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Evo-Devo (Despacito Biology Parody) | A Capella Science
Evo-Devo (Despacito Biology Parody) | A Capella Science
This is how we go from single cells to people. Support A Capella Science: http://patreon.com/acapellascience Subscribe! https://www.youtube.com/subscription_center?add_user=acapellascience MP3: https://timblais.bandcamp.com/track/evo-devo ---------------- A CAPELLA SCIENCE STUFF: Patreon: http://patreon.com/acapellascience Facebook: http://facebook.com/acapellascience Twitter: http://twitter.com/acapellascience Bohemian Gravity poster: https://store.dftba.com/products/bohemian-gravity-poster Follow me @acapellascience on Twitter, Instagram, Snapchat! EVO-DEVO Huxley B. Mac. Oh Carroll, Carroll Gould, Stephen Jay yeah D-D-D-D-Davidson and Peter See One cell divide and decide on a thousand fates Did you ever figure how they know? B. Mac. We Are built of modules combined in a planned out way Each new piece must be told where to go Oh Now there's a science helping us to understand How our cells encode this architectural plan Signalling each other with genetic tools oh Oh yeah Wow Phenotype the interface for mouse and man Genotype the files and the subprograms What then are the switches, circuit boards and boot code? Evo-Devo Looking at the logic in the ways that we grow Every gene directed by a signal key code Proteins that can activate, enhance or veto Evo-Devo Signals are controlled by other genes that signal Calculating in a network labyrinthal Where the heart and liver and the hands and feet go Signal mapping tells each region what it ought to be yo With circuits so deeply built upon They're older than the Paleo The Paleozoic Era baby In a crucial pathway changes tend to get torpedoed Where they go calamity goes As this cyclopic sheep knows.. See down they cascade like a domino Like you and I drosophila The path that makes us optical Was laid a long long time ago Back before we blew up the cambrian like a bomb bomb Now my eye protein can make you see out of your bom bom And Hedgehog and its relatives like Indian and Sonic Set up set up in a gradient on segments embryonic Split forebrains and asymmetric parts depend upon it Flipping on genetic switches and logic From devo to evo Adult and embryo Mostly don't evolve in the genes of the genome Safer the mutation aimed at regulation Keep the building blocks and swap their activation From devo to evo Parts have alter egos Homologs evolved from repeats in the schema Switch a couple bases in the proper places You'll be watching flies grow legs out of their faces oh yeah Evo-Devo Stick around for Modern Synthesis the sequel Only by combining can a new theory grow Evolution and development amigos Evo-Devo Signals trigger patterns of complexity so Switching up the switches of a signalling node Gives a modular and simple way to evolve Look at how our spinal segments generate a neat row Built on a molecular clock One cycle, one vertebra One vertebra one vertebra baby Speeding up its rate is snakes' developmental cheat code That and where a lizard's feet grow They turn off distal aminos Evo-Devo This is how we go from single cells to people Every generation and in life primeval Life in variations endless and beautiful Badaboom From devo to evo Larva to mosquito Patterns are resolved as the signals proceed yo Map out a gene with a glow tag Kill it with a morpholino Short oligo morpholino baby From devo to evo Voyage of the Beagle Body plans evolve when proteins steer the genome In this manner life's beauty grows Aesthetica in vivo Evo-Devo
·youtube.com·
Evo-Devo (Despacito Biology Parody) | A Capella Science
Pi
Pi
The 1998 surrealist psychological thriller stars Sean Gullette as a mathematician who becomes obsessed with searching for patterns in the universe as part of a quest for meaning. Twenty-five…
·a24films.com·
Pi
okazakitomohiro on Twitter
okazakitomohiro on Twitter
pic.twitter.com/toQKsr0XU7— okazakitomohiro (@oo_kk_aa) September 11, 2023
·x.com·
okazakitomohiro on Twitter
Gordon on Twitter
Gordon on Twitter
bringing this energy pic.twitter.com/ALxySCOCe7— Gordon (@gordonbrander) September 10, 2023
·x.com·
Gordon on Twitter
Looom
Looom
We’d like to show you a new way to create hand-drawn animation. So playful you’ll think it’s a toy, but it's secretly a robust app with a reimagined UI for animators and creators.
·iorama.studio·
Looom
Introducing Mercury OS
Introducing Mercury OS
A speculative vision of the operating system, driven by humane design principles.
·uxdesign.cc·
Introducing Mercury OS
1 Year of VR Research
1 Year of VR Research
Wow, wasn't expecting so much when I started editing this together. Easy to forget how differently we thought about these technologies only a year ago. Which was so different from a year before that. And the year before that.We're now in our 4th year of research, but this was our 1st year with so much support, and as a nonprofit, and we're really excited about it all!If you want to find out more about any of the projects shown, you can probably find them on http://elevr.com. Or if you want to contact the research group you can use the gmail address "elevirtual".Our group is part of HARC at YCR: https://harc.ycr.org
·youtube.com·
1 Year of VR Research
Unflattening — Nick Sousanis
Unflattening — Nick Sousanis
The primacy of words over images has deep roots in Western culture. But what if the two are inextricably linked in meaning-making? In this experiment in visual thinking, drawn in comics, Nick Sousanis defies conventional discourse to offer readers a stunning work of graphic art and a serious inquiry into the ways humans construct knowledge.
