COVID increases the risk of secondary infections by impairing mucosal clearance.
"Our results demonstrate profound ciliary loss in the nasal epithelium even in subjects with mild disease and shed light on mechanisms that... probably predispose patients to secondary infections."
COVID increases the risk of secondary infections by impairing mucosal clearance.
"Our results demonstrate profound ciliary loss in the nasal epithelium even in subjects with mild disease and shed light on mechanisms that... probably predispose patients to secondary infections."
My note: Would like to see study on this drug with endpoints like time to recovery, severity of symptoms, long-term follow-up for post-acute symptoms. Not holding my breath. This is, after all, Giliad, the maker of remdesivir. Still, potential early treatment option here:
465 adults received either obeldesivir or a placebo for 5 days. The results showed that those on obeldesivir had a 0% hospitalization rate and lower mortality compared to 0.5% in the placebo group.
Patients taking obeldesivir also experienced quicker symptom relief and greater reductions in the virus levels. Overall, the drug was found to be generally safe and well-tolerated.
“So a healthcare worker went to an event, and didn’t want to remove their mask for the photo.
‘Don’t worry, send us a head shot and we’ll digitally include it.’
They are literally swapping heads to try to get out of reality.”
“A Plea to Maskless Healthcare Workers from Vulnerable Patients If you see a mask - wear a mask. Better yet - wear a mask all the time and show us you understand that we're still IN a pandemic. We are depending on you to keep us safe - please don't betray that.”
“‘Everyone dies someday! Get out and live!’
I’ve lost count of how many people have said this to me. People who assume I’m ‘choosing’ to stay home in bed or who think fear of Covid is the only determining factor to my not socializing more.
This is NOT a choice 🧵/1”
“In U.S., ‘The number of annual traffic fatalities in Washington state has jumped from 528 in 2019 to 810 in 2023, a 51% increase since 2019.. 2023 [was] the deadliest since 1990.. Speculation as to why traffic fatalities increased varied.’
IMO, the main reason is the cognitive dysfunction caused by SARS-CoV-2.
October, 2024: “The UK's health body has warned that COVID-19 spreads ‘very easily through close contact with people who have the virus’ and you can still be infectious for ‘up to 10 days’”
Me: "How was the operation?"
Her: "Oh, it was cancelled again."
Me: "Three times? That is ridiculous."
Her: "No, it's four now. Twice they've cancelled it because they were sick, and twice they've cancelled it because I was sick."
Me: "When you say sick, what do you mean?"
“The most serious symptom is the potential for sudden, acute respiratory failure in individuals who may have previously only experienced mild to moderate symptoms.. Someone can appear to be recovering and suddenly face a rapid decline, often due to microvascular complications in the lungs, leading to severe oxygen deprivation.."
“Every one of these subvariants is distinct enough that a whole swathe of people are no longer immune to it and it can infect them. That’s why you see this constant undulatory pattern which doesn’t look seasonal at all,” he says. Adding in seasonal factors, such as cooler weather forcing people indoors and children returning to school, and the conditions are frequently conducive to a new wave.”
“SARS-CoV-2, the virus that causes COVID-19, can cause lasting damage to energy production by mitochondria in many organs of the body. Stopping the virus from hijacking mitochondrial energy production may be a novel way to prevent serious complications from SARS-CoV-2 infection.”
“After a year of the pandemic in Arkhangelsk, 59.7% 95% confidence intervals (CI) (56.7; 62.6) of the surveyed population had had COVID-19. Among those who had been infected, symptomatic cases comprised 47.1% 95% CI (43.2; 51.0), with 8.6% 95% CI (6.6; 11.1) of them having been hospitalized. Of the asymptomatic cases, 96.2% were not captured by the healthcare system. Older age was positively associated, while smoking showed a negative association with symptomatic COVID-19. Individuals older than 65 years, and those with poor self-rated health were more likely to be hospitalized. Conclusion More than half of the infected individuals were not captured by the healthcare-based registry, mainly those with asymptomatic infections.”
“this study investigated the airborne transmission of respiratory diseases in the hospital elevator by comparison to the conference room.”
“The results showed that the infection probability in the elevator with 5 min was higher than that in the conference room with 50 min.”
Anti-Viral Impact of Metformin “When AMPK was activated in Calu3 and Caco2 cell lines using metformin, there was a remarkable suppression of SARS-CoV-2 infectious titers, with up to 99% reduction observed in infected cells.”
Metformin suppresses SARS-CoV-2 in cell culture
“Just so people reading this know:
When you have covid, you exhale covid particles into the air. Even with just ordinary breathing.
Those particles can then float on the air for hours.”
