NF-κB links COVID-19 to PD | JIR
Role of Inflammation in the Development of COVID-19 to Parkinson’s Disease
Covid and Brain Damage
Unraveling the enigma of long COVID: novel aspects in pathogenesis, diagnosis, and treatment protocols
“The nervous system, particularly the brain, can become infected by SARS-CoV-2 early in the course of COVID-19 via viral access through the cribriform plate located at the upper part of the nose.. this route is more ominous than previously thought. The pits of the cribriform plate and areas beneath the olfactory bulb including potential spaces such as the air sinuses can be a reservoir for not only viral persistence, but also its replication.. the upper part of the nose and the structures surrounding it appear to be ideal sites for access to the CNS (central nervous system).. This can cause a low-grade inflammation in the meninges and deeper tissues in the neuronal environment triggering neuroinflammation.. [This can cause] Symptoms such as brain fog, cognitive deficits, prolonged anosmia, memory deficits, and deposition of amyloid-like fibrils that cause premature aging in patients with long COVID.."
It's certainly ominous that SARS-CoV-2 can infect my brain instantly and silently.”
Cell invasive amyloid assemblies from SARS-CoV-2 peptides can form multiple polymorphs with varying neurotoxicity
𝘼𝙢𝙮𝙡𝙤𝙞𝙙 𝙖𝙜𝙜𝙧𝙚𝙜𝙖𝙩𝙚𝙨 𝙛𝙧𝙤𝙢 𝙎𝘼𝙍𝙎-𝘾𝙤𝙑-2 𝙥𝙚𝙥𝙩𝙞𝙙𝙚𝙨 𝙧𝙚𝙖𝙙𝙞𝙡𝙮 𝙚𝙣𝙩𝙚𝙧 𝙣𝙚𝙪𝙧𝙤𝙣𝙖𝙡 𝙘𝙚𝙡𝙡𝙨, 𝘢𝘯𝘥 𝘵𝘩𝘪𝘴 𝘤𝘢𝘶𝘴𝘦𝘴 𝘢 𝘳𝘦𝘥𝘶𝘤𝘵𝘪𝘰𝘯 𝘪𝘯 𝘵𝘩𝘦𝘪𝘳 𝘮𝘪𝘵𝘰𝘤𝘩𝘰𝘯𝘥𝘳𝘪𝘢𝘭 𝘳𝘦𝘴𝘱𝘪𝘳𝘢𝘵𝘪𝘰𝘯.
Covid, study reveals: here's how the virus can increase Parkinson's risks
Covid, study reveals: here's how the virus can increase Parkinson's risks
SARS-CoV-2 infection as a cause of neurodegeneration
🧠 Long COVID and Your Brain 🧠
Brain abnormalities in survivors of COVID-19 after 2-year recovery: a functional MRI study
Even 27 months after recovering from COVID-19, many people still suffer from brain-related issues like cognitive failures and mental fatigue. A recent study used brain scans (fMRI) to investigate why.
Chris Turnbull on Twitter / X
Long COVID: From olfactory dysfunctions to viral Parkinsonism
Long COVID: From olfactory dysfunctions to viral Parkinsonism
“Long COVID: From olfactory dysfunctions to viral Parkinsonism”
Long COVID: From olfactory dysfunctions to viral Parkinsonism
COVID-19 Leaves Its Mark on the Brain. Significant Drops in IQ Scores Are Noted.
NYC man's fatal brain disease linked to COVID-19: 'Highly likely'
“Doctors from Mount Sinai Queens’ said it’s ‘highly likely’ COVID contributed to a New York City man developing fatal prion disease.”
Acute blood biomarker profiles predict cognitive deficits 6 and 12 months after COVID-19 hospitalization
“we identified two distinct biomarker profiles measured during the acute admission, which predict cognitive outcomes 6 and 12 months after COVID-19.”
Severe acute respiratory syndrome coronavirus 2 infection leads to Tau pathological signature in neurons
“It is now evident that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection results in a wide range of long-term neurological symptoms and is worryingly associated with the aggravation of Alzheimer’s disease. Little is known about the molecular basis of these manifestations.”
