Possible cancer-causing capacity of COVID-19: Is SARS-CoV-2 an oncogenic agent?
Possible cancer-causing capacity of COVID-19: Is SARS-CoV-2 an oncogenic agent?
Covid and Cancer
tern on Twitter
SARS-CoV-2 can employ various strategies to potentially cause cancer in different organs.
Jco
"39 (58%) patients (with glioma) experienced tumor progression following COVID-19 infection at a median of 34 days after testing positive for COVID-19.. 22 patients had measurably increased tumor area by a median of 63%; 18 of which constituted hyperprogression; 16 patients developed multifocal disease; 8 developed new nodular enhancement; 3 developed leptomeningeal disease (LMD); and 2 experienced increased infiltrative disease alone. 10 patients’ presentation with new glioma was preceded by COVID-19 infection by a median of 31 days. GBM (glioblastoma) patients represented the majority of progression events, among whom 59% progressed within 60 days of documented infection.. Glioma patients appear to have disease progression at an accelerated pace in the first two months after COVID-19 infection."
laurie allee on Twitter
Covid and Cancer
Denise Dewald, MD 🗽 on Twitter
SARS-CoV-2 down-regulates p53 cancer suppressor gene expression for at least 6 months.
I don’t even want to think about what repeated infections every few months could do to the cancer rate.
Yet another reason to avoid infection. #BringBackMasks
SARS-CoV-2 (COVID-19) Morbidity and Chronic Disease (Type II Diabetes –T2D) and Pancreatic Carcinoma: Clinco-epidemiologic Perspective
"COVID-19 may increase pancreatic neoplasm in populations with increased incidence of COVID-19, due to pancreatic beta cells and insulin receptors dysregulation and cellular dysfunctionality as abnormal cellular proliferation.."
Disseminated Kaposi sarcoma following COVID-19 in a 61-year-old Albanian immunocompetent man: a case report and review of the literature - European Journal of Medical Research
Disseminated Kaposi sarcoma following COVID-19 in a 61-year-old Albanian immunocompetent man: a case report and review of the literature
Dr Elisa Perego on Twitter
"17 cell cycle-related genes were up-regulated in SARS-CoV-2 patients [list] dysregulation in the expression of these genes is linked with various cancers, like breast cancer, digestive tract cancer, bone cancer, endometrial cancer, skin cancer, brain cancer, lung cancer etc."
Renaissance Man - Tomo IV on Twitter
“Our findings suggest that SARS-CoV-2 can be considered a potential risk factor for increasing the probability of developing cancer.”
💥💥💥💥💥💥💥💥💥
Told you it was ONCOGENIC!!!!!!!!!!!!!!!!!!!!
Long AGO!!!!!!!!!!!!!!!!!!!!!!!!
Cancer related-genes enriched in peripheral blood mononuclear cells (PBMCs) of COVID-19 patients. a bioinformatics study
Cancer related-genes enriched in peripheral blood mononuclear cells (PBMCs) of COVID-19 patients. a bioinformatics study
Dr Elisa Perego on Twitter
A hard but necessary read for scientists and policy makers | cancer as a perspective sequelae of #LongCovid. We know already viruses like EBV (Epstein Barr) are triggers or drivers of many kinds of cancers. Would SARS-CoV-2 be any different?
🧵
Laura Miers on Twitter
“The authors of a 2022 study present a theoretical framework of how COVID-19 could influence the development of blood cancers. According to the researchers, an abnormal immune response to viral infections can indirectly trigger gene mutations that promote leukemia.”
Leukemia After COVID-19: Is There a Connection?
Can a COVID-19 Infection Increase Your Risk of Developing Leukemia? “It’s plausible that Covid-19 could predispose your body to cancer and accelerate cancer progression.”
There's a good chance you have a virus called CMV. It might seem to have no effect – or it might be life-changing.
