SARS-CoV-2 targets ribosomal RNA biogenesis 5
SARS-CoV-2 targets ribosomal RNA biogenesis
Covid General Articles, Discussions, Videos
Covid-19 may lead to longest period of peacetime excess mortality, says new Swiss Re report | Swiss Re
“Report suggests potential excess mortality in the general population of up to 3% for the US by 2033 and 2.5% in the UK, the longest period of elevated peacetime excess mortality in the US Key driver of excess mortality is the lingering impact of COVID-19; both as a direct cause of death, and as a contributor to cardiovascular mortality”
Report suggests potential excess mortality in the general population of up to 3% for the US by 2033 and 2.5% in the UK, the longest period of elevated peacetime excess mortality in the US Key driver of excess mortality is the lingering impact of COVID-19; both as a direct cause of death, and as a contributor to cardiovascular mortality
Tonight 8pm ET/5pm PT i'm doing a 90 minute livestream stand-up show on zoom. also on the show. Tickets are pay what you want
Discovery of orally bioavailable SARS-CoV-2 papain-like protease inhibitor as a potential treatment for COVID-19
Chinese researchers:
GZNL-P36 is a promising drug candidate for COVID-19 targeting a conserved viral enzyme, showing broad antiviral and anti-inflammatory effects.
Mouse trials: it reduces viral load, inflammation, and lung damage
U.S. May See A Healthy Thanksgiving—But Covid, RSV Could Spike Before Christmas, CDC Warns
November 22, 2024 “On Wednesday, the CDC warned it expects to see an increase in Covid and RSV levels in the coming weeks as large gatherings, travel and more time indoors allow disease to spread more easily person-to-person. The CDC recommends opening windows and doors for ventilation, wearing masks in crowded areas, practicing regular handwashing and being up-to-date on Covid and flu vaccinations to avoid getting sick. “
On Wednesday, the CDC warned it expects to see an increase in Covid and RSV levels in the coming weeks as large gatherings, travel and more time indoors allow disease to spread more easily person-to-person. The CDC recommends opening windows and doors for ventilation, wearing masks in crowded areas, practicing regular handwashing and being up-to-date on Covid and flu vaccinations to avoid getting sick.
Flu and COVID-19 cases continue to climb in Arizona
Nov 22, 2024: “Respiratory viruses continue to spread in Arizona. The Arizona Department of Health Services reported more than 1,000 cases of influenza last week and more than 2,100 cases of COVID-19.
Respiratory viruses continue to spread in Arizona. The Arizona Department of Health Services reported more than 1,000 cases of influenza last week and more than 2,100 cases of COVID-19.
I was a music journalist for years and have been going to gigs for over 20 years and the amount of tour cancellations is unprecedented
“I was a music journalist for years and have been going to gigs for over 20 years and the amount of tour cancellations is unprecedented”
If anyone thinks musicians dropped like this before covid they are lying to themselves
“Bieber cancelling his tour due to long covid complications, Harry Styles recently cancelling shows due to covid and now Springsteen cancelling shows just 3 weeks into their world tour, 2023 will be the year touring musicians show us there is no return to normal with endemic covid”
SARS-CoV-2 Transmission From People Without COVID-19 Symptoms
59% of all transmission came pre/asymptomatic transmission,
35% presymptomatic individuals 24% asymptomatic.
An orally available Mpro/TMPRSS2 bispecific inhibitor with potent anti-coronavirus efficacy in vivo
Researchers at The University of Hong Kong developed TMP1, an oral drug blocking coronavirus entry and replication.
Tested in mice and hamsters, it was effective against SARS-CoV-2 variants and drug-resistant strains.
Masks Off | Jess McAllen
“The push to criminalize face coverings puts everyone at risk”
The push to criminalize face coverings puts everyone at risk
CDC Weighs Lowering Infection Protections Even More
“CDC Weighs Lowering Infection Protections Even More”
CDC Weighs Lowering Infection Protections Even More
Report: 1 in 5 animals at zoo tested positive for SARS-CoV-2, perhaps from people
Report: 1 in 5 animals at zoo tested positive for SARS-CoV-2, perhaps from people
Report: 1 in 5 animals at zoo tested positive for SARS-CoV-2, perhaps from people
Institutional COVID denial has killed public health as we knew it. Prepare to lose several centuries of progress.
A plea to maskless health-care workers from vulnerable patients - Healthy Debate
“I politely asked her to wear it and told her I was immunocompromised. She rolled her eyes, held the mask in front of her face without actually putting it on. She leaned across me to hit the button, even though there was another set of buttons on the opposite side of the elevator. This felt like a deliberate attempt to violate my personal space and ensure I knew just how unhappy she was that I asked her to mask. As time went on and more people bought into the comfortable lie that COVID was over, it became harder to access safe medical care. Fewer and fewer staff were complying with mandates; eventually mandates were dropped altogether in favour of “mask-friendly” policies.”
I politely asked her to wear it and told her I was immunocompromised. She rolled her eyes, held the mask in front of her face without actually putting it on. She leaned across me to hit the button, even though there was another set of buttons on the opposite side of the elevator. This felt like a deliberate attempt to violate my personal space and ensure I knew just how unhappy she was that I asked her to mask.
As time went on and more people bought into the comfortable lie that COVID was over, it became harder to access safe medical care. Fewer and fewer staff were complying with mandates; eventually mandates were dropped altogether in favour of “mask-friendly” policies.
