“SARS-CoV-2 enters Leydig cells via the ACE2 receptor, highly expressed in both mouse and human testes. Once inside, the virus hijacks the metabolic machinery for its own replication.”

“The present study demonstrated that SARS-CoV-2 significantly reduced ejaculate volume, sperm count, concentration, viability, normal morphology, and total and progressive motility. Furthermore, SARS-CoV-2 led to a reduction in circulating testosterone level, but a rise in oestrogen, prolactin, and luteinizing hormone levels. These findings were associated with a decline in testosterone/luteinizing hormone ratio. Conclusions The current study provides compelling evidence that SARS-CoV-2 may lower male fertility”