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Inborn Error of WAS Presenting with SARS-CoV-2-Related Multisystem Inflammatory Syndrome in Children

First case of a child with Wiskott-Aldrich Syndrome gene mutation presenting MIS-C after COVID-19.

Study shows inflammasome and immune dysregulation, suggesting genetic predisposition to severe inflammatory responses.

#Wiskott-Aldrich Syndrome #MIS-C #Kids

·link.springer.com·Nov 25, 2024

Inborn Error of WAS Presenting with SARS-CoV-2-Related Multisystem Inflammatory Syndrome in Children

Molecular mimicry in multisystem inflammatory syndrome in children

“Multisystem inflammatory syndrome in children (MIS-C) is a severe, post-infectious sequela of SARS-CoV-2 infection1,2, yet the pathophysiological mechanism connecting the infection to the broad inflammatory syndrome remains unknown. Here we leveraged a large set of samples from patients with MIS-C to identify a distinct set of host proteins targeted by patient autoantibodies including a particular autoreactive epitope within SNX8, a protein involved in regulating an antiviral pathway associated with MIS-C”

#MIS-C #autoimmunity #autoimmune #inflammation #SNX8 #antiviral #Viral Persistence #Post-Acute Conditions #long covid #kids

·nature.com·Sep 2, 2024

Molecular mimicry in multisystem inflammatory syndrome in children

Long-term cytokine profile in multisystem inflammatory disease among children

Italian Study: cytokines in multisystem inflammatory syndrome (MIS-C) remain elevated even 12 months post-diagnosis, suggesting long-term immune abnormalities and potential metabolic issues.

#MIS-C #cytokines #kids #Immune system #long covid #Post-Acute Conditions

·sciencedirect.com·Aug 31, 2024

Long-term cytokine profile in multisystem inflammatory disease among children

Long-term Health Outcomes After Hospital Discharge Among... : The Pediatric Infectious Disease Journal

“Approximately 20% of children with MIS-C and COVID-19 continued to have symptoms including fatigue and headache >1 year after hospital discharge.”

#MIS-C #Kids #long covid #fatigue #headaches

·journals.lww.com·Aug 21, 2024

Long-term Health Outcomes After Hospital Discharge Among... : The Pediatric Infectious Disease Journal

MIS-C has been more common and more severe than previously reported, study finds | CNN

"MIS-C after Covid-19 has been more common and more severe than previously reported, and there are significant racial disparities in cases, according to a study published Thursday in JAMA Network Open."

#Kids #MIS-C #Heart

·cnn.com·Jul 19, 2023

MIS-C has been more common and more severe than previously reported, study finds | CNN

Multisystem inflammatory syndrome in children (MIS-C) showing disseminated aspergillosis, cytomegalovirus reactivation and persistent SARS-COV-2: Case report with autopsy review

This is an autopsy of 5yo child who died of MIS-C 1 month after infection. SARS-CoV-2 was found in multiple organs by electron microscopy, PCR, or staining. They also found aspergillosis and reactivated CMV, both attributed to immunosuppressive treatment.

#Kids #MIS-C #Mortality #Immune system

·linkinghub.elsevier.com·Jul 19, 2023

Multisystem inflammatory syndrome in children (MIS-C) showing disseminated aspergillosis, cytomegalovirus reactivation and persistent SARS-COV-2: Case report with autopsy review

Case Report: Fatal Acute Liver Failure With Giant Cell Transformation in a Pediatric Patient Associated With MIS-C

#MIS-C #Liver #Kids

·frontiersin.org·Jul 19, 2023

Case Report: Fatal Acute Liver Failure With Giant Cell Transformation in a Pediatric Patient Associated With MIS-C

Prof Jeremy Nicholson: the link between Long Covid and heart disease

one in 100 kids get MIS-C / PIMS after Covid infection???

"Harvard University on paediatric Covid-19 has found about 1 percent of children are developing a related disease called multiple inflammatory syndrome in children (MIS-C)"

#MIS-C #Heart #Long Covid #Kids

·rnz.co.nz·Jul 19, 2023

Prof Jeremy Nicholson: the link between Long Covid and heart disease

MaskTogetherAmerica on Twitter

MIS-C is a COVID complication that can cause life-threatening organ inflammation. Additionally, we need to be aware that millions of children are at severe risk of severe COVID.

#MIS-C #Kids #Discussion

·twitter.com·Jul 19, 2023

MaskTogetherAmerica on Twitter

“I didn’t think it was that big of a deal, until my son’s life was plugged into the wall.” Muskegon mother recounts child's battle with MIS-C

#Kids #MIS-C

·fox17online.com·Jun 28, 2023

“I didn’t think it was that big of a deal, until my son’s life was plugged into the wall.” Muskegon mother recounts child's battle with MIS-C