Deep vein thrombosis and pulmonary embolism in pediatric COVID-19
"Furthermore, the virus itself provokes a direct endothelial injury activating the coagulation cascade. The vascular endothelium is a key target-organ of SARS-Cov-2"
Covid and Vascular System, Endothelium, Blood Clots
Hormone Therapy in the Era of the COVID-19 Pandemic: A Review
"...the benefits of menopausal hormone therapy outweigh the risks even in the situation of COVID-19 pandemic and vaccination. Caution is needed in relation to the risk of thrombosis"
SARS Covid-19 as an immunothrombotic disease and the potential benefits of a new estrogen-free contraceptive containing drospirenone.
"As Covid-19 is considered an immunothrombotic disease, the potential benefits of estrogen-free contraceptives like drospirenone are discussed. Adding estrogens in contraception may rise the cardiovascular risk in Covid-19 and Long Covid patients."
Rth2
"Coagulopathy has been recognized as a complication of COVID-19, and the incidence of thrombotic events may be as high as 31% among critically ill patients with the disease.80, 81 There is a concern that hormone therapy may compound this thrombotic risk."
Pmc7301099
"...exogenous estrogens may increase coagulating factors and the risk of thromboembolic events with a potential consequent increase in mortality."
Estrogen and COVID-19: Birth Control Can Increase Blood Clot Risk
Estrogen and COVID-19: How Pregnancy, Birth Control Can Increase Risk of Blood Clots
laurie allee on Twitter
Starting thread on estrogen / birth control pills / hormone replacement and blood clot risk from Covid
Eric Topol on Twitter
Analysis thread on Twitter: The persistent excess of arterial and venous blood clots after Covid at 1 year compared with controls https://ahajournals.org/doi/10.1161/CIRCULATIONAHA.122.060785 @CircAHA by @jonathanasterne and colleagues
Circulationaha
“Association of COVID-19 With Major Arterial and Venous Thrombotic Diseases: A Population-Wide Cohort Study of 48 Million Adults in England and Wales”
The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells
The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells
Proteomics of fibrin amyloid microclots in long COVID/post-acute sequelae of COVID-19 (PASC) shows many entrapped pro-inflammatory molecules that may also contribute to a failed fibrinolytic system - Cardiovascular Diabetology
More evidence that LongCOVID symptoms are due to widespread endothelial damage and a failed fibrinolytic system. We again found numerous entrapped inflammatory molecules; and this time also antibodies in microclots
Blood clot risk remains elevated nearly a year after COVID-19
"Blood clot risk remains elevated nearly a year after COVID-19"
laurie allee on Twitter
Starting thread on Covid related aneurysms
Ruptured cerebral aneurysms in COVID-19 patients: A review of literature with case examples - PubMed
"...strongly implicated to cause degenerative vascular changes that may predispose patients to cerebral aneurysm formation, change in size or morphology, and resultant aneurysm rupture."
Rth2
Biomarker derived risk scores predict venous thromboembolism and major bleeding among patients with COVID-19
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Can COVID-19 increase the risk of developing deep vein thrombosis?
"One study analyzed the sequelae of more than one million people affected in Sweden and noted that the risk of suffering from DVT increases by five times."
Management of venous thromboembolism in COVID-19 - The Pharmaceutical Journal
Related: "Management of venous thromboembolism in COVID-19"
A study reports the first case of an upper extremity deep vein thrombosis (DVT) recurrence due to COVID-19 infection
"A study reports the first case of an upper extremity deep vein thrombosis (DVT) recurrence due to COVID-19 infection..."
What Is a DVT?
"COVID-19 increases people's risk of dangerous blood clots and bleeding for months after infection, researchers say.
The new findings suggest that COVID-19 is an independent risk factor for deep vein thrombosis, pulmonary embolism and bleeding."
The Link Between COVID-19 and Deep Vein Thrombosis
The Link Between COVID-19 and Deep Vein Thrombosis
laurie allee on Twitter
Starting thread on Covid and deep vein thrombosis.
Many COVID patients aged under 20 died within week from onset of symptoms: Japan study
From 2022 It is not just adults that die from COVID-19. A recent study in Japan looked at 41 children under the age of 20 who were infected and died between January and August of this year, 73% within a week after symptom onset
Neurovascular injury with complement activation and inflammation in COVID-19
A study that performed autopsies on the brains of COVID-19 patients who died shortly after infection found all patients had multifocal vascular damage in the brain which was accompanied by widespread endothelial cell activation
COVID-19 takes serious toll on heart health—a full year after recovery
Infected patients develop blood clots, heart inflammation, arrhythmias, and heart failure among others (
Jeff Gilchrist on Twitter
Detailed analysis thread on Twitter: COVID-19: Increased risk of dying from infection and sudden death
This a long thread looks at several studies on death and neurovascular injury along with a whole bunch of sudden death examples of relatively young and healthy people found by @MeetJess . 🧵1/
Persistent clotting protein pathology in Long COVID/Post-Acute Sequelae of COVID-19 (PASC) is accompanied by increased levels of antiplasmin - Cardiovascular Diabetology
"Persistent clotting protein pathology in Long COVID/Post-Acute Sequelae of COVID-19 (PASC) is accompanied by increased levels of antiplasmin"
Virtually all children infected with COVID-19 show signs of blood vessel damage, study shows
From 2020: "Virtually all children infected with COVID-19 show signs of blood vessel damage, study shows"
Expert’s warning as nearly one in four Covid patients show signs of blood clotting a year later
"Up to a quarter of patients discharged from hospital after Covid-19 treatment are still showing “unusual” blood clotting activity up to one year later."
COVID-19 and the Brain
From 2020: "Vascular events such as strokes have been reported in COVID-19 patients. It is thought that SARS-CoV-2 causes a thickening of the blood, which leads to blood clots"
Dr Claire Taylor on Twitter
1/A reminder that #LongCovid patients have microclots. We are sending children to school with no mitigations and a 5% chance of a disease that damages you blood vessels.🩸 ALL 80 patients tested in this paper had moderate microclots. Green is microclots.