Covid and Cancer

Covid and Cancer

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MSN
MSN
Unusual’ cancers emerged after the pandemic. Doctors ask if covid is to blame.
·msn.com·
MSN
Transfected SARS-CoV-2 spike DNA for mammalian cell expression inhibits p53 activation of p21(WAF1), TRAIL Death Receptor DR5 and MDM2 proteins in cancer cells and increases cancer cell viability after chemotherapy exposure - PubMed
Transfected SARS-CoV-2 spike DNA for mammalian cell expression inhibits p53 activation of p21(WAF1), TRAIL Death Receptor DR5 and MDM2 proteins in cancer cells and increases cancer cell viability after chemotherapy exposure - PubMed
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and COVID-19 infection has led to worsened outcomes for patients with cancer. SARS-CoV-2 spike protein mediates host cell infection and cell-cell fusion that causes stabilization of tumor suppressor p53 protein.
·pubmed.ncbi.nlm.nih.gov·
Transfected SARS-CoV-2 spike DNA for mammalian cell expression inhibits p53 activation of p21(WAF1), TRAIL Death Receptor DR5 and MDM2 proteins in cancer cells and increases cancer cell viability after chemotherapy exposure - PubMed
Jco
Jco
"39 (58%) patients (with glioma) experienced tumor progression following COVID-19 infection at a median of 34 days after testing positive for COVID-19.. 22 patients had measurably increased tumor area by a median of 63%; 18 of which constituted hyperprogression; 16 patients developed multifocal disease; 8 developed new nodular enhancement; 3 developed leptomeningeal disease (LMD); and 2 experienced increased infiltrative disease alone. 10 patients’ presentation with new glioma was preceded by COVID-19 infection by a median of 31 days. GBM (glioblastoma) patients represented the majority of progression events, among whom 59% progressed within 60 days of documented infection.. Glioma patients appear to have disease progression at an accelerated pace in the first two months after COVID-19 infection."
·ascopubs.org·
Jco
Denise Dewald, MD 🗽 on Twitter
Denise Dewald, MD 🗽 on Twitter

SARS-CoV-2 down-regulates p53 cancer suppressor gene expression for at least 6 months.

I don’t even want to think about what repeated infections every few months could do to the cancer rate.

Yet another reason to avoid infection. #BringBackMasks

·twitter.com·
Denise Dewald, MD 🗽 on Twitter
SARS-CoV-2 (COVID-19) Morbidity and Chronic Disease (Type II Diabetes –T2D) and Pancreatic Carcinoma: Clinco-epidemiologic Perspective
SARS-CoV-2 (COVID-19) Morbidity and Chronic Disease (Type II Diabetes –T2D) and Pancreatic Carcinoma: Clinco-epidemiologic Perspective
"COVID-19 may increase pancreatic neoplasm in populations with increased incidence of COVID-19, due to pancreatic beta cells and insulin receptors dysregulation and cellular dysfunctionality as abnormal cellular proliferation.."
·esmed.org·
SARS-CoV-2 (COVID-19) Morbidity and Chronic Disease (Type II Diabetes –T2D) and Pancreatic Carcinoma: Clinco-epidemiologic Perspective
Disseminated Kaposi sarcoma following COVID-19 in a 61-year-old Albanian immunocompetent man: a case report and review of the literature - European Journal of Medical Research
Disseminated Kaposi sarcoma following COVID-19 in a 61-year-old Albanian immunocompetent man: a case report and review of the literature - European Journal of Medical Research
Disseminated Kaposi sarcoma following COVID-19 in a 61-year-old Albanian immunocompetent man: a case report and review of the literature
·eurjmedres.biomedcentral.com·
Disseminated Kaposi sarcoma following COVID-19 in a 61-year-old Albanian immunocompetent man: a case report and review of the literature - European Journal of Medical Research
Dr Elisa Perego on Twitter
Dr Elisa Perego on Twitter
"17 cell cycle-related genes were up-regulated in SARS-CoV-2 patients [list] dysregulation in the expression of these genes is linked with various cancers, like breast cancer, digestive tract cancer, bone cancer, endometrial cancer, skin cancer, brain cancer, lung cancer etc."
·twitter.com·
Dr Elisa Perego on Twitter
Renaissance Man - Tomo IV on Twitter
Renaissance Man - Tomo IV on Twitter

“Our findings suggest that SARS-CoV-2 can be considered a potential risk factor for increasing the probability of developing cancer.”

