SARS-CoV-2 damages cardiomyocyte mitochondria and implicates long COVID-associated cardiovascular manifestations
Covid and Heart Damage
Thread by @JackHadfield14 on Thread Reader App
“🔬New study shows SARS-CoV-2 causes direct damage to heart cell mitochondria - even months after recovery - helping potentially explain Long COVID heart symptoms like chest pain, palpitations & fatigue.
Been waiting to have time to read this paper. Let’s break it down. 🧵”
Cardiovascular outcomes in long COVID-19: a systematic review and meta-analysis
Longitudinal Characterization Of Myocardial Injury In Acute On Chronic Heart Failure In Post-acute Covid-19 Readmissions: A Retrospective Analytic Cohort Study
“SARS-CoV-2 (CoV-2) myocardial injury in patients with acute on chronic heart failure (CHF) at index hospitalization has been well-characterized. Though post-acute COVID-19 (PAC) hospitalization(s) is less investigated despite evidence that CoV-2 induced inflammatory response persists for up to 3 months after initial infection.”
SARS-CoV-2 (CoV-2) myocardial injury in patients with acute on chronic heart failure (CHF) at index hospitalization has been well-characterized. Though post-acute COVID-19 (PAC) hospitalization(s) is less investigated despite evidence that CoV-2 induced inflammatory response persists for up to 3 months after initial infection.
Coronary Implications of COVID-19 | Medical Principles and Practice | Karger Publishers
“Patients with SARS-CoV-2 infection carry an increased risk of cardiovascular disease encompassing various implications, including acute myocardial injury or infarction, myocarditis, heart failure, and arrhythmias. A growing volume of evidence correlates SARS-CoV-2 infection with myocardial injury, exposing patients to higher mortality risk. SARS-CoV-2 attacks the coronary arterial bed with various mechanisms including thrombosis/rupture of preexisting atherosclerotic plaque, de novo coronary thrombosis, endotheliitis, microvascular dysfunction, vasculitis, vasospasm, and ectasia/aneurysm formation.”
Patients with SARS-CoV-2 infection carry an increased risk of cardiovascular disease encompassing various implications, including acute myocardial injury or infarction, myocarditis, heart failure, and arrhythmias. A growing volume of evidence correlates SARS-CoV-2 infection with myocardial injury, exposing patients to higher mortality risk. SARS-CoV-2 attacks the coronary arterial bed with various mechanisms including thrombosis/rupture of preexisting atherosclerotic plaque, de novo coronary thrombosis, endotheliitis, microvascular dysfunction, vasculitis, vasospasm, and ectasia/aneurysm formation.
SARS-CoV-2 Infection Association with Atherosclerotic Plaque Progression at Coronary CT Angiography and Adverse Cardiovascular Events | Radiology
“Patients with acute SARS-CoV-2 infection are reportedly at increased risk for future cardiovascular events; the mechanism underlying this risk remains unclear.”
Patients with acute SARS-CoV-2 infection are reportedly at increased risk for future cardiovascular events; the mechanism underlying this risk remains unclear.
COVID-19 and the heart: Acute and long-term treatment options
“Management of acute and long-term COVID-19 cardiovascular syndrome is challenging and should involve a multidisciplinary team including cardiologists, intensive care specialists, infectious disease specialists, and cardiothoracic surgery specialists. A number of promising therapies were investigated during the pandemic. This chapter aims to review the best available data on acute and long-term treatment options of COVID-19 cardiovascular syndrome.”
Management of acute and long-term COVID-19 cardiovascular syndrome is challenging and should involve a multidisciplinary team including cardiologists, intensive care specialists, infectious disease specialists, and cardiothoracic surgery specialists. A number of promising therapies were investigated during the pandemic. This chapter aims to review the best available data on acute and long-term treatment options of COVID-19 cardiovascular syndrome.
Cardiac Arrhythmias and Autonomic Dysfunction Associated With COVID-19: A Scientific Statement From the American Heart Association | Circulation
Repeated Covid infections, even mild or asymptomatic, increase the risk of arrhythmias incrementally through cumulative inflammation, ANS dysfunction, and myocardial stress. Without direct studies on 2–5 infections, estimates suggest this potential rise to 8–10%(?) risk after five infections in vulnerable groups, but every C19 puts you progressively in that vulnerable group. This underscores the need to PREVENT reinfections and MONITOR cardiac health, after all mild cases.
Is COVID-19 infection linked to heart attacks?
“Taking precautionary measures is crucial to prevention. COVID is linked to many long-term health risks, and a recent study has found that it may significantly raise the risk of heart attack, stroke and death from any cause for up to three years.”
28-Year-Old Techie Suffers Heart Attack Despite Healthy Lifestyle; 80% Arterial Blockage Detected - PUNE PULSE
(It’s not rare)
“Some medical experts have speculated that in ‘rare’ cases, such incidents could be linked to post COVID complications.”
Cardiac risk in recovered Covid-19 patients evaluated by 123I-mIBG
This study investigates cardiac risk in recovered COVID-19 patients using non-invasive imaging.
Among 33 recovered COVID-19 patients with no prior heart conditions, two-thirds showed increased cardiac sympathetic activity.
