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The SARS-CoV-2 Spike protein induces long-term transcriptional perturbations of mitochondrial metabolic genes, causes cardiac fibrosis, and reduces myocardial contractile in obese mice
The SARS-CoV-2 Spike protein induces long-term transcriptional perturbations of mitochondrial metabolic genes, causes cardiac fibrosis, and reduces myocardial contractile in obese mice

New preprint of mouse study: "The SARS-CoV-2 Spike protein induces long-term transcriptional perturbations of mitochondrial metabolic genes, causes cardiac fibrosis, and reduces myocardial contractile in obese mice"

#Heart
·biorxiv.org·
The SARS-CoV-2 Spike protein induces long-term transcriptional perturbations of mitochondrial metabolic genes, causes cardiac fibrosis, and reduces myocardial contractile in obese mice
Inflammation and vascular remodeling in COVID-19 hearts
Inflammation and vascular remodeling in COVID-19 hearts
"We conclude that cardiac involvement in COVID-19 is an angiocentric macrophage-driven inflammatory process, distinct from classical anti-viral inflammatory responses, and substantially underappreciated by conventional histopathologic analysis."
#Heart
·link.springer.com·
Inflammation and vascular remodeling in COVID-19 hearts
COVID-19 Surges Linked to Spike in Heart Attacks
COVID-19 Surges Linked to Spike in Heart Attacks
“The dramatic rise in heart attacks during the pandemic has reversed what was a prior decadelong steady improvement in cardiac deaths,”
#Heart
·cedars-sinai.org·
COVID-19 Surges Linked to Spike in Heart Attacks
John Hess MD on Twitter
John Hess MD on Twitter
POST infection cardiovascular events are still occurring at significant rates. Even in the young AND with "mild" Omicron. Excess deaths in the USA have shown this for the ENTIRE pandemic (including pre-vaccine).
#Heart
·twitter.com·
John Hess MD on Twitter
Heart attack deaths jumped sharply among young US adults in 2nd year of COVID pandemic | Chattanooga Times Free Press
Heart attack deaths jumped sharply among young US adults in 2nd year of COVID pandemic | Chattanooga Times Free Press
"While other infections such as the flu are known to lead to a slightly increased risk of heart attacks, the Cedars-Sinai researchers said, they could find nothing that compared with the jump in deaths linked to the COVID-19 pandemic"
#Heart
·timesfreepress.com·
Heart attack deaths jumped sharply among young US adults in 2nd year of COVID pandemic | Chattanooga Times Free Press
Cardiac inflammation after mild COVID-19 in previously healthy people
Cardiac inflammation after mild COVID-19 in previously healthy people
"...people with mild COVID-19 showed rare signs of cardiac damage, wherein the cardiac symptoms were profound... non-ischemic cardiac inflammatory changes have been observed previously in populations comprising young athletic people following COVID-19"
#Heart
·news-medical.net·
Cardiac inflammation after mild COVID-19 in previously healthy people
COVID Attacks DNA in Heart, Unlike Flu, Study Says
COVID Attacks DNA in Heart, Unlike Flu, Study Says
"COVID-19 causes DNA damage to the heart, affecting the body in a completely different way than the flu does, according to a recent study published in Immunology"
#Heart
·webmd.com·
COVID Attacks DNA in Heart, Unlike Flu, Study Says
Dr Elisa Perego on Twitter
Dr Elisa Perego on Twitter

Twitter thread by Dr. Elisa Perego Evidence of cardiac involvement in a significant percentage of covid survivors, even with "mild" disease from Puntmann et al 2020

"cardiac MRI revealed cardiac involvement in 78 patients (78%) and ongoing myocardial inflammation in 60 patients (60%)

#Heart
·twitter.com·
Dr Elisa Perego on Twitter
Roland Baker on Twitter
Roland Baker on Twitter
(1/n) Nature: Lingering cardiac involvement in previously well people after mild COVID-19: persistent subclinical cardiovascular inflammation seems to predispose people to a poor prognosis and the development of heart failure.
#Heart
·twitter.com·
Roland Baker on Twitter
COVID-19’s Lingering Toll On The Heart
COVID-19’s Lingering Toll On The Heart
"research is revealing more about the longterm consequences of even one infection with the SARS-CoV2 virus...finding long-lasting signs of heart disorders in the majority of recovered patients in their study group–even up to nearly a year later."
#Heart
·sciencefriday.com·
COVID-19’s Lingering Toll On The Heart
Study Finds Increased Heart Disease, Stroke Risk After Surviving Even Mild Covid-19
Study Finds Increased Heart Disease, Stroke Risk After Surviving Even Mild Covid-19

After Covid: 63% higher likelihood of heart attack 72% higher likelihood of heart failure 145% higher likelihood of cardiac arrest. atrial fibrillation (71% more likely), sinus tachycardia (84%) sinus bradycardia (53%) ventricular arrhythmias (84%).

#Heart
·forbes.com·
Study Finds Increased Heart Disease, Stroke Risk After Surviving Even Mild Covid-19
Eric Topol on Twitter
Eric Topol on Twitter
"The imaging findings suggest that inflammatory cardiac involvement after COVID may be a pathophysiological commonality shared among all individuals, regardless of the expression of cardiac symptoms"
#Heart
·twitter.com·
Eric Topol on Twitter
Long-term cardiovascular outcomes of COVID-19
Long-term cardiovascular outcomes of COVID-19
“beyond the first 30 d after infection…increased risk of incident cardiovascular disease…including cerebrovascular disorders, dysrhythmias, ischemic and non-ischemic heart disease, pericarditis, myocarditis, heart failure and thromboembolic disease.“
#Heart
·nature.com·
Long-term cardiovascular outcomes of COVID-19
Prof. Christina Pagel on Twitter
Prof. Christina Pagel on Twitter
good overview of what we know - and don't know - about increased risk of heart problems after covid
#Heart
·twitter.com·
Prof. Christina Pagel on Twitter
Long-term Effects of COVID-19 in Athletes
Long-term Effects of COVID-19 in Athletes
"MRI scans of 26 collegiate athletes who had tested positive for COVID-19, 12 of whom displayed mild symptoms and 14 of whom were asymptomatic. None of the participants had required hospitalization for their COVID-19 symptoms..."
#Heart
·news-medical.net·
Long-term Effects of COVID-19 in Athletes
Heart disease after COVID: what the data say
Heart disease after COVID: what the data say

"studies suggest that the risk of cardiovascular problems, such as a heart attack or stroke, remains high even many months after a SARS-CoV-2 infection clears up." Heart disease after COVID: what the data say

#Heart
·nature.com·
Heart disease after COVID: what the data say
Dr Claire Taylor on Twitter
Dr Claire Taylor on Twitter
  • 21 players were tested before and after #COVID19 infection
  • post-Covid testing revealed abnormalities up to 2 months after infection, including raised heart rate
#Heart
·twitter.com·
Dr Claire Taylor on Twitter