Covid

Covid

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Ineffective neutralization of the SARS-CoV-2 Mu variant by convalescent and vaccine sera
Ineffective neutralization of the SARS-CoV-2 Mu variant by convalescent and vaccine sera
On August 30, 2021, the WHO classified the SARS-CoV-2 Mu variant (B.1.621 lineage) as a new variant of interest. The WHO defines “comparative assessment of virus characteristics and public health risks” as primary action in response to the emergence of new SARS-CoV-2 variants. Here, we demonstrate that the Mu variant is highly resistant to sera from COVID-19 convalescents and BNT162b2-vaccinated individuals. Direct comparison of different SARS-CoV-2 spike proteins revealed that Mu spike is more resistant to serum-mediated neutralization than all other currently recognized variants of interest (VOI) and concern (VOC). This includes the Beta variant (B.1.351) that has been suggested to represent the most resistant variant to convalescent and vaccinated sera to date (e.g., Collier et al, Nature, 2021; Wang et al, Nature, 2021). Since breakthrough infection by newly emerging variants is a major concern during the current COVID-19 pandemic (Bergwerk et al., NEJM, 2021), we believe that our findings are of significant public health interest. Our results will help to better assess the risk posed by the Mu variant for vaccinated, previously infected and naïve populations. ### Competing Interest Statement The authors have declared no competing interest.
gabe70·biorxiv.org·
Ineffective neutralization of the SARS-CoV-2 Mu variant by convalescent and vaccine sera
How to Squander a Medical Miracle — Pixel Envy
How to Squander a Medical Miracle — Pixel Envy
Christopher Ingraham, of the Why Axis newsletter: The net result of this relentless pressure: even in the midst of a variant surge that’s proven especially lethal in conservative areas, nearly 40 percent of Republicans say they’re either unwilling to get the vaccine or uncertain about it, compared to just 15 percent of Democrats. But the […]
gabe70·pxlnv.com·
How to Squander a Medical Miracle — Pixel Envy
Florida grapples with COVID-19's deadliest phase yet
Florida grapples with COVID-19's deadliest phase yet
MIAMI (AP) — Funeral director Wayne Bright has seen grief piled upon grief during the latest COVID-19 surge. A woman died of the virus, and as her family was planning the funeral, her mother was also struck down.
gabe70·apnews.com·
Florida grapples with COVID-19's deadliest phase yet
Covid Trajectories
Covid Trajectories
I updated the covdata package for the first time in a while, as I’ll be using it to teach in the near future. As a side-effect, I ended up taking a look at what the ongoing polarization or divergence of the COVID experience is like in different parts of the United States. Here I use county-level data to draw out some of the trends. The idea is to take the time series of COVID-19 deaths and split it into deciles by some county-level quantity of interest.
gabe70·kieranhealy.org·
Covid Trajectories
Comparing SARS-CoV-2 natural immunity to vaccine-induced immunity: reinfections versus breakthrough infections
Comparing SARS-CoV-2 natural immunity to vaccine-induced immunity: reinfections versus breakthrough infections
Background Reports of waning vaccine-induced immunity against COVID-19 have begun to surface. With that, the comparable long-term protection conferred by previous infection with SARS-CoV-2 remains unclear. Methods We conducted a retrospective observational study comparing three groups: (1)SARS-CoV-2-naïve individuals who received a two-dose regimen of the BioNTech/Pfizer mRNA BNT162b2 vaccine, (2)previously infected individuals who have not been vaccinated, and (3)previously infected and single dose vaccinated individuals. Three multivariate logistic regression models were applied. In all models we evaluated four outcomes: SARS-CoV-2 infection, symptomatic disease, COVID-19-related hospitalization and death. The follow-up period of June 1 to August 14, 2021, when the Delta variant was dominant in Israel. Results SARS-CoV-2-naïve vaccinees had a 13.06-fold (95% CI, 8.08 to 21.11) increased risk for breakthrough infection with the Delta variant compared to those previously infected, when the first event (infection or vaccination) occurred during January and February of 2021. The increased risk was significant ( P
gabe70·medrxiv.org·
Comparing SARS-CoV-2 natural immunity to vaccine-induced immunity: reinfections versus breakthrough infections
Israeli data: How can efficacy vs. severe disease be strong when 60% of hospitalized are vaccinated?
Israeli data: How can efficacy vs. severe disease be strong when 60% of hospitalized are vaccinated?
A surge involving the rapidly-transmitting Delta variant in heavily vaccinated countries has led to much hand-wringing that the vaccines are not effective against Delta, or vaccine efficacy wanes after 4-6 months. This has fueled anti-vaccine sentiment suggesting the vaccines are not working, and causing much stress in vaccinated people that they are not as protected as they thought they would be. In this post, I will focus on vaccine efficacy vs. severe disease/hospitalization, which is the ke
gabe70·covid-datascience.com·
Israeli data: How can efficacy vs. severe disease be strong when 60% of hospitalized are vaccinated?
My Kids’ School Won’t Reinstate Masks Despite a Recent Surge in COVID Cases. Here’s What I Chose to Do.
My Kids’ School Won’t Reinstate Masks Despite a Recent Surge in COVID Cases. Here’s What I Chose to Do.
Georgia’s Cobb County School District had parents choose between virtual and in-person learning, then lifted its mask mandate. Many families are frantically figuring out how to navigate this reality. ProPublica reporter Nicole Carr is one of them.
gabe70·propublica.org·
My Kids’ School Won’t Reinstate Masks Despite a Recent Surge in COVID Cases. Here’s What I Chose to Do.
How the Pandemic Now Ends
How the Pandemic Now Ends
Cases of COVID-19 are rising fast. Vaccine uptake has plateaued. The pandemic will be over one day—but the way there is different now.
gabe70·theatlantic.com·
How the Pandemic Now Ends
Response to Student Evaluations, Sarah E. Smith
Response to Student Evaluations, Sarah E. Smith
You’ve asked me to write a response to my student evaluations. I’m sitting in my living room, my feet are cold because I haven’t been wearing shoes. Who wears shoes to work at home? My dog runs into the room and then looks at me and runs out. “If you pee on the carpet one more time, I swear to god!” I yell in his direction. My students have heard me yell the same thing at him during class. “The quiz on this section will be an asynchronous OH MY GOD YOU DID NOT JUST DO THAT TO MY CARPET AGAIN ess
gabe70·qmwproject.com·
Response to Student Evaluations, Sarah E. Smith