Cardiovascular Implications of Long COVID, Severe COVID
SARS-CoV-2 damages cardiomyocyte mitochondria and implicates long COVID-associated cardiovascular manifestations
Long COVID May Cause Long-Term Changes in the Heart and Lungs and May Lead to Cardiac and Pulmonary Diseases
“Mount Sinai study suggests COVID-19 infection should be considered a risk factor for future cardiopulmonary conditions”
PET imaging reveals long-term heart and lung damage from COVID-19
“New PET imaging data reveal the long-term impact of COVID on heart and lungs, showing changes to these organs which are not detectable by standard medical assessments.”
History of COVID-19 doubles long-term risk of heart attack, stroke or death
Why heart attacks are striking young people - and surprising connection to a pandemic drug rule
Heart attacks are striking young Americans at “alarming levels.”
Heart attacks in people aged 18-44 years old increased by 66% between 2019 and 2023.
Child, adult COVID survivors more likely to have heart disease, symptoms, data suggest | CIDRAP
Studies from US and Poland detail COVID's cardiovascular toll: the 1st shows that infected children face significantly higher odds of conditions like high blood pressure and heart failure; the 2nd that post-infection heart symptoms are common in adults
How does Covid-19 affect your heart?
“We explain what Covid-19 does to your heart and circulatory system and how it can lead to conditions such as blood clots, heart damage, palpitations and high heart rate.”
We explain what Covid-19 does to your heart and circulatory system and how it can lead to conditions such as blood clots, heart damage, palpitations and high heart rate.
Thread by @LauraMiers on Thread Reader App
“I’m enraged by headlines like ‘Now we know how Covid attacks your heart’ 5 years after Covid WRECKED my heart at the tender age of 38. I knew exactly how Covid attacked my heart in 2020, long before my doctors, because I followed the science. All of these are from 2020-2022.”
Chronic biopsy proven post‐COVID myoendocarditis with SARS‐Cov‐2 persistence and high level of antiheart antibodies
Chronic biopsy proven post-COVID myoendocarditis with SARS-Cov-2 persistence and high level of antiheart antibodies
Chronic biopsy proven post-COVID myoendocarditis with SARS-Cov-2 persistence and high level of antiheart antibodies
928 - In Vitro Modeling of the Effects of Impaired HDL on Atherogenesis in Long COVID Syndrome
Study finds that HDL from Long COVID patients promotes key steps in early atherosclerosis.
Monocytes migrate more and take up more lipids, suggesting dysfunctional HDL may contribute to heart disease risk in Long COVID.
SPECT Perfusion Defects and Impaired Strain in Mild COVID-19: A Multimodal Imaging Study with a Female-Predominant Cohort
Even with mild symptoms during the acute phase, COVID still causes damage that gets missed with standard diagnostics.
In this study, all 15 patients had blood flow irregularities in their hearts after a COVID infection with mild symptoms.
And that's just scratching the surface.
CCL2-mediated endothelial injury drives cardiac dysfunction in long COVID
Ongoing cardiac dysfunction in Long Covid is, in part, caused by upregulation of CCL2 by inflamed endothelial cells(thrombotic vascular tissue).
2025, THE GROWING SARSCOV2 REINFECTION ERA! 🔥Let me summarise, with today’s science, how reinfections can worsen your Cardiovascular outcomes and mortgage your future health: ➡️Cumulative heart damage: Reinfections can worsen myocardial injury or increase the risk of… pic.twitter.com/neUQElrZhu— Harry Spoelstra (@HarrySpoelstra) February 15, 2025
“Let me summarise, with today’s science, how reinfections can worsen your Cardiovascular outcomes and mortgage your future health:”
Doctors Warn COVID-19 Could Be a Hidden Trigger for Heart Attacks Long After Recovery
“A new study reveals that COVID-19 fuels dangerous plaque buildup in the arteries, making heart attacks and strokes more likely. Even after recovery, the risk remains high, stressing the importance of ongoing heart health monitoring.”
A new study reveals that COVID-19 fuels dangerous plaque buildup in the arteries, making heart attacks and strokes more likely. Even after recovery, the risk remains high, stressing the importance of ongoing heart health monitoring.
Subclinical patterns of cardiac involvement by transthoracic echocardiography in individuals with mild initial COVID-19
A study of 343 people with mild COVID-19 found subtle but significant heart function changes months later.
Frontiers | Cardiovascular outcomes in long COVID-19: a systematic review and meta-analysis
“This meta-analysis showed that the cardiovascular risk burden of long-term COVID-19 is significant and spans multiple categories of cardiovascular disease (ischemic and non-ischemic heart disease, arrhythmias, etc.). Care for survivors of COVID-19 after acute attack should include attention to cardiovascular health and disease.”
This meta-analysis showed that the cardiovascular risk burden of long-term COVID-19 is significant and spans multiple categories of cardiovascular disease (ischemic and non-ischemic heart disease, arrhythmias, etc.). Care for survivors of COVID-19 after acute attack should include attention to cardiovascular health and disease.
don't get covid again whatever you do, since reinfection fin Dec and Oct, I've gone downhill badly, daily anxiety and panic, worsened pots, severe chest pain and breathlessness constantly, and crushing fatigue and leg pain, and I've found my heart has enlargement on one side.
“don't get covid again whatever you do, since reinfection in Dec and Oct, I've gone downhill badly, daily anxiety and panic, worsened pots, severe chest pain and breathlessness constantly, and crushing fatigue and leg pain, and I've found my heart has enlargement on one side.”
How the virus behind COVID-19 can harm your blood vessels and your heart
“How the virus behind COVID-19 can harm your blood vessels and your heart”
How the virus behind COVID-19 can harm your blood vessels and your heart