Vimentin as a contributing factor in SARS-CoV-2-induced orchitis on postmortem testicular autopsy of COVID-19 cases: A case-control study
Testicular damage as result of Covid-19. The Role of Vimentin as a Key Contributor
Transmission electron microscopy reveals the presence of SARS-CoV-2 in human spermatozoa associated with an ETosis-like response - PubMed
“Transmission electron microscopy reveals the presence of SARS-CoV-2 in human spermatozoa associated with an ETosis-like response”
Transmission electron microscopy reveals the presence of SARS-CoV-2 in human spermatozoa associated with an ETosis-like response
SARS-CoV-2 impairs male fertility by targeting semen quality and testosterone level: A systematic review and meta-analysis | PLOS ONE
“The present study demonstrated that SARS-CoV-2 significantly reduced ejaculate volume, sperm count, concentration, viability, normal morphology, and total and progressive motility. Furthermore, SARS-CoV-2 led to a reduction in circulating testosterone level, but a rise in oestrogen, prolactin, and luteinizing hormone levels. These findings were associated with a decline in testosterone/luteinizing hormone ratio. Conclusions The current study provides compelling evidence that SARS-CoV-2 may lower male fertility”
The present study demonstrated that SARS-CoV-2 significantly reduced ejaculate volume, sperm count, concentration, viability, normal morphology, and total and progressive motility. Furthermore, SARS-CoV-2 led to a reduction in circulating testosterone level, but a rise in oestrogen, prolactin, and luteinizing hormone levels. These findings were associated with a decline in testosterone/luteinizing hormone ratio.
Conclusions
The current study provides compelling evidence that SARS-CoV-2 may lower male fertility
Sperm quality and absence of SARS-CoV-2 RNA in semen after COVID-19 infection: a prospective, observational study and validation of the SpermCOVID test
"couples with a desire for pregnancy should be warned that sperm quality after COVID-19 infection can be suboptimal. The estimated recovery time is 3 months...follow-up studies are under way to confirm this and to determine if permanent damage occurred..."
Eric Feigl-Ding on Twitter
"Sperm levels—So let this sink in guys—the concentration of #COVID-infected men’s sperm is 53% LOWER than sperm of men who were not COVID infected, even 3 months later. Plus, don’t forget the bonus erectile dysfunction."
Jmv
"New study: Men infected with COVID have one third less sperm compared to uninfected men over 3 months later. Of 100 men infected and not hospitalized four had no viable sperm. Of 100 men not infected, none had this condition."
How does SARS-CoV-2 infection impact fertility in men?
"In the present review, researchers summarized potential mechanisms of SARS-CoV-2-associated reproductive system impairments and probable infertility among males."
laurie allee on Twitter
Covid, testicular damage and infertility:
Eric Topol on Twitter
How #SARSCoV2 can infect cells of the male genital tract, as demonstrated in primates
Tom Andrews on Twitter
Analysis of study thread on Twitter: "We investigated testicular alterations in deceased COVID-19-patients, the precise location of the virus, its replicative activity, and the molecules involved in the pathogenesis." 1/x
SARS-CoV-2 infects, replicates, elevates angiotensin II and activates immune cells in human testes
"Importantly, our data suggest that patients who become critically ill exhibit severe damages and may harbor the active virus in testes."
Tom Andrews on Twitter
"Scientists from Nanjing Medical University and Suzhou Hospital lead by Dr Jianqing Wang.. say that males affected by the SARS-Cov2 coronavirus which causes the Covid-19 disease will likely become infertile even if they recover"
Testicular Atrophy and Hypothalamic Pathology in COVID-19: Possibility of the Incidence of Male Infertility and HPG Axis Abnormalities
"key reports on testicular abnormalities and pathological signatures in the hypothalamus of COVID-19 patients...testicular pathology resulting from inflammation and oxidative stress might lead to infertility in a significant portion of COVID-19 survivors."