Intranasal delivery of a subunit protein vaccine provides protective immunity against JN.1 and XBB-lineage variants
“Intranasal protein vaccine with MF59-like adjuvant protects against SARS-CoV-2, including XBB variants.
In mice, it boosts mucosal immunity with durable neutralizing antibodies.”
As caught by ,
“As caught by @michael_hoerger,
CDC just modified their dashboard to make Covid transmission look lower on November 18, 2024.
‘The underlying data are identical. However, the Y axis is rescaled to make everything seem lower.’”
Low dose rapamycin in a study was shown to increase interferon antiviral response. Participants reported lower rates of infections for 1 year. Improved T cell response. This drug is being trialed for . Amy Proal PhD 🧵
“Low dose rapamycin in a study was shown to increase interferon antiviral response. Participants reported lower rates of infections for 1 year. Improved T cell response. This drug is being trialed for #LongCovid. Amy Proal PhD @microbeminded2 🧵”
Politician Deaths During COVID Pandemic
“The Long COVID Foundation curated a list of active (or very recently active) judges, politicians, and the like located in the United States who have passed away from any cause between 2020 into November of 2024. The total on the list is 466, 261 with a known cause (excluding those that died via accidents, murder, and suicide). “
The Long COVID Foundation curated a list of active (or very recently active) judges, politicians, and the like located in the United States who have passed away from any cause between 2020 into November of 2024. The total on the list is 466, 261 with a known cause (excluding those that died via accidents, murder, and suicide).
We analyzed the deaths of United States Politicians during the & found some interesting statistics.
“We analyzed the deaths of United States Politicians during the #COVIDPandemic & found some interesting statistics.
From 2020-2024 (into November) at least 466 active (or recently active) politicians, judges, & the like passed away. “
COVID-19 hitches a ride on mucus to spread deep into lungs, live imaging shows
COVID-19 hitches a ride on mucus to spread deep into lungs, live imaging shows.
Investigators observed that the movement of mucus can spread the COVID-19 virus inside the respiratory tract, where it later forms aerosols that infect other people.
The Platform Trial In COVID-19 priming and BOOsting (PICOBOO): the immunogenicity, reactogenicity, and safety of licensed COVID-19 vaccinations administered as a second booster in BNT162b2 primed individuals aged 18-50 and 50-70 years old.
PICOBOO randomized trial, evaluating second boosters after mRNA priming. 1) novavax is more durable 2) mRNA vaccines have higher antibody responses 3) novavax has fewer side effects
Pfizer antibody levels drop around 40% between 1 month to 3 months post vax. Moderna is less, w/ a 14% drop in younger adults, 26% decline in older adults. Novavax had only a 3% decline in younger adults and 17% in older adults.
The TL;DR is that Dana Parish interviewed former CDC Director Redfield and he finally revealed what some of us already knew (if you saw the circulated NIH grant proposal with track changes, you’ve known) that… the SARS2 virus was really conceived in a lab in North Carolina.
I’ve burned a lot of bridges over the past few years and my kids are homeschooled. I no longer have 1st person accounts of COVID’s toll on people’s health. Are people in your life sicker? Are the kids sicker? I need to be re-tethered… please share your stories.
“I’ve burned a lot of bridges over the past few years and my kids are homeschooled. I no longer have 1st person accounts of COVID’s toll on people’s health. Are people in your life sicker? Are the kids sicker? I need to be re-tethered… please share your stories.”
(🧵It's the Сονіd, ѕtυріd!): Viewing the US election through the lens of the ongoing ЅАRЅ-Соν-2 раndеmіc.
“(🧵It's the Сονіd, ѕtυріd!): Viewing the US election through the lens of the ongoing ЅАRЅ-Соν-2 раndеmіc.
(My hot take on what happened, and where things are headed. Prelude to the final 🧵in the "How does it end" series)…
…No country can expect sustained 3% growth, if 3% of its workforce drops out every year.
There is no path forward - for the US or any other country - without addressing this. Repeated covid infections are not a sustainable situation.”
Here is the video from today’s hicpac meeting showing that most of them voted against n95 respirators for airborne pathogens.
“Here is the video from today’s @CDCgov hicpac meeting showing that most of them voted against n95 respirators for airborne pathogens.”
Twitter using all our posts to train AI. Chat, are we about to make AI become covid cautious?
“Twitter using all our posts to train AI. Chat, are we about to make AI become covid cautious?”
Thread: Public Comment on HICPAC Concerns 🧵
“Thread: Public Comment on HICPAC Concerns 🧵
1/ I’m here not to address HICPAC directly, but to speak to those listening—healthcare professionals, patients, and advocates—who are committed to public health and safety.
Let me highlight several critical concerns.”
🔥📣 I am thrilled to bring you this fascinating, shocking interview with former CDC Director, Dr. Robert Redfield. 👀 I almost fell off my seat a number of times. 👀
“🔥📣 I am thrilled to bring you this fascinating, shocking interview with former CDC Director, Dr. Robert Redfield. 👀 I almost fell off my seat a number of times. 👀”
COVID map update reveals shift in "very high" water virus levels
November 12, 2024
“Between October 27 and November 2, wastewater sampling from New Mexico revealed ‘very high’ levels of the virus, with ‘high’ levels being detected in Oregon, Arkansas, and Maine, according to the U.S. Centers for Disease Control and Prevention (CDC).”
Between October 27 and November 2, wastewater sampling from New Mexico revealed "very high" levels of the virus, with "high" levels being detected in Oregon, Arkansas, and Maine, according to the U.S. Centers for Disease Control and Prevention (CDC).