Covid and Cancer
Some viruses are cancer-causing ("oncogenic"). HPV and anogenital and head and neck cancers, Hepatitis B and C viruses and liver cancer; Epstein Barr virus and lymphomas etc…
I'd be surprised if SARS-CoV-2 doesn't join the list.
“EBV is found in the bone marrow of 90% of people, CMV in 60% of people and herpes simplex in 50% of individuals in the dormant state. Herpes and CMV are found in various body parts.”
This seems important.
T cells die and get depleted
If you dysregulate this you can get things like lymphoproliferation or cancers with too little death, and depletion with too much
Don't annoy me with people in denial about T cell death signatures
The findings are robust in Covid-19
What if Covid leads to cancer later? What will we do when we already infected everyone?
Perhaps that’s why mass infection with a novel virus isn’t advisable. Some countries understand this aspect, and some countries don’t.
COVID-19 can lead to rapid progression of cervical intraepithelial neoplasia by dysregulating the immune system: A hypothesis Author links open overlay panel
I can’t believe what I’m seeing
T cell dysregulation and exhaustion from Covid may have caused rapid progression of HPV related cancer
Echoing my hypothesis from three years ago
p53 is also called “tumor suppressor gene”. Mutations in p53 are responsible for some family cancer syndromes.
If sars-cov-2 disrupts p53, we may be at the beginning of a very wild ride. Quote Tweet Mark Ungrin @mark_ung
Related: p53/NF-kB Balance in SARS-CoV-2 Infection: From OMICs, Genomics and Pharmacogenomics Insights to Tailored Therapeutic Perspectives (COVIDomics)