Google Scholar
importance of neuropsychology in the early rehabilitation of patients with critical illness after acute COVID infection
Google Scholar
Neurological damages in COVID‐19 patients: Mechanisms and preventive interventions
Brain Pathology in COVID-19: Clinical Manifestations and Potential Mechanisms
Even though Omicron caused less severe disease than Delta, the incidence of neurological manifestations is similar. More than 30% of patients experienced 'brain fog', delirium, stroke, and cognitive impairment, and over half of these patients presented abnormal neuroimaging outcomes.. The most frequent imaging features (affecting >60% of patients) include ischemic infarcts, intracerebral hemorrhages, perfusion abnormalities, and leptomeningeal enhancement. Hypometabolism in the pons, cerebellum, bilateral insula, bilateral medial lobes, and prefrontal cortex indicates brain function dysregulation in COVID patients. The high incidence of cerebrovascular events such as ischemic stroke and intracerebral hemorrhage, indicates potential endothelial injury and coagulation dysfunction. Other investigations have also reported hypoxic alterations in the cerebellum and cerebrum, metabolic alterations of astrocytes, microglial activation, neuro-axonal damage, and neuronal loss.."
Alix Burack on Twitter
related:
Neuroinflammation After COVID-19 With Persistent Depressive and Cognitive Symptoms
Neuroinflammation After COVID-19 With Persistent Depressive and Cognitive Symptoms
Wes Wilson on Twitter
Study from CAMH found, via PET scans, elevated levels of the protein TSPO, a brain marker of inflammation, in patients with onset of depression in long covid
more than 200 million globally may experience lingering neurological symptoms from COVID, including depression, memory impairment, slower motor control, low motivation and energy, for months to even years due to brain inflammation from long COVID
this along side everything we have learned in the last 2.5 years ( much summarized in the lit review done by Stanford and Yale, linked in the comments ) moves us a step closer in understanding the underlying biological mechanisms behind these symptoms
The negative impact of COVID-19 on working memory revealed using a rapid online quiz
“Memory scores for all COVID groups combined were significantly reduced compared to the non-COVID group in every age category 25 years and over...”
Dutch Survey Data Shows Significant Increase In Memory And Concentration Problems Among Adults Since Start Of Covid-19 Pandemic
"Dutch Survey Data Shows Significant Increase In Memory And Concentration Problems Among Adults Since Start Of Covid-19 Pandemic"
CAMH study confirms ongoing brain inflammation associated with long COVID
"What’s new about this study is that it shows that inflammation is hanging around for a long time in the brains of people with long COVID even after only mild to moderate symptoms of active COVID-19,”
Nate Bear on Twitter
Thread on Twitter: New study documents the case of two previously healthy sisters - 11 and 13-years-old - with new-onset cognitive decline after mild covid. The ability of their brains to consume glucose had been impaired - an initiating factor for dementia, Parkinson's and Alzheimer's disease 🧵
Does COVID-19 damage the brain? - Harvard Health
"Even if people escape brain damage during the initial attack of COVID-19, they remain at considerably greater risk of various brain conditions, including strokes, depression, anxiety, and psychosis for the next several years."
Brain hypoxia, neurocognitive impairment, and quality of life in people post-COVID-19
"We report that there was brain hypoxia in approximately 24% of individuals who were at least 8 weeks post-COVID-19 infection, despite normal arterial saturation and no signs of fever."
Unmasking Long COVID: How SARS-CoV-2 Plays Mind Tricks With Your Pain
"study...has revealed that SARS-CoV-2 infection can lead to lasting damage to the dorsal root ganglia, resulting in Post-COVID Conditions or Long COVID..."
Harry Spoelstra on Twitter
Interesting study: Inflammatory and mental health sequelae of COVID-19
"The COVID-19 pandemic has caused significant negative consequences to mental health. Increased inflammatory factors and neuropsychiatric symptoms, such as cognitive impairment (“brain fog”), depression, and anxiety are associated with long COVID [post-acute sequelae of SARS-CoV-2 infection (PASC), termed neuro-PASC]"
➡️Biomarker: MIG
"Growing evidence supporting the usefulness of circulating MIG(monokine induced by gamma interferon (IFN-γ) aka CXCL9) levels as a biomarker reflecting IFN-γ production, which is important because individuals with neuro-#PASC/ neuro-#Longcovid have elevated IFN-γ responses to internal SARS-CoV-2 proteins"
Study: COVID-19 Can Accelerate Brain Aging, Lead to Irreversible Neurological Conditions
“Tiny leakages of blood in crucial brain regions of patients infected with Covid-19 can accelerate brain aging and lead to irreversible neurodegenerative conditions, according to a Houston Methodist review study.”
Study found long-term brain damage associated with COVID-19, not vaccine | Fact check
"We have done zero experiments using the vaccine, and we have shown and claim zero side effects of the vaccine...Our work reports the presence of the spike protein in the skull of deceased individuals long after their COVID-19 infection"
laurie allee on Twitter
"This comprehensive analysis of patients with neuro-PASC revealed a disabling but difficult to characterize syndrome that develops even after relatively mild COVID-19. A common feature is memory impairment."