·hup.harvard.edu·
Unflattening — Nick Sousanis
The Humane Representation of Thought
The Humane Representation of Thought
Closing keynote at the UIST and SPLASH conferences, October 2014.Preface: http://worrydream.com/TheHumaneRepresentationOfThought/note.htmlReferences to baby-steps towards some of the concepts mentioned:Dynamic reality (physical responsiveness): - The primary work here is Hiroshi Ishii's "Radical Atoms": http://tangible.media.mit.edu/project/inform/ - but also relevant are the "Soft Robotics" projects at Harvard: http://softroboticstoolkit.com - and at Otherlab: http://www.youtube.com/watch?v=gyMowPAJwqo - and some of the more avant-garde corners of material science and 3D printingDynamic conversations and presentations: - Ken Perlin's "Chalktalk" changes daily; here's a recent demo: http://bit.ly/1x5eCOXContext-sensitive reading material: - http://worrydream.com/MagicInk/"Explore-the-model" reading material: - http://worrydream.com/ExplorableExplanations/ - http://worrydream.com/LadderOfAbstraction/ - http://ncase.me/polygons/ - http://www.redblobgames.com/pathfinding/a-star/introduction.html - http://www.earthprimer.com/ Evidence-backed models: - http://worrydream.com/TenBrighterIdeas/ Direct-manipulation dynamic authoring: - http://worrydream.com/StopDrawingDeadFish/ - http://worrydream.com/DrawingDynamicVisualizationsTalk/ - http://tobyschachman.com/Shadershop/ - http://aprt.usModes of understanding: - Jerome Bruner: http://www.amazon.com/dp/0674897013 - Howard Gardner: http://www.amazon.com/dp/0465024335 - Kieran Egan: http://www.amazon.com/dp/0226190390 Embodied thinking: - Edwin Hutchins: http://www.amazon.com/dp/0262581469 - Andy Clark: http://www.amazon.com/dp/0262531569 - George Lakoff: http://www.amazon.com/dp/0465037712 - JJ Gibson: http://www.amazon.com/dp/0898599598 - among others: http://en.wikipedia.org/wiki/Embodied_cognitionI don't know what this is all about: - http://worrydream.com/ABriefRantOnTheFutureOfInteractionDesign/ - http://worrydream.com/ABriefRantOnTheFutureOfInteractionDesign/responses.html ---Abstract:New representations of thought — written language, mathematical notation, information graphics, etc — have been responsible for some of the most significant leaps in the progress of civilization, by expanding humanity’s collectively-thinkable territory.But at debilitating cost. These representations, having been invented for static media such as paper, tap into a small subset of human capabilities and neglect the rest. Knowledge work means sitting at a desk, interpreting and manipulating symbols. The human body is reduced to an eye staring at tiny rectangles and fingers on a pen or keyboard.Like any severely unbalanced way of living, this is crippling to mind and body. But it is also enormously wasteful of the vast human potential. Human beings naturally have many powerful modes of thinking and understanding. Most are incompatible with static media. In a culture that has contorted itself around the limitations of marks on paper, these modes are undeveloped, unrecognized, or scorned.We are now seeing the start of a dynamic medium. To a large extent, people today are using this medium merely to emulate and extend static representations from the era of paper, and to further constrain the ways in which the human body can interact with external representations of thought.But the dynamic medium offers the opportunity to deliberately invent a humane and empowering form of knowledge work. We can design dynamic representations which draw on the entire range of human capabilities — all senses, all forms of movement, all forms of understanding — instead of straining a few and atrophying the rest.This talk suggests how each of the human activities in which thought is externalized (conversing, presenting, reading, writing, etc) can be redesigned around such representations.---Art by David Hellman.Bret Victor -- http://worrydream.com
·vimeo.com·
The Humane Representation of Thought
Sarah Constantin on Twitter
Sarah Constantin on Twitter
How do you feel about learning or entering fields/industries where the state of the art is very advanced, there are lots of good tools, and the average professional is is highly sophisticated?— Sarah Constantin (@s_r_constantin) March 17, 2023
·twitter.com·
Sarah Constantin on Twitter
Max Kreminski on Twitter
Max Kreminski on Twitter
much HCI work assumes users come in w/ a fixed intent to accomplish a specific task & use tools to fulfill that intent as directly as possiblecreative tools challenge this view: creative intent is always formed *in conversation with* tools/materials https://t.co/5VbOu1EMv3— Max Kreminski (@maxkreminski) May 16, 2019
·twitter.com·
Max Kreminski on Twitter
andrew blinn on Twitter
andrew blinn on Twitter
daily reminder that everywhere around you, professedly platonic solids privately bustle with ungovernable fibrations https://t.co/XNjwmitnV5— andrew blinn (@disconcision) April 9, 2021
·x.com·
andrew blinn on Twitter
Take Away Phoenix
Take Away Phoenix
| Subscribe for more: http://bit.ly/blogosubs"Take Away Phoenix" is a 21 minutes movie where you can see the band Phoenix playing four songs for La Blogotheq...
·youtube.com·
Take Away Phoenix
cristóbal (in san francisco) on Twitter
cristóbal (in san francisco) on Twitter
computers are communication devices pic.twitter.com/sObhNq8m3I— cristóbal (in san francisco) (@tobyshooters) June 26, 2023
·twitter.com·
cristóbal (in san francisco) on Twitter
Max Kreminski on Twitter
Max Kreminski on Twitter
key casual creator design insight: resist the temptation to seamlessnessdrawing attention to seams can help novice users understand how pieces are put together, & if something already looks a bit messy there's less anxiety about further messing it uphttps://t.co/PW8xH0InX8— Max Kreminski (@maxkreminski) May 22, 2023
·twitter.com·
Max Kreminski on Twitter