Thread by @ZdenekVrozina on Thread Reader App
“SARS-CoV-2 enters Leydig cells via the ACE2 receptor, highly expressed in both mouse and human testes. Once inside, the virus hijacks the metabolic machinery for its own replication.”
Vimentin as a contributing factor in SARS-CoV-2-induced orchitis on postmortem testicular autopsy of COVID-19 cases: A case-control study
Testicular damage as result of Covid-19. The Role of Vimentin as a Key Contributor
Eric Feigl-Ding on Twitter
"Sperm levels—So let this sink in guys—the concentration of #COVID-infected men’s sperm is 53% LOWER than sperm of men who were not COVID infected, even 3 months later. Plus, don’t forget the bonus erectile dysfunction."
Jmv
"New study: Men infected with COVID have one third less sperm compared to uninfected men over 3 months later. Of 100 men infected and not hospitalized four had no viable sperm. Of 100 men not infected, none had this condition."
laurie allee on Twitter
Covid, testicular damage and infertility:
Tom Andrews on Twitter
Analysis of study thread on Twitter: "We investigated testicular alterations in deceased COVID-19-patients, the precise location of the virus, its replicative activity, and the molecules involved in the pathogenesis." 1/x
SARS-CoV-2 infects, replicates, elevates angiotensin II and activates immune cells in human testes
"Importantly, our data suggest that patients who become critically ill exhibit severe damages and may harbor the active virus in testes."
Testicular Atrophy and Hypothalamic Pathology in COVID-19: Possibility of the Incidence of Male Infertility and HPG Axis Abnormalities
"key reports on testicular abnormalities and pathological signatures in the hypothalamus of COVID-19 patients...testicular pathology resulting from inflammation and oxidative stress might lead to infertility in a significant portion of COVID-19 survivors."