Related: “As CMV meddles in those processes for its own ends, it could be disrupting our body’s ability to repair its own DNA as it interacts with our cells over decades. When we lose the stability of our own genome, ‘that’s when cancer occurs.’”
SARS‐CoV‐2 infection and cancer: Evidence for and against a role of SARS‐CoV‐2 in cancer onset
SARS‐CoV‐2 infection and cancer
The network of SARS-CoV-2—cancer molecular interactions and pathways
The network of SARS-CoV-2—cancer molecular interactions and pathways
Eric Feigl-Ding on Twitter
Cancer risk? Scientists now concerned that #SARSCoV2 virus targets / interacts with 96 cancer genes— thereby “potential impact on pathways relevant to cancer affecting cell proliferation… favoring DNA degradation, preventing repair of damaging events”.
Peter English #FBPE on Twitter
Some viruses are cancer-causing ("oncogenic"). HPV and anogenital and head and neck cancers, Hepatitis B and C viruses and liver cancer; Epstein Barr virus and lymphomas etc…
I'd be surprised if SARS-CoV-2 doesn't join the list.
COVID-19 May Promote Tumor Development in Patients With Cancer
or patients with existing cancer, Covid infections may promote tumor development.
Laura Miers on Twitter
“EBV is found in the bone marrow of 90% of people, CMV in 60% of people and herpes simplex in 50% of individuals in the dormant state. Herpes and CMV are found in various body parts.”
This seems important.
COVID-19: a potential driver of immune-mediated breast cancer recurrence? - Breast Cancer Research
COVID-19: a potential driver of immune-mediated breast cancer recurrence?
Tom Andrews on Twitter
SARS-COV-2 causes immunopathology: the effects of COVID upon T-cells & other parts of immune system mean direct & indirect harm, lower protection against other infectious & non infectious diseases (recurrence of chronic infections, control of new cancer, recurrence of old cancer)
Anthony J Leonardi, MBBS, PhD on Twitter
T cells die and get depleted
If you dysregulate this you can get things like lymphoproliferation or cancers with too little death, and depletion with too much
Don't annoy me with people in denial about T cell death signatures
The findings are robust in Covid-19
Laura Miers on Twitter
What if Covid leads to cancer later? What will we do when we already infected everyone?
Perhaps that’s why mass infection with a novel virus isn’t advisable. Some countries understand this aspect, and some countries don’t.
Kashyap Patel, MD, Sees Link Between COVID-19 and Cancer Progression, Calls for More Biomarker Testing
“With COVID-19 added to the mix, Patel now fears a ‘perfect storm’ of factors will trigger inflammatory responses in some patients, causing cancer to arrive years earlier than normal and making it deadlier once it is diagnosed.”
COVID-19 can lead to rapid progression of cervical intraepithelial neoplasia by dysregulating the immune system: A hypothesis
COVID-19 can lead to rapid progression of cervical intraepithelial neoplasia by dysregulating the immune system: A hypothesis Author links open overlay panel
Anthony J Leonardi, MBBS, PhD on Twitter
I can’t believe what I’m seeing
T cell dysregulation and exhaustion from Covid may have caused rapid progression of HPV related cancer
Echoing my hypothesis from three years ago
David CisMan on Twitter
p53 is also called “tumor suppressor gene”. Mutations in p53 are responsible for some family cancer syndromes.
If sars-cov-2 disrupts p53, we may be at the beginning of a very wild ride. Quote Tweet Mark Ungrin @mark_ung
p53/NF-kB Balance in SARS-CoV-2 Infection: From OMICs, Genomics and Pharmacogenomics Insights to Tailored Therapeutic Perspectives (COVIDomics)
Related: p53/NF-kB Balance in SARS-CoV-2 Infection: From OMICs, Genomics and Pharmacogenomics Insights to Tailored Therapeutic Perspectives (COVIDomics)
Cancer as a prospective sequela of long COVID-19 - PubMed
Cancer as a prospective sequela of long COVID-19