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Comprehensive method for producing high-affinity mouse monoclonal antibodies of various isotypes against (4-hydroxy-3-nitrophenyl)acetyl (NP) hapten
Comprehensive method for producing high-affinity mouse monoclonal antibodies of various isotypes against (4-hydroxy-3-nitrophenyl)acetyl (NP) hapten

New protocol from Japan enables high-affinity monoclonal antibody production from single B cells in 6 days.

Cost-effective and works across antibody types, including for SARS-CoV-2 spike protein.

#Monoclonal Antibodies#early treatment#treatment#protocols
·cell.com·
Comprehensive method for producing high-affinity mouse monoclonal antibodies of various isotypes against (4-hydroxy-3-nitrophenyl)acetyl (NP) hapten
Obeldesivir for COVID-19 Is Safe, Reduces Time to Symptom Relief in High-Risk Patients
Obeldesivir for COVID-19 Is Safe, Reduces Time to Symptom Relief in High-Risk Patients

My note: Would like to see study on this drug with endpoints like time to recovery, severity of symptoms, long-term follow-up for post-acute symptoms. Not holding my breath. This is, after all, Giliad, the maker of remdesivir. Still, potential early treatment option here:

465 adults received either obeldesivir or a placebo for 5 days. The results showed that those on obeldesivir had a 0% hospitalization rate and lower mortality compared to 0.5% in the placebo group.

Patients taking obeldesivir also experienced quicker symptom relief and greater reductions in the virus levels. Overall, the drug was found to be generally safe and well-tolerated.

#obeldesevir#early treatment#treatment#antiviral
·infectiousdiseaseadvisor.com·
Obeldesivir for COVID-19 Is Safe, Reduces Time to Symptom Relief in High-Risk Patients
Metformin therapy and severity and mortality of SARS-CoV-2 infection: a meta-analysis | Oscanoa | Clinical Diabetology
Metformin therapy and severity and mortality of SARS-CoV-2 infection: a meta-analysis | Oscanoa | Clinical Diabetology
32 observational studies were included, combining to a total sample of 44306 participants. "Results suggested that metformin use was associated with a reduced risk of SARS-CoV-2 mortality."
#Metformin#Mortality#treatment#early treatment
·journals.viamedica.pl·
Metformin therapy and severity and mortality of SARS-CoV-2 infection: a meta-analysis | Oscanoa | Clinical Diabetology
A dual inhibitor of PIP5K1C and PIKfyve prevents SARS-CoV-2 entry into cells
A dual inhibitor of PIP5K1C and PIKfyve prevents SARS-CoV-2 entry into cells
“the development of new small molecule-based antiviral candidates is imperative to improve clinical outcomes against SARS-CoV-2. In this study, we identified UNI418, a dual PIKfyve and PIP5K1C inhibitor, as a new chemical agent that inhibits SARS-CoV-2 entry into host cells.”
the development of new small molecule-based antiviral candidates is imperative to improve clinical outcomes against SARS-CoV-2. In this study, we identified UNI418, a dual PIKfyve and PIP5K1C inhibitor, as a new chemical agent that inhibits SARS-CoV-2 entry into host cells.
#UNI418#antiviral#PIKfyve and PIP5K1C inhibitor#treatment#early treatment
·nature.com·
A dual inhibitor of PIP5K1C and PIKfyve prevents SARS-CoV-2 entry into cells