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Emerging viral threats combated by a potent new dual lipid kinase inhibitor
Emerging viral threats combated by a potent new dual lipid kinase inhibitor
“The researchers demonstrated selective dual inhibition of the lipid kinases PIP4K2C and PIKfyve by RMC-113 and target engagement by its related clickable analog. Advanced lipidomics revealed alteration of SARS-CoV-2-induced phosphoinositide signature by RMC-113 and linked its antiviral effect with functional PIP4K2C and PIKfyve inhibition. The researchers also discovered PIP4K2C's roles in SARS-CoV-2 entry, RNA replication, and assembly/egress, validating…”
#PIKfyve and PIP5K1C inhibitor#antiviral#treatment#research#PIKfyve and PIP4K2C inhibitor
·flip.it·
Emerging viral threats combated by a potent new dual lipid kinase inhibitor
Karen Asp 🌱🐾✍️👟 (@karenaspwriter) on X
Karen Asp 🌱🐾✍️👟 (@karenaspwriter) on X

“Bumped into neighbor while walking 🐶. I've seen her walking more recently & we got talking.

She's on disability from work b/c of memory issues. She can't drive or do household tasks & is forgetting things she should know. Her writing has even changed.

She's 54. The kicker?”

#Anecdote#Brain#Memory#Cognition#Covid Isn't Over#CDC failure#minimizing and outright propaganda#media and government lies#Discussion
·x.com·
Karen Asp 🌱🐾✍️👟 (@karenaspwriter) on X
A Chronically Ill Earth: COVID Organizing as a Model Climate Response in Los Angeles
A Chronically Ill Earth: COVID Organizing as a Model Climate Response in Los Angeles
Violet Affleck: “…the climate resilience our society needs to build relies upon the skills and systems of pacing that disabled and chronically ill people have built to manage both their own symptoms and the ongoing COVID-19 pandemic.”
#Covid History#analysis#Discussion#Violet Affleck#related#Climate
·yaleglobalhealthreview.com·
A Chronically Ill Earth: COVID Organizing as a Model Climate Response in Los Angeles
Partnership formed to confront rise in illness, premature death in young Americans
Partnership formed to confront rise in illness, premature death in young Americans
“The health trajectory of increasingly younger adults has changed dramatically since COVID-19,”
The health trajectory of increasingly younger adults has changed dramatically since COVID-19,”
#Excess Mortality#Mortality#early adult deaths#young people#Chronic Illness#public health#inevitable effects of Forever Covid#CDC failure#consequences#related#Post-Acute Conditions#Long Covid#Covid Isn't Over#organ damage
·insurancenewsnet.com·
Partnership formed to confront rise in illness, premature death in young Americans
Thread by @SolidEvidence on Thread Reader App
Thread by @SolidEvidence on Thread Reader App

“Persistent infections are training grounds for pathogens.

People worry about ‘gain of function’ work, but failing to continue treating the 40+ million people in the world living with HIV would be the largest and most dangerous gain of function ‘experiment’ in history.”

Persistent infections are training grounds for pathogens. People worry about ‘gain of function’ work, but failing to continue treating the 40+ million people in the world living with HIV would be the largest and most dangerous gain of function ‘experiment’ in history.
#related#HIV#Viral Persistence
·threadreaderapp.com·
Thread by @SolidEvidence on Thread Reader App