💥💥💥💥💥💥💥💥💥

Told you it was ONCOGENIC!!!!!!!!!!!!!!!!!!!!

Long AGO!!!!!!!!!!!!!!!!!!!!!!!!

·twitter.com·
Renaissance Man - Tomo IV on Twitter
Dr Elisa Perego on Twitter
Dr Elisa Perego on Twitter

A hard but necessary read for scientists and policy makers | cancer as a perspective sequelae of #LongCovid. We know already viruses like EBV (Epstein Barr) are triggers or drivers of many kinds of cancers. Would SARS-CoV-2 be any different?

🧵

·twitter.com·
Dr Elisa Perego on Twitter
Laura Miers on Twitter
Laura Miers on Twitter
“The authors of a 2022 study present a theoretical framework of how COVID-19 could influence the development of blood cancers. According to the researchers, an abnormal immune response to viral infections can indirectly trigger gene mutations that promote leukemia.”
·twitter.com·
Laura Miers on Twitter
Leukemia After COVID-19: Is There a Connection?
Leukemia After COVID-19: Is There a Connection?

Can a COVID-19 Infection Increase Your Risk of Developing Leukemia? “It’s plausible that Covid-19 could predispose your body to cancer and accelerate cancer progression.”

·healthline.com·
Leukemia After COVID-19: Is There a Connection?
There's a good chance you have a virus called CMV. It might seem to have no effect – or it might be life-changing.
There's a good chance you have a virus called CMV. It might seem to have no effect – or it might be life-changing.

Related: “As CMV meddles in those processes for its own ends, it could be disrupting our body’s ability to repair its own DNA as it interacts with our cells over decades. When we lose the stability of our own genome, ‘that’s when cancer occurs.’”

·usatoday.com·
There's a good chance you have a virus called CMV. It might seem to have no effect – or it might be life-changing.
Eric Feigl-Ding on Twitter
Eric Feigl-Ding on Twitter
Cancer risk? Scientists now concerned that #SARSCoV2 virus targets / interacts with 96 cancer genes— thereby “potential impact on pathways relevant to cancer affecting cell proliferation… favoring DNA degradation, preventing repair of damaging events”.
·twitter.com·
Eric Feigl-Ding on Twitter
Peter English #FBPE on Twitter
Peter English #FBPE on Twitter

Some viruses are cancer-causing ("oncogenic"). HPV and anogenital and head and neck cancers, Hepatitis B and C viruses and liver cancer; Epstein Barr virus and lymphomas etc…

I'd be surprised if SARS-CoV-2 doesn't join the list.

·twitter.com·
Peter English #FBPE on Twitter
Tom Andrews on Twitter
Tom Andrews on Twitter
SARS-COV-2 causes immunopathology: the effects of COVID upon T-cells & other parts of immune system mean direct & indirect harm, lower protection against other infectious & non infectious diseases (recurrence of chronic infections, control of new cancer, recurrence of old cancer)
·twitter.com·
Tom Andrews on Twitter
Anthony J Leonardi, MBBS, PhD on Twitter
Anthony J Leonardi, MBBS, PhD on Twitter

T cells die and get depleted

If you dysregulate this you can get things like lymphoproliferation or cancers with too little death, and depletion with too much

Don't annoy me with people in denial about T cell death signatures

The findings are robust in Covid-19

·twitter.com·
Anthony J Leonardi, MBBS, PhD on Twitter
Laura Miers on Twitter
Laura Miers on Twitter

What if Covid leads to cancer later? What will we do when we already infected everyone?

Perhaps that’s why mass infection with a novel virus isn’t advisable. Some countries understand this aspect, and some countries don’t.

·twitter.com·
Laura Miers on Twitter