Covid and Nasal Sprays for Prevention

Covid and Nasal Sprays for Prevention

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A Drug-Free Nasal Spray May Shield Against Respiratory Infections
A Drug-Free Nasal Spray May Shield Against Respiratory Infections

“Current nasal sprays offer limited protection against respiratory pathogens because they have a single mechanism of protection. They either neutralize pathogens or block their entry into the cells lining the nose, and they perform both tasks with limited efficacy.

‘We developed a drug-free formulation to block germs in three ways — the spray forms a gel-like matrix that enhances the capture of respiratory droplets, immobilizes the germs blocking their transport into the nasal lining, and effectively neutralizes them, preventing infection,’”

·hms.harvard.edu·
A Drug-Free Nasal Spray May Shield Against Respiratory Infections
A NEW nasal spray that trap & neutralize not only SARS-CoV-2, Influenza, RSV, Adeno & many other viruses & bacteria that are inhaled into the nose, immobilizing them until they die. The substance is 99.9% effective & contains no drugs 1/
A NEW nasal spray that trap & neutralize not only SARS-CoV-2, Influenza, RSV, Adeno & many other viruses & bacteria that are inhaled into the nose, immobilizing them until they die. The substance is 99.9% effective & contains no drugs 1/
“NEW nasal spray that trap & neutralize not only SARS-CoV-2, Influenza, RSV, Adeno & many other viruses & bacteria that are inhaled into the nose, immobilizing them until they die. The substance is >99.9% effective & contains no drugs 1/“
·x.com·
A NEW nasal spray that trap & neutralize not only SARS-CoV-2, Influenza, RSV, Adeno & many other viruses & bacteria that are inhaled into the nose, immobilizing them until they die. The substance is 99.9% effective & contains no drugs 1/
Preclinical studies suggest a drug-free nasal spray could ward off respiratory infections
Preclinical studies suggest a drug-free nasal spray could ward off respiratory infections

“Preclinical studies suggest a drug-free nasal spray could ward off respiratory infections Researchers from the Brigham detail how the spray they created may offer broad-spectrum protection from respiratory infections by COVID-19, influenza, everyday cold viruses, and pneumonia-causing bacteria”

·eurekalert.org·
Preclinical studies suggest a drug-free nasal spray could ward off respiratory infections
🔥 New, promising data on Profi Nasal Spray (aka PCANS) as prophylaxis for respiratory viruses:
🔥 New, promising data on Profi Nasal Spray (aka PCANS) as prophylaxis for respiratory viruses:

New, promising data on Profi Nasal Spray (aka PCANS) as prophylaxis for respiratory viruses:

“The researchers developed the formulation and studied its ability to capture respiratory droplets in a 3D-printed replica of a human nose. They showed that when sprayed in the nasal cavity replica, PCANS captured twice as many droplets as mucus alone.

·x.com·
🔥 New, promising data on Profi Nasal Spray (aka PCANS) as prophylaxis for respiratory viruses:
Washing Illness Away: A Systematic Review of the Impact of Nasal Irrigation and Spray on COVID‐19 - Gandhi - The Laryngoscope - Wiley Online Library
Washing Illness Away: A Systematic Review of the Impact of Nasal Irrigation and Spray on COVID‐19 - Gandhi - The Laryngoscope - Wiley Online Library
“Nasal irrigation is a common treatment for sinonasal disorders; however, it is unknown if it can reduce SARS-CoV-2 nasopharyngeal viral load (NVL). This systematic review investigated the efficacy of nasal irrigation with saline, povidone iodine (PVP-I), and intranasal corticosteroids (INCS) at reducing SARS-CoV-2 NVL and transmissibility.
·onlinelibrary.wiley.com·
Washing Illness Away: A Systematic Review of the Impact of Nasal Irrigation and Spray on COVID‐19 - Gandhi - The Laryngoscope - Wiley Online Library
Saline nasal irrigation and gargling in COVID-19: a multidisciplinary review of effects on viral load, mucosal dynamics, and patient outcomes
Saline nasal irrigation and gargling in COVID-19: a multidisciplinary review of effects on viral load, mucosal dynamics, and patient outcomes
“While it is acknowledged that a short 30-s contact of saline with the SARS-CoV-2 virus does not exhibit direct virucidal activity (131), this narrative review on SI revealed that nasal SI performed repeatedly for 1 day may lead to a significant reduction in nasopharyngeal virus load, while a repeated application for 7–10 days leads to faster viral clearance. Overall, patients with positive swab tests experienced substantial viral load reduction, became PCR-negative faster, and had milder symptoms than untreated patients.”
·ncbi.nlm.nih.gov·
Saline nasal irrigation and gargling in COVID-19: a multidisciplinary review of effects on viral load, mucosal dynamics, and patient outcomes
Astodrimer sodium nasal spray forms a barrier to SARS-CoV-2 in vitro and preserves normal mucociliary function in human nasal epithelium
Astodrimer sodium nasal spray forms a barrier to SARS-CoV-2 in vitro and preserves normal mucociliary function in human nasal epithelium
Study in Australia on 14 human donors: Astodrimer sodium nasal spray reduced SARS-CoV-2 infectivity by 96.6% and preserved normal mucociliary function.
·nature.com·
Astodrimer sodium nasal spray forms a barrier to SARS-CoV-2 in vitro and preserves normal mucociliary function in human nasal epithelium
A randomized, double-blind, placebo-controlled phase 1 trial of inhaled and intranasal niclosamide: A broad spectrum antiviral candidate for treatment of COVID-19
A randomized, double-blind, placebo-controlled phase 1 trial of inhaled and intranasal niclosamide: A broad spectrum antiviral candidate for treatment of COVID-19
"A randomized, double-blind, placebo-controlled phase 1 trial of inhaled and intranasal niclosamide: A broad spectrum antiviral candidate for treatment of COVID-19"
·thelancet.com·
A randomized, double-blind, placebo-controlled phase 1 trial of inhaled and intranasal niclosamide: A broad spectrum antiviral candidate for treatment of COVID-19
laurie allee on Twitter
laurie allee on Twitter

