Covid and Vascular System, Endothelium, Blood Clots
“NEW PREPRINT! Another study about ABNORMAL BLOOD CLOTTING related to SARS-CoV-2, but unlike the others I've covered, this isn't related to the spike protein.
Turns out that Mpro, a viral protease [pro-tee-ace], can START the cascade.
a thread written for everyone:
Here's the takeaway: The Main protease (Mpro) of SARS-CoV-2—an enzyme that cuts up viral polyproteins—can also cleave a few host coagulation factors in a way that ACTIVATES them and BEGINS the blood clot cascade.”
Great analysis thread:
“SIGNIFICANT NEW STUDY PUBLISHED TODAY IN NATURE!
Fibrin ‘binds to the SARS-CoV-2 spike protein,’ forming clots that ‘drive systemic thromboinflammation and neuropathology,’ and it happens ‘independently of active infection.’
Simplified breakdown of the paper below!
"The COVID-19 thrombus has unique and distinct characteristics."
Thrombosis in acute and #LongCovid
“COVID-19, caused by the SARS-CoV-2 virus is an acquired thrombophila with a high incidence of thrombosis.
“Thrombosis…can involve most organs and organ systems.”
Thread by @DickZoutman on Thread Reader App
No Amount of Hand-Washing Can Make COVID-19 a Seasonal Virus
"The selection of words modulates the message...terms such as “seasonal”, “like a cold”, and “like the flu” can be selected by writers to...lull the reader into a false sense of security... COVID-19 is not primarily a respiratory infection. This virus can cause a systemic disease with far-reaching effects on the body, particularly blood vessels. Once SARS-CoV-2 enters the body, the virus can affect the ...blood vessels, causing inflammation and damage.
It is NOT a pneumonia or pneumonitis It is an immunothrombotic vasculopathy (inflammatory clotting disease)
Latest paper from Dr Robin Kerr & me: #LongCovid is primarily a Spike protein Induced Thrombotic Vasculitis https://researchsquare.com/article/rs-2939263/v1 Here we proposed that long covid is primarily a spike protein-induced thrombotic vasculitis, & we use Robin as a supporting case study 🧵 #TeamClots
Related: "Blood thinners and COVID: The findings guiding patient care"
From 2021: "Blood clot risk from coronavirus infection outweighs risk from vaccine: study
This is the largest study to date, covering almost 30 million people."
Known since 2020: "CHOP Researchers Find Elevated Biomarker Related to Blood Vessel Damage in All Children with SARS-CoV-2 Regardless of Disease Severity"
Not only does a mild Covid infection cause vascular degeneration and arterial stiffness, but it also appears that both of these conditions are degenerative.
"The longer the period from COVID-19 infection the worse the vascular impairment...."
From 2022--largely ignored/unknown by clinicians: “There are also manifestations of people having an increased risk of blood clots during and after COVID-19..."