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The bullwhip effect, T-cell telomeres, and SARS-CoV-2
Covid and Telomeres
I WON’T vote 4 Harris/Buttigieg/AOC in 2024 on Twitter
Discussion A 30 pack year history of smoking reduces telomere length by 169 bp’s. A single SARS2 infection reduces telomere length by almost 7000 bp’s.
(No, smoking is —not— safe people. Tobacco is also a hazard.)
Citations:
I WON’T vote 4 Harris/Buttigieg/AOC in 2024 on Twitter
Discussion 1 SARS2 exposure (infection) demolishes > 50% of our telomere length. Multiple exposure will result in cumulative & severe harm, not limited to primary T cell immunodeficiencies, dementias, cancer, renal failure, pulmonary fibrosis
Paul Maidowski on Twitter
Discussion There are published sources to confirm AJ's claim. SARS-CoV-2 associated acceleration of biological age and telomere shortening are irreversible processes, as far as I'm aware.
Accelerated biological aging in COVID-19 patients
"We also find the increasing acceleration of epigenetic aging & telomere attrition in the sequential blood samples from healthy individuals and infected patients developing non-severe & severe COVID-19."
Evidence for Biological Age Acceleration and Telomere Shortening in COVID-19 Survivors
Evidence for biological age acceleration & telomere shortening after Covid19: "In light of these observations, we hypothesize that some epigenetic alterations are associated with the post-COVID-19 condition, particularly in younger patients (< 60 years)."