This nasal spray could be a game-changer in COVID-19 prevention
Covid and Nasal Sprays for Prevention
Scientific Studies - Xlear | Sinus Care, Dental Defense, & Natural Sweeteners
XLEAR PRO-ACTIVE HEALTH UTILIZES THE BENEFITS OF XYLITOL
Intranasal Xylitol for the Treatment of COVID-19 in the Outpatient Setting: A Pilot Study
Xlear contains Xylitol which is a known antiviral. You can also get toothpaste, gum and mints that contain Xylitol.
Nasal sprays for treating COVID-19: a scientific note
"Nasal sprays for treating COVID-19: a scientific note"
David Needham on Twitter
@laurieallee thanks for highlighting my paper niclosamide, I’ll be happy to discuss with you and or anybody else who is interested in advancing this potentially preventative nasal spray and early treatment throat spray into testing
Niclosamide for Covid-19: bridging the gap
Related: "NCL has anti-inflammatory and immune regulatory effects by modulating the release of pro-inflammatory cytokines...anti-SARS-CoV-2 effect via interruption of viral life-cycle and/or induction of cytopathic effect."
Extracting Potent COVID-Fighting Pharmaceuticals for Protective Sprays
April, 2023:
"These results show a potentially more rapid route to FDA approval, bringing a new commercial opportunity that could make the nasal sprays more readily available...not just potentially for COVID-19, but also for all respiratory viruses"
Simple pH adjustment may enable a preventative Covid-19 nasal and throat spray
"Simple pH adjustment may enable a preventative Covid-19 nasal and throat spray
Higher pH makes a common metabolic inhibitor medication practical for nose and throat spray applications against COVID-19"
A randomized, double-blind, placebo-controlled phase 1 trial of inhaled and intranasal niclosamide: A broad spectrum antiviral candidate for treatment of COVID-19
"A randomized, double-blind, placebo-controlled phase 1 trial of inhaled and intranasal niclosamide: A broad spectrum antiviral candidate for treatment of COVID-19"
Inhaled Niclosamide a Potential Effective Antiviral to Treat COVID-19 | College of Pharmacy
From 2020: "Inhaled Niclosamide a Potential Effective Antiviral to Treat COVID-19"
laurie allee on Twitter
Starting thread on niclosamide:
"These researchers developed a prophylactic nasal spray and early treatment throat spray by repurposing niclosamide, a metabolic inhibitor previously used for 60 years for gut parasite infections." https://dukechronicle.com/article/2022/03/duke-university-scientist-coronavirus-covid-treatment-nasal-spray#:~:text=Niclosamide%20works%20by%20blocking%20three%20of%20the%20six,said.%20Formerly%2C%20niclosamide%20was%20FDA-approved%20in%20pill%20form.
The pH Dependence of Niclosamide Solubility, Dissolution, and Morphology: Motivation for Potentially Universal Mucin-Penetrating Nasal and Throat Sprays for COVID19, its Variants and other Viral Infections - PubMed
"prophylactic-nasal and early-treatment throat-sprays could help prevent infection and reduce viral load. Niclosamide has the potential to treat a broad-range of viral infections...as mucin-penetrating solutions that can reach underlying epithelial cells."
Study reveals how saline solution can inhibit replication of SARS-CoV-2
Study reveals how saline solution can inhibit replication of SARS-CoV-2
Can Nasal Sprays Treat or Prevent COVID-19?
Can Nasal Sprays Treat or Prevent COVID-19?
laurie allee on Twitter
Starting thread on Covixyl nasal spray for Covid prev
Covixyl Nasal Spray
Protection that Lasts up to 6 Hours Safe Covixyl® can be used daily as needed without reducing the effectiveness of the product. Because Covixyl® is not a drug, there are no side effects or adverse interactions.
The Anti-Histamine Azelastine, Identified by Computational Drug Repurposing, Inhibits Infection by Major Variants of SARS-CoV-2 in Cell Cultures and Reconstituted Human Nasal Tissue
The Anti-Histamine Azelastine, Identified by Computational Drug Repurposing, Inhibits Infection by Major Variants of SARS-CoV-2 in Cell Cultures and Reconstituted Human Nasal Tissue
Existing antihistamine drugs show effectiveness against COVID-19 virus in cell testing - UF Health
From 2020: "Among the three medications, azelastine was found to inhibit the SARS-CoV-2 virus at a dose that was smaller than the amount prescribed as a nasal spray. "
Early intervention with azelastine nasal spray may reduce viral load in SARS-CoV-2 infected patients
"Early intervention with azelastine nasal spray may reduce viral load in SARS-CoV-2 infected patients"
Hypochlorous acid as an antiseptic in the care of patients with suspected COVID-19 infection
"0.01% hypochlorous acid could act as an effective antiseptic against SARS-CoV-2, exerting a barrier on the mucosa to prevent COVID-19 infection. It can be used on the eyes, nose and mouth. We consider it necessary to assess its use in the protocol..."
Brother Jev on Twitter
Anecdote: Been using this in my nose for a while. Also a shot in the back of the throat to gargle. I’ve even used it in my eyes. That stings a little. Used it on wounds, my dogs rear end, and (of course) fruits and vegetables. It really is a miracle.
Use of Hypochlorous Acid as Prophylaxis in Health Personnel at High Risk of Infection by SARS-CoV 2 (COVID19) - Full Text View - ClinicalTrials.gov
"application of hypochlorous acid to the nasal mucosa is proposed, a broad-spectrum, fast-acting antimicrobial solution, whose safety has been proven in preclinical trials. The efficacy of HClO has been tested against enveloped and non-enveloped viruses"
Hypochlorous acid as an antiseptic in the care of patients with suspected COVID-19 infection - PubMed
"Conclusions: The 0.01% hypochlorous acid could act as an effective antiseptic against SARS-CoV-2, exerting a barrier on the mucosa to prevent COVID-19 infection. It can be used on the eyes, nose and mouth."
Preventing COVID-19 with Nasal Sprays - Holistic Primary Care
"Currently: 15 different nasal sprays under development around the worlds... hypromellose, carragelose, nitric oxide, and heparin, all of which can block viral entry via different mechanisms. Unfortunately, none of them are widely available in the US."
Stanford Medicine scientists pinpoint COVID-19 virus’s entry and exit ports inside our noses
WHERE INSIDE YOUR NOSE COVID-19 SLIPS IN ... Stanford Medicine scientists pinpoint COVID-19 virus’s entry and exit ports inside our noses
laurie allee on Twitter
“ActiMaris® NASAL Spray is a hypertonic alkaline ionised seawater solution with sea salt (1.2 %), sodium hypochlorite NaOCl (0.04 %) and hypochlorous acid HOCl (0.004 %)…create an anti-inflammatory and antimicrobial effect.”
Could a nose spray a day keep COVID away?
Research on nasal sprays as prophylaxis against Covid: "The prophylactic developed by Moscona and her colleagues, for example, is a peptide that gums up the virus’s machinery for fusing with a host cell."
Iota-Carrageenan Is a Potent Inhibitor of Influenza A Virus Infection
Mechanism of Carrageenan
Parenting Mishmash ง on Twitter
Good info thread on carrageenan nasal spray Carrageenan is only trace levels of iodine, it doesn’t last through the processing
Simple nasal wash can prevent hospitalization and deaths from COVID-19
"Simple nasal washes with mild saline water can prevent hospitalization and deaths from COVID-19, if applied twice daily following a positive diagnosis, according to research led by the US-based Augusta University."