New protocol from Japan enables high-affinity monoclonal antibody production from single B cells in 6 days.
Cost-effective and works across antibody types, including for SARS-CoV-2 spike protein.
“It doesn't get much more macho or conservative than the Marines. Nice of them to demonstrate even cotton masks reduce disease transmission in November 2024.
They require masks in Phase 1, because they have new recruits gathered together.”
“All personnel must wear a mask while indoors at the Branch Medical Clinic and the Branch Dental Clinic.
All Recruits must wear masks during Phase 1 of Recruit Training.”
“Report suggests potential excess mortality in the general population of up to 3% for the US by 2033 and 2.5% in the UK, the longest period of elevated peacetime excess mortality in the US Key driver of excess mortality is the lingering impact of COVID-19; both as a direct cause of death, and as a contributor to cardiovascular mortality”
Chinese researchers:
GZNL-P36 is a promising drug candidate for COVID-19 targeting a conserved viral enzyme, showing broad antiviral and anti-inflammatory effects.
Mouse trials: it reduces viral load, inflammation, and lung damage
November 22, 2024 “On Wednesday, the CDC warned it expects to see an increase in Covid and RSV levels in the coming weeks as large gatherings, travel and more time indoors allow disease to spread more easily person-to-person. The CDC recommends opening windows and doors for ventilation, wearing masks in crowded areas, practicing regular handwashing and being up-to-date on Covid and flu vaccinations to avoid getting sick. “
Nov 22, 2024: “Respiratory viruses continue to spread in Arizona. The Arizona Department of Health Services reported more than 1,000 cases of influenza last week and more than 2,100 cases of COVID-19.
Researchers at The University of Hong Kong developed TMP1, an oral drug blocking coronavirus entry and replication.
Tested in mice and hamsters, it was effective against SARS-CoV-2 variants and drug-resistant strains.
“I politely asked her to wear it and told her I was immunocompromised. She rolled her eyes, held the mask in front of her face without actually putting it on. She leaned across me to hit the button, even though there was another set of buttons on the opposite side of the elevator. This felt like a deliberate attempt to violate my personal space and ensure I knew just how unhappy she was that I asked her to mask. As time went on and more people bought into the comfortable lie that COVID was over, it became harder to access safe medical care. Fewer and fewer staff were complying with mandates; eventually mandates were dropped altogether in favour of “mask-friendly” policies.”
“Intranasal protein vaccine with MF59-like adjuvant protects against SARS-CoV-2, including XBB variants.
In mice, it boosts mucosal immunity with durable neutralizing antibodies.”
“We analyzed the deaths of United States Politicians during the #COVIDPandemic & found some interesting statistics.
From 2020-2024 (into November) at least 466 active (or recently active) politicians, judges, & the like passed away. “
COVID-19 hitches a ride on mucus to spread deep into lungs, live imaging shows.
Investigators observed that the movement of mucus can spread the COVID-19 virus inside the respiratory tract, where it later forms aerosols that infect other people.
PICOBOO randomized trial, evaluating second boosters after mRNA priming. 1) novavax is more durable 2) mRNA vaccines have higher antibody responses 3) novavax has fewer side effects
Pfizer antibody levels drop around 40% between 1 month to 3 months post vax. Moderna is less, w/ a 14% drop in younger adults, 26% decline in older adults. Novavax had only a 3% decline in younger adults and 17% in older adults.
