Covid General Articles, Discussions, Videos

Covid General Articles, Discussions, Videos

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#antibodies
Potent and broadly neutralizing antibodies against sarbecoviruses elicited by single ancestral SARS-CoV-2 infection
Potent and broadly neutralizing antibodies against sarbecoviruses elicited by single ancestral SARS-CoV-2 infection

Scientists in China found a potent antibody, CYFN1006-1, from early COVID-19 survivors.

It neutralizes all major variants and even SARS-CoV.

In hamsters, it cut viral loads, showing promise for future treatments

#antibodies#China#CYFN1006-1#treatment
·nature.com·
Potent and broadly neutralizing antibodies against sarbecoviruses elicited by single ancestral SARS-CoV-2 infection
High Frequency of Prior Severe Acute Respiratory Syndrome Coronavirus 2 Infection by Sensitive Nucleocapsid Assays | The Journal of Infectious Diseases | Oxford Academic
High Frequency of Prior Severe Acute Respiratory Syndrome Coronavirus 2 Infection by Sensitive Nucleocapsid Assays | The Journal of Infectious Diseases | Oxford Academic
“In this study, we show that the Simoa serology assay and T-cell intracellular cytokine staining assay are more sensitive than the clinical Elecsys assay for detection of nucleocapsid-specific immune responses. These data suggest that the prevalence of prior SARS-CoV-2 infection in the population may be higher than currently appreciated.”
In this study, we show that the Simoa serology assay and T-cell intracellular cytokine staining assay are more sensitive than the clinical Elecsys assay for detection of nucleocapsid-specific immune responses. These data suggest that the prevalence of prior SARS-CoV-2 infection in the population may be higher than currently appreciated.
#nucleocapside#antibodies#antibody test#Simoa#Covid Statistics
·academic.oup.com·
High Frequency of Prior Severe Acute Respiratory Syndrome Coronavirus 2 Infection by Sensitive Nucleocapsid Assays | The Journal of Infectious Diseases | Oxford Academic
Antigenic imprinting dominates humoral responses to new variants of SARS-CoV-2 in a hamster model of COVID-19
Antigenic imprinting dominates humoral responses to new variants of SARS-CoV-2 in a hamster model of COVID-19

Study at KU Leuven on hamsters finds that immunity from XBB.1.5 COVID-19 vaccine favors the original strain, limiting antibody response to newer variants like JN.1.

Highlights the challenge of updating vaccines for evolving SARS-CoV-2.

#vaccine#antibodies#immune system#antigenic imprinting#MRNA
·biorxiv.org·
Antigenic imprinting dominates humoral responses to new variants of SARS-CoV-2 in a hamster model of COVID-19
Why protective antibodies fade after COVID-19 vaccines
Why protective antibodies fade after COVID-19 vaccines

While effective at preventing severe COVID-19, the protection you get from mRNA vaccines can fade within months.

Long-lasting immune cells that fight SARS-CoV-2 aren't usually found in mRNA-vaccinated people, unlike the immune cells for tetanus and flu.

#vaccine#MRNA#antibodies
·nih.gov·
Why protective antibodies fade after COVID-19 vaccines
UT researchers say they found an antibody that protects against all COVID-19 variants
UT researchers say they found an antibody that protects against all COVID-19 variants
A team of researchers, led by folks at the University of Texas at Austin, believe they’ve found an antibody that protects against all COVID-19 variants.
A team of researchers, led by folks at the University of Texas at Austin, believe they’ve found an antibody that protects against all COVID-19 variants.
#antibodies#variants#treatment#VIdeo
·kxan.com·
UT researchers say they found an antibody that protects against all COVID-19 variants