This may be worth looking into. I waffle on whether this sort of thing is ultimately a good decision — you're relying on someone else's framework, it takes a while to learn and master, and once you decide to go with it you're essentially stuck with it. But isn't that the case with any pseudo-framework developed for a website design? I should test this on a little project.
"Blueprint is a CSS framework, which aims to cut down on your CSS development time. It gives you a solid CSS foundation to build your project on top of, with an easy-to-use grid, sensible typography, and even a stylesheet for printing."