Daniel Brittain Dugger on Twitter
It ain't brain fog. It is SARS-Cov-2 Associated Neurocognitive Decline (SAND) and we are not moving fast enough.
Covid and Brain Damage
Even mild Covid is linked to brain damage months after illness, scans show
Even mild Covid is linked to brain damage, scans show
Roland Baker on Twitter
Comprehensive explainer thread: Nature: Enhanced replication of SARS-CoV-2 Omicron BA.2 in human forebrain and midbrain organoids: BA.2 replicated more efficiently & triggered substantially higher levels of apoptosis (cell death) in the infected human forebrain and midbrain organoids.
Enhanced replication of SARS-CoV-2 Omicron BA.2 in human forebrain and midbrain organoids
BA.2 triggered higher levels of these pro-apoptotic genes CHOP and PUMA in both forebrain and midbrain organoids compared with SARS-CoV-2 WT, Delta, and BA.1. [Pro-apoptotic means enabling programmed cell death].
How COVID-19 causes neurological damage
"researchers led by Professor Gregor Hutter from the Department of Biomedicine at the University of Basel and University Hospital of Basel have reported new insights into the development of 'neuro-Covid' in the journal Nature Communications."
COVID-19 amplifies damage to the central nervous system in Alzheimer's disease
"COVID-19 amplifies damage to the central nervous system in Alzheimer's disease"
![How Does COVID-19 Harm Brain? Scientists Find Mechanisms Associated With Neurological Damage [Study]](https://rdl.ink/render/https%3A%2F%2Fdata1.ibtimes.co.in%2Fen%2Ffull%2F760064%2Fbrain.jpg?width=350&height=&ar=16:9&mode=crop&format=avif&dpr=2)
How Does COVID-19 Harm Brain? Scientists Find Mechanisms Associated With Neurological Damage [Study]
"According to researchers, COVID-19 patients struggling with severe neurological symptoms exhibit signs of impairment in the blood-brain barrier, and changes in brain structure..."
UCSD research finds COVID damages brain cell synapses
"An international team of researchers led by scientists at UC San Diego School of Medicine has shown that the virus which causes COVID-19 can damage brain cell synapses, according to a report published Thursday."
Like a "fire in the brain": COVID can cause brain inflammation
"A new study in the journal Molecular Psychiatry shows for the first time that SARS-2 can trigger the same inflammatory processes seen in patients with Alzheimer's or Parkinson's."
Long Covid changes the human brain. We may finally know how
"Long Covid changes the human brain. We may finally know how
Lost connections between nerve cells in the brain may explain cognitive symptoms such as brain fog and memory lapses."
'A silent killer': COVID-19 shown to trigger inflammation in the brain
Another study showing that metabolic pathways activated in brain by covid are similar to the ones that happen in Alzheimer & Parkinson diseases. While the drugs to stop this inflammation are being tested, the inflammation is affecting millions of ppl.
Brazilian study reveals the effects of SARS-CoV-2 infection on the central nervous system
"COVID-19 can infect brain cells, especially astrocytes...Research also broke new ground by describing alterations in the structure of the cortex, the most neuron-rich brain region, even in cases of mild COVID-19."
Long COVID Experts: ‘So Incredibly Clear What’s at Stake’
"It is estimated that more than 1/3 of people who have had COVID-19 also have neurological complications that persist or develop 3 months after infection. And 2/3 of people with long COVID still have neurological symptoms after 6 months"
Study explores COVID-19 effects on cognition
"The study also found that the degree of cognitive impairment was not related to the amount of time that had elapsed between COVID-19 infection and the assessment, suggesting that they might be long-lasting."
Long COVID smell loss linked to changes in the brain
"The findings suggest smell loss, known as anosmia, caused by long COVID is linked to a change in the brain that stops smells from being processed properly"
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Starting thread on potential treatments for anosmia / parosmia (loss of/altered smell & taste) "Randomized clinical trial olfactory dysfunction after COVID-19: olfactory rehabilitation therapy vs. intervention treatment w/ Palmitoylethanolamide & Luteolin"
Brain imaging before and after COVID-19 in UK Biobank
"These brain imaging result...hallmarks of a degenerative spread of the disease — or of the virus itself — via olfactory pathways...or of neuroinflammatory events due to the infection, or of the loss of sensory input due to anosmia."
I recovered from COVID but my nose didn't. Here's how I cope
"Roughly 5% of people who experience smell loss during COVID-19 will develop long-term anosmia, according to Dr. Bradley J. Goldstein, an ear, nose and throat doctor at Duke University Hospital.
The impact is more drastic than most people realize."
laurie allee on Twitter
Starting thread on Covid-induced anosmia
Long Covid: What science has learned about the loss of smell and taste | CNN
2022 study: At least 5% of global Covid-19 survivors have developed long-lasting taste & smell problems... researchers found an estimated 15 million people still have problems perceiving odors, while 12 million struggle with taste.
COVID-19 Virus Infects Neurons, Induces Inflammation in the Brains of Rhesus Macaques
"A new study in rhesus macaques shows how the COVID-19 virus can enter the brain and cause inflammation of brain cells"
laurie allee on Twitter
Starting thread on Covid-induced schizophrenia
Neurovascular Injury Evident in Sudden Death of Patients With COVID-19
"Neurovascular injury during COVID-19 infection is likely triggered by antibody-mediated cytotoxicity directed at endothelial cells."
COVID-19 infection in crucial brain regions may lead to accelerated brain aging
"COVID-19 infections may predispose individuals to developing irreversible neurological conditions, may increase the likelihood of strokes and may increase the chance of developing persistent brain lesions that can lead to brain bleeding."
Eric Topol on Twitter
The biologic underpinnings of #LongCovid neurologic sequelae https://cell.com/neuron/fulltext/S0896-6273(22)00910-2 @NeuroCellPress by @michelle_monje and @VirusesImmunity
S0896 6273(22)00910 2#related articles
Comprehensive thread on Twitter> Glad to share this Perspective written with @VirusesImmunity , where we review what is understood about how COVID can affect the brain, discuss the possible neurobiological underpinnings & propose the main mechanisms that may contribute to COVID brain fog🧵
COVID increases risk of 44 different neuro disorders, including Alzheimer's, 1 year post-infection
"COVID increases risk of 44 different neuro disorders, including Alzheimer's, 1 year post-infection"
Study Reveals Main Target of COVID-19 in Brain and Describes Effects of Virus on Nervous System - Neuroscience News
"The capacity of SARS-CoV-2 to infect brain tissue and its preference for astrocytes were confirmed by Adriano Sebolella and his group at FMRP-USP"
COVID raises risk of long-term brain injury, large U.S. study finds
"COVID raises risk of long-term brain injury, large U.S. study finds"
Brain injury a common consequence of both COVID-19 and influenza
"The present study demonstrated elevated concentrations of brain injury biomarkers in COVID-19 patients...correlated with the presence of autoantibodies and proinflammatory cytokines...(and) evidence of dysregulated immune response even after four months"