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Mechanisms of gastrointestinal barrier dysfunction in COVID-19 patients
Mechanisms of gastrointestinal barrier dysfunction in COVID-19 patients

Mechanisms of gastrointestinal barrier dysfunction in COVID-19 patients

Xue W, Honda M, Hibi T.聽Mechanisms of gastrointestinal barrier dysfunction in COVID-19 patients.聽World J Gastroenterol聽2023;聽29(15): 2283-2293 [PMID: 37124884 DOI: 10.3748/wjg.v29.i15.2283]

wjgnet.com
Mechanisms of gastrointestinal barrier dysfunction in COVID-19 patients
laurie allee on Twitter
laurie allee on Twitter

Comprehensive, detailed thread on gastrointestinal effects of Covid from @GringoGranadino, one of the wonderful curators of CovidResearch.net

twitter.com
laurie allee on Twitter
Digestive system infection by SARS鈥慍oV鈥2: Entry mechanism, clinical symptoms and expression of major receptors (Review)
Digestive system infection by SARS鈥慍oV鈥2: Entry mechanism, clinical symptoms and expression of major receptors (Review)
Investigations are ongoing to determine how SARS-CoV-2 infects the gastrointestinal tract. It is known that the SARS-CoV-2 S protein binds to ACE2 of the host cell, cleaves the S protein with the help of proteases such as TMPRSS2 and then forms fusion pores to release RNA into the cytoplasm. The virus is multiplied in infected cells, which sets off an inflammatory reaction. It is not possible to rule out the possibility of SARS-CoV-2 infection when diagnosing digestive illnesses in the setting of the outbreak. The risk of SARS-CoV-2 cannot be denied, regardless of whether it directly affects the target organ, causing severe pancreatitis, gastrointestinal hemorrhage or liver damage, or whether it indirectly aggravates these conditions. Secondly, it is important to take into account both drug and viral harm to target organs while treating digestive system disorders, and to minimize the combined effects of medications.
spandidos-publications.com
Digestive system infection by SARS鈥慍oV鈥2: Entry mechanism, clinical symptoms and expression of major receptors (Review)
A descriptive study of abdominal complications in patients with mild COVID-19 presenting to the emergency department: a single-center experience in Japan during the omicron variant phase - BMC Gastroenterology
A descriptive study of abdominal complications in patients with mild COVID-19 presenting to the emergency department: a single-center experience in Japan during the omicron variant phase - BMC Gastroenterology
A descriptive study of abdominal complications in patients with mild COVID-19 presenting to the emergency department: a single-center experience in Japan during the omicron variant phase
bmcgastroenterol.biomedcentral.com
A descriptive study of abdominal complications in patients with mild COVID-19 presenting to the emergency department: a single-center experience in Japan during the omicron variant phase - BMC Gastroenterology
Gut microbiome alterations and gut barrier dysfunction are associated with host immune homeostasis in COVID-19 patients - BMC Medicine
Gut microbiome alterations and gut barrier dysfunction are associated with host immune homeostasis in COVID-19 patients - BMC Medicine

Gut microbiome alterations and gut barrier dysfunction are associated with host immune homeostasis in COVID-19 patients Our results suggest that the dysbiosis of the gut microbiome and the dysfunction of the gut barrier might play a role in the pathophysiology of COVID-19 by affecting host immune homeostasis.

bmcmedicine.biomedcentral.com
Gut microbiome alterations and gut barrier dysfunction are associated with host immune homeostasis in COVID-19 patients - BMC Medicine
17562848221118403
17562848221118403
GI symptoms in patients were seen in 12% after COVID-19 and 22% as part of long COVID. Loss of appetite, dyspepsia, irritable bowel syndrome, loss of taste, and abdominal pain were the five most common GI symptoms of long COVID. Significant heterogeneity and small number of studies for some of the analyses are limitations of the systematic review.
journals.sagepub.com
17562848221118403
S2666 6340(22)00167 2
S2666 6340(22)00167 2

Approximately one-half of COVID-19 patients shed fecal RNA in the week after diagnosis 鈥 Four percent of patients with COVID-19 shed fecal viral RNA 7 months after diagnosis 鈥 Presence of fecal SARS-CoV-2 RNA is associated with gastrointestinal symptoms 鈥 SARS-CoV-2 likely infects gastrointestinal tissue

