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Antigenic imprinting dominates humoral responses to new variants of SARS-CoV-2 in a hamster model of COVID-19
Antigenic imprinting dominates humoral responses to new variants of SARS-CoV-2 in a hamster model of COVID-19

Study at KU Leuven on hamsters finds that immunity from XBB.1.5 COVID-19 vaccine favors the original strain, limiting antibody response to newer variants like JN.1.

Highlights the challenge of updating vaccines for evolving SARS-CoV-2.

·biorxiv.org·
Antigenic imprinting dominates humoral responses to new variants of SARS-CoV-2 in a hamster model of COVID-19
Why protective antibodies fade after COVID-19 vaccines
Why protective antibodies fade after COVID-19 vaccines

While effective at preventing severe COVID-19, the protection you get from mRNA vaccines can fade within months.

Long-lasting immune cells that fight SARS-CoV-2 aren't usually found in mRNA-vaccinated people, unlike the immune cells for tetanus and flu.

·nih.gov·
Why protective antibodies fade after COVID-19 vaccines