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SARS-CoV-2 variants induce increased inflammatory gene expression but reduced interferon responses and heme synthesis as compared with wild type strains
SARS-CoV-2 variants induce increased inflammatory gene expression but reduced interferon responses and heme synthesis as compared with wild type strains
This study provides some insights into why some people remain asymptomatic when infected with SARS-CoV-2, particularly the newer variants
·nature.com·
SARS-CoV-2 variants induce increased inflammatory gene expression but reduced interferon responses and heme synthesis as compared with wild type strains
She’s had covid “20-25” times since covid started—and that’s with confirmed positive tests at urgent care or the hospital because she has terrible symptoms with covid each and every time she’s had it. The doctor said “maybe your body’s not making the antibodies to fight it.”😭
She’s had covid “20-25” times since covid started—and that’s with confirmed positive tests at urgent care or the hospital because she has terrible symptoms with covid each and every time she’s had it. The doctor said “maybe your body’s not making the antibodies to fight it.”😭
“She’s had covid ‘20-25’ times since covid started—and that’s with confirmed positive tests at urgent care or the hospital because she has terrible symptoms with covid each and every time she’s had it. The doctor said ‘maybe your body’s not making the antibodies to fight it.’”😭
·x.com·
She’s had covid “20-25” times since covid started—and that’s with confirmed positive tests at urgent care or the hospital because she has terrible symptoms with covid each and every time she’s had it. The doctor said “maybe your body’s not making the antibodies to fight it.”😭
Antigenic imprinting dominates humoral responses to new variants of SARS-CoV-2 in a hamster model of COVID-19
Antigenic imprinting dominates humoral responses to new variants of SARS-CoV-2 in a hamster model of COVID-19

Study at KU Leuven on hamsters finds that immunity from XBB.1.5 COVID-19 vaccine favors the original strain, limiting antibody response to newer variants like JN.1.

Highlights the challenge of updating vaccines for evolving SARS-CoV-2.

·biorxiv.org·
Antigenic imprinting dominates humoral responses to new variants of SARS-CoV-2 in a hamster model of COVID-19
COVID-19 Causes Ciliary Dysfunction as Demonstrated by Human Intranasal Micro-Optical Coherence Tomography Imaging
COVID-19 Causes Ciliary Dysfunction as Demonstrated by Human Intranasal Micro-Optical Coherence Tomography Imaging

COVID increases the risk of secondary infections by impairing mucosal clearance.

"Our results demonstrate profound ciliary loss in the nasal epithelium even in subjects with mild disease and shed light on mechanisms that... probably predispose patients to secondary infections."

·pmc.ncbi.nlm.nih.gov·
COVID-19 Causes Ciliary Dysfunction as Demonstrated by Human Intranasal Micro-Optical Coherence Tomography Imaging
COVID-19 Causes Ciliary Dysfunction as Demonstrated by Human Intranasal Micro-Optical Coherence Tomography Imaging
COVID-19 Causes Ciliary Dysfunction as Demonstrated by Human Intranasal Micro-Optical Coherence Tomography Imaging

COVID increases the risk of secondary infections by impairing mucosal clearance.

"Our results demonstrate profound ciliary loss in the nasal epithelium even in subjects with mild disease and shed light on mechanisms that... probably predispose patients to secondary infections."