cell.com
S2666 6340(22)00167 2
Alterations in microbiota of patients with COVID-19: potential mechanisms and therapeutic interventions
Alterations in microbiota of patients with COVID-19: potential mechanisms and therapeutic interventions
There is accumulating evidence that the microbiota are significantly altered in patients with COVID-19 and post-acute COVID-19 syndrome (PACS). Microbiota are powerful immunomodulatory factors in various human diseases, such as diabetes, obesity, cancers, ulcerative colitis, Crohn鈥檚 disease, and certain viral infections. In the present review, we explore the associations between host microbiota and COVID-19 in terms of their clinical relevance.
nature.com
Alterations in microbiota of patients with COVID-19: potential mechanisms and therapeutic interventions
Human Gut Microbiota and Its Metabolites Impact Immune Responses in COVID-19 and Its Complications
Human Gut Microbiota and Its Metabolites Impact Immune Responses in COVID-19 and Its Complications
We investigate interrelationships between gut microbes, metabolites, and cytokines that characterize COVID-19 and its complications, and we validate the results with follow-up, the Japanese 4D (Disease, Drug, Diet, Daily Life) microbiome cohort, and non-Japanese data sets.
sciencedirect.com
Human Gut Microbiota and Its Metabolites Impact Immune Responses in COVID-19 and Its Complications
Alterations in gut immunological barrier in SARS-CoV-2 infection and their prognostic potential
Alterations in gut immunological barrier in SARS-CoV-2 infection and their prognostic potential
The gastrointestinal tract may be directly infected by SARS-CoV-2 or secondarily affected by viremia and the release of inflammatory mediators that cause viral entry from the respiratory epithelium. Impaired intestinal barrier function in SARS-CoV-2 infection is a key factor leading to excessive microbial and endotoxin translocation, which triggers a strong systemic immune response and leads to the development of viral sepsis syndrome with severe sequelae.
frontiersin.org
Alterations in gut immunological barrier in SARS-CoV-2 infection and their prognostic potential
Bunk the Biologist on Twitter
Bunk the Biologist on Twitter

Analysis thread on Twitter 1/3 Viral persistence and spike shedding may decrease the amount of ACE2 in some cell types and tissues. 2012 research showed that knock-out of the ACE2 gene in mice resulted in greatly increased inflammation in the gut following intestinal damage.

twitter.com
Bunk the Biologist on Twitter
A descriptive study of abdominal complications in patients with mild COVID-19 presenting to the emergency department: a single-center experience in Japan during the omicron variant phase - BMC Gastroenterology
A descriptive study of abdominal complications in patients with mild COVID-19 presenting to the emergency department: a single-center experience in Japan during the omicron variant phase - BMC Gastroenterology
"Our study showed that acute hemorrhagic colitis was characteristic in mild cases of the omicron variant of COVID-19 with gastrointestinal bleeding."
bmcgastroenterol.biomedcentral.com
A descriptive study of abdominal complications in patients with mild COVID-19 presenting to the emergency department: a single-center experience in Japan during the omicron variant phase - BMC Gastroenterology
Johnnie Jae aka The Burnt Ball of Fury on Twitter
Johnnie Jae aka The Burnt Ball of Fury on Twitter

Anecdote This entire thread hits home. The GI issues from gastroparesis, GI bleeding and possibility of crohn's disease after having COVID is a hellscape I wasn't expecting. I expected the heart, lung and blood issues, but not the gastro issues.

twitter.com
Johnnie Jae aka The Burnt Ball of Fury on Twitter
How Long COVID Affects The Gut
How Long COVID Affects The Gut
A recent study found that people who had COVID have a 36% higher chance of developing long-term gastrointestinal problems, including disorders like gastroesophageal reflux disorder (GERD) and irritable bowel syndrome (IBS), along with more benign symptoms like constipation and diarrhea.
huffpost.com
How Long COVID Affects The Gut
COVID Raises Risk for Long-Term GI Complications
COVID Raises Risk for Long-Term GI Complications
鈥淧eople who have had COVID-19 have a 36% overall higher risk of developing gastrointestinal (GI) problems in the year after infection than people who have not had the illness, a large new study indicates.鈥 (And we know the risks increase with reinfection.)
medscape.com
COVID Raises Risk for Long-Term GI Complications
Gastrointestinal Manifestations of COVID-19
Gastrointestinal Manifestations of COVID-19
"Gastrointestinal manifestations of SARS-CoV-2 are reported in 10鈥50% of patients, being diarrhea, nausea, vomiting & abdominal pain the most frequent ones.. several studies reported ileus, intestinal ischemia, perforation & gastrointestinal bleeding.. "
link.springer.com
Gastrointestinal Manifestations of COVID-19
Comparison of thrombus, gut, and oral microbiomes in Korean patients with ST-elevation myocardial infarction: a case鈥揷ontrol study
Comparison of thrombus, gut, and oral microbiomes in Korean patients with ST-elevation myocardial infarction: a case鈥揷ontrol study

Related: THE MICROBIOME OF THROMBUS OR CLOTS IT IS CORRELATED WITH THE INTESTINAL AND ORAL MICROBIOMES This study identified microbes inside the thrombi which coincided with those present at the intestinal and oral level These would influence the formation of clots

nature.com
Comparison of thrombus, gut, and oral microbiomes in Korean patients with ST-elevation myocardial infarction: a case鈥揷ontrol study
Mw on Twitter
Mw on Twitter
IBD is an autoimmune condition, which studies have shown increases a person鈥檚 chances of Long Covid. Now doctors are seeing both de novo IBD after Covid and worsening of existing IBD. (see this thread). More research is needed. Another reason for high grade mask & ventilation.
twitter.com
Mw on Twitter