âQuick đ§”on the current state of Iota-carrageenan nasal sprays: Efficacy, safety, Betadine shortages, buying options for US & Can. markets.
I-C sprays are the only option on the market that have a real-world randomized, double-blind, placebo-controlled study backing them up. 1/14â
âCurrent nasal sprays offer limited protection against respiratory pathogens because they have a single mechanism of protection. They either neutralize pathogens or block their entry into the cells lining the nose, and they perform both tasks with limited efficacy.
âWe developed a drug-free formulation to block germs in three ways â the spray forms a gel-like matrix that enhances the capture of respiratory droplets, immobilizes the germs blocking their transport into the nasal lining, and effectively neutralizes them, preventing infection,ââ
Nose Sprays: A Last Line of Defense in a World Hellbent on Giving You Covid Here's what we know.
âPreclinical studies suggest a drug-free nasal spray could ward off respiratory infections Researchers from the Brigham detail how the spray they created may offer broad-spectrum protection from respiratory infections by COVID-19, influenza, everyday cold viruses, and pneumonia-causing bacteriaâ
New, promising data on Profi Nasal Spray (aka PCANS) as prophylaxis for respiratory viruses:
âThe researchers developed the formulation and studied its ability to capture respiratory droplets in a 3D-printed replica of a human nose. They showed that when sprayed in the nasal cavity replica, PCANS captured twice as many droplets as mucus alone.
@laurieallee thanks for highlighting my paper niclosamide, Iâll be happy to discuss with you and or anybody else who is interested in advancing this potentially preventative nasal spray and early treatment throat spray into testing
Related: "NCL has anti-inflammatory and immune regulatory effects by modulating the release of pro-inflammatory cytokines...anti-SARS-CoV-2 effect via interruption of viral life-cycle and/or induction of cytopathic effect."
April, 2023:
"These results show a potentially more rapid route to FDA approval, bringing a new commercial opportunity that could make the nasal sprays more readily available...not just potentially for COVID-19, but also for all respiratory viruses"
"Simple pH adjustment may enable a preventative Covid-19 nasal and throat spray
Higher pH makes a common metabolic inhibitor medication practical for nose and throat spray applications against COVID-19"
From 2020: "Inhaled Niclosamide a Potential Effective Antiviral to Treat COVID-19"
Starting thread on niclosamide:
"These researchers developed a prophylactic nasal spray and early treatment throat spray by repurposing niclosamide, a metabolic inhibitor previously used for 60 years for gut parasite infections." https://dukechronicle.com/article/2022/03/duke-university-scientist-coronavirus-covid-treatment-nasal-spray#:~:text=Niclosamide%20works%20by%20blocking%20three%20of%20the%20six,said.%20Formerly%2C%20niclosamide%20was%20FDA-approved%20in%20pill%20form.
Protection that Lasts up to 6 Hours Safe CovixylÂź can be used daily as needed without reducing the effectiveness of the product. Because CovixylÂź is not a drug, there are no side effects or adverse interactions.
From 2020: "Among the three medications, azelastine was found to inhibit the SARS-CoV-2 virus at a dose that was smaller than the amount prescribed as a nasal spray. "
