Elevated serum mtDNA in COVID-19 patients is linked to SARS-CoV-2 envelope protein targeting mitochondrial VDAC1, inducing apoptosis and mtDNA release
“These findings suggest that SARS-CoV-2 E-protein induces mitochondrial dysfunction, apoptosis, and mtDNA release via VDAC1 modulation. mtDNA that accumulates in the blood activates the cGAS-STING pathway, triggering inflammatory cytokine and chemokine expression that contribute to the cytokine storm and tissue damage”
These findings suggest that SARS-CoV-2 E-protein induces mitochondrial dysfunction, apoptosis, and mtDNA release via VDAC1 modulation. mtDNA that accumulates in the blood activates the cGAS-STING pathway, triggering inflammatory cytokine and chemokine expression that contribute to the cytokine storm and tissue damage
If anyone thinks musicians dropped like this before covid they are lying to themselves
“Bieber cancelling his tour due to long covid complications, Harry Styles recently cancelling shows due to covid and now Springsteen cancelling shows just 3 weeks into their world tour, 2023 will be the year touring musicians show us there is no return to normal with endemic covid”
She’s had covid “20-25” times since covid started—and that’s with confirmed positive tests at urgent care or the hospital because she has terrible symptoms with covid each and every time she’s had it. The doctor said “maybe your body’s not making the antibodies to fight it.”😭
“She’s had covid ‘20-25’ times since covid started—and that’s with confirmed positive tests at urgent care or the hospital because she has terrible symptoms with covid each and every time she’s had it. The doctor said ‘maybe your body’s not making the antibodies to fight it.’”😭
This is my 15th semester teaching RN and NP students about Covid 19 pathophysiology. Not a lot has changed except for how much damage we now know the virus causes. It still baffles me that people don’t know it’s airborne, don’t know the risks. 1
“#CovidIsNotOver This is my 15th semester teaching RN and NP students about Covid 19 pathophysiology. Not a lot has changed except for how much damage we now know the virus causes. It still baffles me that people don’t know it’s airborne, don’t know the risks. 1”
Educational Thread:
New Covid XEC symptom 'severely impacts daily functioning' warns doctor
“New Covid XEC symptom 'severely impacts daily functioning' warns doctor"
Dr Snieguole Geige: "The most common symptom we're observing is an intense and persistent fatigue that seems to linger longer than with previous variants."
"The most serious symptom is the potential for sudden, acute respiratory failure in individuals who may have previously only experienced mild to moderate symptoms."
New Covid XEC symptom 'severely impacts daily functioning' warns doctor
“The most serious symptom is the potential for sudden, acute respiratory failure in individuals who may have previously only experienced mild to moderate symptoms.. Someone can appear to be recovering and suddenly face a rapid decline, often due to microvascular complications in the lungs, leading to severe oxygen deprivation.."
SARS-CoV-2 can cause lasting damage to cells’ energy production
“SARS-CoV-2, the virus that causes COVID-19, can cause lasting damage to energy production by mitochondria in many organs of the body. Stopping the virus from hijacking mitochondrial energy production may be a novel way to prevent serious complications from SARS-CoV-2 infection.”
As someone who was disabled by Covid in 2020, unceremoniously kicked out of society, & then gaslit by everyone I encountered—which continues to this day—my heart really breaks for entertainers.
“Contract clauses often prevent artists from publicly speaking about Covid while on tour. They have been quietly canceling tours & disappearing, while everyone pretends it’s all very puzzling & mysterious. 🧵”
Favorable Antiviral Effect of Metformin on SARS-CoV-2 Viral Load in a Randomized, Placebo-Controlled Clinical Trial of COVID-19 | Clinical Infectious Diseases | Oxford Academic
“Favorable Antiviral Effect of Metformin on SARS-CoV-2 Viral Load in a Randomized, Placebo-Controlled Clinical Trial of COVID-19”
SARS-CoV-2 Delta variant induces severe damages in the nasal cavity from the first day post-infection in the Syrian hamster model.
“SARS-CoV-2 variant severe damages in the nasal cavity from the first day post-infection”
SARS-CoV-2 Delta variant induces severe damages in the nasal cavity from the first day post-infection