‘This is a simple trick to overlay a grid or a mock-up over a page you're styling. It will also allow you to edit content directly in the browser to see how your layout behaves depending on various lines of text.’

This may be worth looking into. I waffle on whether this sort of thing is ultimately a good decision — you're relying on someone else's framework, it takes a while to learn and master, and once you decide to go with it you're essentially stuck with it. But isn't that the case with any pseudo-framework developed for a website design? I should test this on a little project.

"Blueprint is a CSS framework, which aims to cut down on your CSS development time. It gives you a solid CSS foundation to build your project on top of, with an easy-to-use grid, sensible typography, and even a stylesheet for printing."