Long Covid/PASC (general)

(MY NOTE: China vaccines are not MRNA technology. The better reduction in long-term Long Covid symptoms relative to multiple boosters compared to studies with MRNA patients is significant. Would like to see Long Covid data out of Cuba, a country that also did not use MRNA.)

Summary:

New study of 74,000 participants found:

-those infected with COVID had more other infections (including bacterial, influenza & mycoplasma infections)

-COVID reinfections had milder acute-phase symptoms but led to higher rate & severity of Long Covid

“Analysis of 68,200 valid responses revealed that the most frequent long COVID symptoms include fatigue (30.53%), memory decline (27.93%), decreased exercise ability (18.29%), and brain fog (16.87%). These symptoms were less prevalent among those infected only once: fatigue (24.85%), memory decline (18.11%), and decreased exercise ability (12.52%), etc. Women were more likely to experience long COVID, with symptoms varying by age group, except for sleep disorders and muscle/joint pain, which were more common in older individuals. Northern China exhibits a higher prevalence of long COVID, potentially linked to temperature gradients. Risk factors included underlying diseases, alcohol consumption, smoking, and the severity of acute infection (OR > 1, FDR < 0.05). Reinfection was associated with milder symptoms but led to a higher incidence and severity of long COVID (OR > 1, FDR < 0.05). Vaccination, particularly multiple boosters, significantly reduced long-term symptoms by 30%–70% (OR < 1, FDR < 0.05). COVID-19 participants also self-reported more bacterial, influenza and mycoplasma infections, and 8%–10% of patients felt SARS-CoV-2-induced chronic diseases.”

“Participants were randomly assigned via 2 × 3 parallel factorial randomisation (1:1:1:1:1:1) to receive metformin plus ivermectin, metformin plus fluvoxamine, metformin plus placebo, ivermectin plus placebo, fluvoxamine plus placebo, or placebo plus placebo.

When metformin was started within 3 days of symptom onset, the HR was 0·37 (95% CI 0·15–0·95). There was no effect on cumulative incidence of long COVID with ivermectin (HR 0·99, 95% CI 0·59–1·64) or fluvoxamine (1·36, 0·78–2·34) compared with placebo.

There was no effect on cumulative incidence of long COVID with ivermectin (HR 0·99, 95% CI 0·59–1·64) or fluvoxamine (1·36, 0·78–2·34) compared with placebo.

…Outpatient treatment with metformin reduced long COVID incidence by about 41%, with an absolute reduction of 4·1%, compared with placebo. Metformin has clinical benefits when used as outpatient treatment for COVID-19 and is globally available, low-cost, and safe.”

King’s College of London: “Long COVID symptoms prevalent among healthcare workers”

New research has found that 33.6% of surveyed healthcare workers in England report symptoms consistent with post-COVID syndrome

"I don't think the messaging has been strong enough," says David Putrino, the director of rehabilitation innovation for Mount Sinai Health System. "It is very clear that this is not a typical response to exercise."

“The tissue samples from long COVID patients revealed severe muscle damage, a disturbed immune response, and a buildup of microclots.”

“It’s only October 11th and we now have 3x the number of referrals to our Long COVID clinic than usual. THREE TIMES MORE.

50% of our referrals contracted COVID in 2024. Of those, half contracted COVID over summer 2024.

COVID prevention is the only to way to prevent Long COVID. We have to do better.”

“This implies that some people may be genetically predisposed to developing post-viral syndromes after COVID-19.

Overall, these findings provide important insights into the genetic basis of Long COVID.

“HEALTH UPDATE:

It has officially been one year since I contracted Covid-19 while on set for my movie that I’ve been working on.

I was once a very healthy 31-year old man, but now every day is a struggle for me.

A THREAD... 🧵”

Long-COVID rate among disabled people double that of able-bodied

People with disabilities are also more likely to have severe COVID-19, face treatment refusals, and be hospitalized, the researchers say.

“Our ‘new normal’ should not include at least 11% of the population falling chronically ill with long Covid after each infection…

…The narrative that we are back to normal.. is not based in reality."

AAI has written to @SenSanders to offer support for his recently introduced legislation, the "Long COVID Research Moonshot Act" which would, among other things, provide NIH with $1 billion/year for 10 years to support Long COVID research.

Read it here:

Simply Red singer Mick “revealed he's suffering with long COVID and is struggling with the after-effects of the virus.

Speaking to The Sun, Mick told how he suffers with heart palpitations and insomnia, explaining how he often wakes up in the middle of the night 'with my heart going ba-boom, ba-boom.'”

“The popular drag artist Themme Fatale has announced their retirement due to Long COVID:

“That’s all folks: Live, laugh, look out for each other during a mass disabling event.”

“It’s not over. And you are leaving people behind.”

The pandemic's ongoing impact on disabled people.