D.),(MBBS) on Twitter
Paper in JAMA neurology confirming my findings that were published 2.5 years back....They damage the CNS via olfactory route.
Neuropathology and virus in brain of SARS-CoV-2 infected non-human primates
Brain damage “was observed in all infected animals, regardless of disease severity, suggesting reduced brain oxygen may be a common complication of infection.”
![[Long COVID: Pathogenesis and Therapeutic Approach] - PubMed](https://rdl.ink/render/https%3A%2F%2Fcdn.ncbi.nlm.nih.gov%2Fpubmed%2Fpersistent%2Fpubmed-meta-image.png?width=350&height=&ar=16:9&mode=crop&format=avif&dpr=2)
[Long COVID: Pathogenesis and Therapeutic Approach] - PubMed
"Several imaging studies have shown that long COVID cases present with decreased glucose metabolism & progressive brain atrophy.. no definitive consensus has been reached due to the complexity & diversity.."
COVID-PARKINSON’S LINK - News Services
"...analysis of nearly one million Danish health records that found COVID-19 patients were more likely to be diagnosed with Parkinson’s disease, as well as Alzheimer’s disease, stroke and bleeding in the brain."
Potential autonomic nervous system dysfunction in COVID-19 patients detected by heart rate variability is a sign of SARS-CoV-2 neurotropic features - PubMed
New: Neurotropism and presence of SARS-COV-2 protein in brainstem/probable effect on autonomic nervous system.
Covid study finds millions have long-term smell or taste problems
"Covid study finds millions have long-term smell or taste problems
Researchers say about 5% of infected adults may develop long-lasting changes to sense of smell or taste"
Omicron better at invading young noses than other variants; smell loss may predict memory issues | Inquirer News
Brain damage after even mild Covid in kids: Omicron is much better at invading children's noses, predicts memory issues. "Severity of smell dysfunction after infection may be a better predictor of long-term cognitive impairment than severity of COVID-19"
Common viruses may be triggering the onset of Alzheimer’s disease
"... researchers also noted the #long_term #neurological effects that some COVID patients have experienced from the #SARSCoV2 virus, particularly among the elderly, and that both #VZV and #HSV_1 can be reactivated after a #COVID #infection."
COVID Virus May Tunnel through Nanotubes from Nose to Brain
"COVID Virus May Tunnel through Nanotubes from Nose to Brain
Nanotubes may provide a cunning answer to the mystery of how the virus that causes COVID infects neurons and produces long-lasting neurological symptoms"
Michelle Monje on Twitter
Thread on Twitter: How might even mild respiratory #COVID infection affect the brain? Using a mouse model of mild SARS-CoV-2 infection limited to the respiratory system, we found elevation of CNS cytokines/chemokines and white matter-specific microglial reactivity. 3/
Even Mild COVID-19 May Change the Brain
"A large study comparing brain scans from the same individuals before and after SARS-CoV-2 infection suggests that brain changes could be a lingering outcome of even mild COVID-19"
Willow on Twitter
29 months of #LongCovid after a "mild" onset. Here are 3 of my 4 inoperable #brainAneurysms, lesions, volume loss, & brain damage after strokes caused by Covid. #longcovidbraindamage #stroke #covidbraindamage
Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation
"Mild respiratory COVID causes prominent neuroinflammation..."
laurie allee on Twitter
How #SARSCoV2 infects/affects brain astrocytes https://pnas.org/doi/10.1073/pnas.2122236119 @PNASNews by @Andrews_MG
@tmturkee
@TheOttolab
@Kriegsteinlab and colleagues
Pnas
How #SARSCoV2 infects/affects brain astrocytes
Mild to moderate COVID causes inflammation of white matter in brain ten months later
"...results of this study suggest that mild to moderate COVID-19 infection is associated with mild microstructural abnormalities in cerebral white matter after acute infection."
COVID Brain Problems May Stem From Attack on Endothelial Cells
"COVID Brain Problems May Stem From Attack on Endothelial Cells — Findings could have implications for treating long COVID"
Neurovascular injury with complement activation and inflammation in COVID-19
"All patients had multifocal vascular damage as determined by leakage of serum proteins into the brain parenchyma. This was accompanied by widespread endothelial cell activation...microthrombi were found adherent to the endothelial cells..."
40% of Older Adults: Newly Identified Form of Dementia Is Shockingly Common
A recent study indicates the prevalence of #brain changes from #limbic-predominant age-related TDP-43 #encephalopathy (#LATE) might be approximately 40% in older adults and as high as 50% in people with #Alzheimer’s disease..."
SARS-CoV-2 is associated with changes in brain structure in UK Biobank
UK researchers scanned the brains of 400 people before and after mild covid, compared them with controls and found:
- greater reduction in grey matter thickness
- greater reduction in global brain size
- greater cognitive decline
- greater change to primary olfactory cortex
COVID-19 Linked to Significant Brain Changes, Shrinkage
Covid linked to significant brain shrinkage: "Even a mild COVID-19 infection can change the brain. People infected had a greater reduction in brain volume and performed worse on cognitive tests than those who did not contract COVID-19."
COVID-19 and neurodegenerative diseases
"many patients with COVID-19 experience a variety of neurological complications...possible mechanisms between COVID-19 and several typical neurodegenerative diseases, particularly Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis"
Selective visuoconstructional impairment following mild COVID-19 with inflammatory and neuroimaging correlation findings
"investigate adults at least four months after recovering from mild COVID-19...In approximately 1/4 of mild-COVID-19 individuals, we detected a specific visuoconstructive deficit, which was associated with changes in molecular and structural brain imaging"
Hiroshi Yasuda (保田浩志) on Twitter
According to a systematic review on the COVID-19 survivors, "Seventy-nine percent of COVID-19 survivors at 1 months and 75% at 3- and 6-month follow-up showed cognitive impairment.."
3 in 4 is a quite high ratio.