Starting thread on niclosamide:

"These researchers developed a prophylactic nasal spray and early treatment throat spray by repurposing niclosamide, a metabolic inhibitor previously used for 60 years for gut parasite infections." https://dukechronicle.com/article/2022/03/duke-university-scientist-coronavirus-covid-treatment-nasal-spray#:~:text=Niclosamide%20works%20by%20blocking%20three%20of%20the%20six,said.%20Formerly%2C%20niclosamide%20was%20FDA-approved%20in%20pill%20form.

·twitter.com·
laurie allee on Twitter
The pH Dependence of Niclosamide Solubility, Dissolution, and Morphology: Motivation for Potentially Universal Mucin-Penetrating Nasal and Throat Sprays for COVID19, its Variants and other Viral Infections - PubMed
The pH Dependence of Niclosamide Solubility, Dissolution, and Morphology: Motivation for Potentially Universal Mucin-Penetrating Nasal and Throat Sprays for COVID19, its Variants and other Viral Infections - PubMed
"prophylactic-nasal and early-treatment throat-sprays could help prevent infection and reduce viral load. Niclosamide has the potential to treat a broad-range of viral infections...as mucin-penetrating solutions that can reach underlying epithelial cells."
·pubmed.ncbi.nlm.nih.gov·
The pH Dependence of Niclosamide Solubility, Dissolution, and Morphology: Motivation for Potentially Universal Mucin-Penetrating Nasal and Throat Sprays for COVID19, its Variants and other Viral Infections - PubMed
Covixyl Nasal Spray
Covixyl Nasal Spray

Protection that Lasts up to 6 Hours Safe Covixyl® can be used daily as needed without reducing the effectiveness of the product. Because Covixyl® is not a drug, there are no side effects or adverse interactions.

·covixyl.com·
Covixyl Nasal Spray
The Anti-Histamine Azelastine, Identified by Computational Drug Repurposing, Inhibits Infection by Major Variants of SARS-CoV-2 in Cell Cultures and Reconstituted Human Nasal Tissue
The Anti-Histamine Azelastine, Identified by Computational Drug Repurposing, Inhibits Infection by Major Variants of SARS-CoV-2 in Cell Cultures and Reconstituted Human Nasal Tissue
The Anti-Histamine Azelastine, Identified by Computational Drug Repurposing, Inhibits Infection by Major Variants of SARS-CoV-2 in Cell Cultures and Reconstituted Human Nasal Tissue
·t.co·
The Anti-Histamine Azelastine, Identified by Computational Drug Repurposing, Inhibits Infection by Major Variants of SARS-CoV-2 in Cell Cultures and Reconstituted Human Nasal Tissue
Hypochlorous acid as an antiseptic in the care of patients with suspected COVID-19 infection
Hypochlorous acid as an antiseptic in the care of patients with suspected COVID-19 infection
"0.01% hypochlorous acid could act as an effective antiseptic against SARS-CoV-2, exerting a barrier on the mucosa to prevent COVID-19 infection. It can be used on the eyes, nose and mouth. We consider it necessary to assess its use in the protocol..."
·ncbi.nlm.nih.gov·
Hypochlorous acid as an antiseptic in the care of patients with suspected COVID-19 infection