·pmc.ncbi.nlm.nih.gov·
COVID-19 Causes Ciliary Dysfunction as Demonstrated by Human Intranasal Micro-Optical Coherence Tomography Imaging
🧵 I think I have a very unique & valuable perspective when it comes to SARS-CoV-2. I've spent the 1st three years of the pandemic in one of the the busiest hospital based chemistry/bloodgas labs in the US & the last 20 months as a generalist in a medium sized hospital. 1/
🧵 I think I have a very unique & valuable perspective when it comes to SARS-CoV-2. I've spent the 1st three years of the pandemic in one of the the busiest hospital based chemistry/bloodgas labs in the US & the last 20 months as a generalist in a medium sized hospital. 1/
“🧵 I think I have a very unique & valuable perspective when it comes to SARS-CoV-2. I've spent the 1st three years of the pandemic in one of the the busiest hospital based chemistry/bloodgas labs in the US & the last 20 months as a generalist in a medium sized hospital. 1/“
·x.com·
🧵 I think I have a very unique & valuable perspective when it comes to SARS-CoV-2. I've spent the 1st three years of the pandemic in one of the the busiest hospital based chemistry/bloodgas labs in the US & the last 20 months as a generalist in a medium sized hospital. 1/
‘General Hospital’ Icon Emma Samms Talks Latest Return to the Show Amid Her Battle With Long COVID (EXCLUSIVE)
‘General Hospital’ Icon Emma Samms Talks Latest Return to the Show Amid Her Battle With Long COVID (EXCLUSIVE)

“I’ve been like this now for four and a half years nearly, and it’s baffling to not just the people who have it, but it’s baffling to the doctors,” she says. “They are some very smart people who are investigating and studying it and doing research, but all they keep finding is more and more damage that COVID has done to people’s bodies.

“I got some really good scans done and they found that at some point I had had myocarditis, which has scarred my heart,” Samms continues. “The consequences of COVID — I think we still have only just scratched the surface, and it’s terrifying to me that people think we are no longer in a pandemic. Because they so desperately want it to not affect them, they sort of pretend that it is has gone, and it so hasn’t.”

·variety.com·
‘General Hospital’ Icon Emma Samms Talks Latest Return to the Show Amid Her Battle With Long COVID (EXCLUSIVE)
As COVID Surges, the High Price of Viral Denial | The Tyee
As COVID Surges, the High Price of Viral Denial | The Tyee

“Repeated studies show in the bluntest terms that the initial acute infection is only the tip of the iceberg. Even a mild bout of COVID can leave a legacy of blood clots, heart failure, diabetes, decreased brain function (see sidebar), long COVID (now affecting 400 million people worldwide) and immune damage that increasingly makes people more vulnerable to a plethora of infectious diseases and possibly cancers.

These problems can erupt three years after an infection”

·thetyee.ca·
As COVID Surges, the High Price of Viral Denial | The Tyee
I tested + for COVID again today. Same infection since March. 179 days. My insurance won't cover more Paxlovid to treat or Pemgarda to prevent (likely also treat). Still trying for mAbs, but FDA has threatened to pull Pemgarda. Afraid I'll lose my chance to clear this infection.
I tested + for COVID again today. Same infection since March. 179 days. My insurance won't cover more Paxlovid to treat or Pemgarda to prevent (likely also treat). Still trying for mAbs, but FDA has threatened to pull Pemgarda. Afraid I'll lose my chance to clear this infection.
·x.com·
I tested + for COVID again today. Same infection since March. 179 days. My insurance won't cover more Paxlovid to treat or Pemgarda to prevent (likely also treat). Still trying for mAbs, but FDA has threatened to pull Pemgarda. Afraid I'll lose my chance to clear this infection.
“Debilitating a Generation”: Expert Warns That Long COVID May Eventually Affect Most Americans
“Debilitating a Generation”: Expert Warns That Long COVID May Eventually Affect Most Americans

“Think you’ve grasped the full extent of COVID’s ongoing impact? Think again. As Americans shrug off vaccines and forget indoor air quality, the virus stealthily continues its destructive path. This was pretty much inevitable without new guidance urging a change in strategy and nobody telling us the full truth.

The danger is clear and present: COVID isn’t merely a respiratory illness; it’s a multi-dimensional threat impacting brain function, attacking almost all of the body’s organs, producing elevated risks of all kinds, and weakening our ability to fight off other diseases. Reinfections are thought to produce cumulative risks, and Long COVID is on the rise. Unfortunately, Long COVID is now being considered a long-term chronic illness — something many people will never fully recover from.”

“Debilitating a Generation”: Expert Warns That Long COVID May Eventually Affect Most Americans
·ineteconomics.org·
“Debilitating a Generation”: Expert Warns That Long COVID May Eventually Affect Most Americans