“One big, very basic issue is that most docs don't know what bird flu/avian flu/hpai is and that it's an Influenza A
So then it can't even cross their mind to consider HPAI if they get a flu A+ patient
Add to that fact that many are not aware of the growing h5n1 issue.”
“This 13-year-old received 3 antivirals (oseltamavir, amantadine, and baloxavir) PLUS plasma exchange for #H5N1. In over a decade as an ID doctor, I've never used such measures for #Influenza — not even during H1N1.
“December 26, 2024: BREAKING
H5N1 D1.1 is adapting to humans.
There are now two CRITICAL cases BOTH with multiple human adaptive mutations (BC teen,Louisiana case). A BirdFlu pandemic is coming our way.”
“They’ll be testing to see if the H5N1 virus in the BC teen is binding the sialic acid-α2,6-galactose (SAα2,6Gal) receptor with high affinity. If so, the leap necessary for efficient human to human has been made.
In order for efficient H-H transmission of avian viruses there needs to be a change from preferential recognition by the virus hemagglutinin of α2-3-sialyl-galactose-terminating host cell receptors, predominant in avian respiratory and gastrointestinal epithelia, to those terminating in α2-6-sialyl-galactose, which predominate in the human upper respiratory tract.”
“1918. You recognize that year. The year of the Spanish Flu Pandemic.
Debunk 🧵.”