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It’s surprising how many people are resistant to doing things with no agenda. Often, when I ask someone why they’re not doing something they seem good at, they’ll say, “Oh, it’s not going anywhere.” / “I don’t have enough time.” / “I started too late anyway.” They would rather expend their time and energy on the sexier thing, the more obviously lucrative thing. And who could blame them? But that tends to take you along a less interesting route

There’s something powerful about allowing yourself to fully, obsessively love something that makes no sense. And it’s so contrary to how we’re told to live our lives. Identify and capture value! Go into the field where the best jobs are! Marry someone who is reliable! I’m not saying that’s bad advice—it’s good advice from many a perspective—but I also feel like I’ve stumbled into everything meaningful in my life when I was just like, hey, I’ll just give this a shot and it definitely won’t work.

seriously, some of the best cinema is in pornography. If you ignore the money shots, like Bijou by Wakefield Poole, it’s psychedelic gay porn, and it’s just remarkable. It’s interesting because, starting off with the ’90s, there was a pantheon, and there still is a pantheon, so Bergman and Fassbinder, they were at the top of the National Film Theater, as it was called back then, which showed Italian horror, it was on the trash heap. And now, of course, it’s high up because of Mr Luca and his film. So I’m waiting for pornography to get to that, maybe he’ll do a remake of Bijou, I don’t know. I always enjoyed films which were seen as disreputable. There was always okay, this is interesting, let’s look for the trash. I think part of the filmmaker’s job is to be a bit like a vulture, a scavenger, to find things that people would turn their noses up at. So I think you can find great filmmaking anywhere.

Yes, it's something you'll need to cure, but while they're occurring, it's much like being sick with a cold. You don't get mad at yourself for sneezing, so you shouldn't try to fight your thoughts or see them as a bad part of your personality while you're still dealing with your disorder.

Acceptance is crucial. These thoughts are not in your control, and not something you should expect to control. Learn to accept that they're a natural part of the disorder and that when you treat your disorder you'll have fewer of these thoughts.

The MacBook Pro with M1 (from $1,299) is a laptop with an unbeatable combo of power and endurance, making it a fantastic laptop even now it's been surpassed by the MacBook Pro with M2. And I know this because I’ve been using this system for months to plow through my workload, and I can barely get this machine to stutter no matter what I throw at it.Thanks to the M1 chip, the Apple Silicon inside this 3-pound beast runs circles around most Windows laptops when it comes to sheer performance. Just as important, the new MacBook Pro M1 outlasts the competition on battery life — by a lot. We’re talking more than 16 hours of endurance. My only complaint is that Apple hasn’t touched the design.

When we talk about exclamation points, people often think we’re talking about tone. But what goes unsaid is that tone is the performance of niceness or seriousness. It is the work of matching sentence structure to gender norms, industry norms, workplace norms, and generational norms. It is switching norms dozens if not hundreds of times a day, as you shift from text to email, from group chat to professional Teams Message. And we are doing this Tone Work exponentially more than at any point in history.

Tone Work is not new. But technological advances that promised to allow us to communicate more efficiently have, in practice, also allowed us to communicate more, and created an expectation that all others communicate more in return. Hence: overflowing email accounts, proliferating group texts (and group text guilt), hours if not days dedicated to catching up on Slack. Dealing with that communication is exhausting, in part because it involves so much tone work.

I started grading, which meant I had to figure out the “compliment sandwich” at the end of the essay. The first sentence would start with praise, then an em-dash, then the real news: what needed work. A short list of things to refine, ending with encouragement, almost always capped with an exclamation point. This is a fantastic first draft, and I look forward to seeing the second! An embodiment of my teaching style, really: I’m so happy you’re here, I want us to talk seriously about how to become better writers and thinkers, but I also don’t ever want you to leave a conversation or class or piece of feedback from me feeling like shit.

If you think someone’s written communication style is off, or wrong, or bitchy: see if it’s possible to clarify their intention without asking them to change their tone.

When you observe a human life from a far enough distance, all the trials and tribulations just become rounding errors.

Dostoyevsky said that to love someone means to see them as God intended, so why on earth shouldn’t you also be a ‘someone’? This makes me think that sometimes you have to try to look at yourself through the eyes of God: how tiny and lacking, yet how precious and important; how flawed and powerless, yet unique and loved.

There’s something very calming about believing that nobody cares about what you do, that you could just be whatever you want to be. It grants you a kind of unlimited confidence, like flooring the gas pedal on your free will. It’s liberating to think that you’re not special — not because you aren’t valuable, but because you aren’t as offensively powerful as you might think. Humility, or the simple act of focusing less on yourself without reducing your sense of self-worth, can be the ultimate source of peace.

I want to see, in hindsight, that misfortunes haven’t hardened my heart — I want to look back and see a survivor. I want to see that heartaches have not smothered my passion and that sadness was not able to keep me down for long.

You may be existentially “trapped” in the present, but your perspective doesn’t have to be. With enough distance from your own timeline, every mistake blurs into a minor miscalculation, and every letdown diminishes to insignificance. Even a bad memory, with enough time, will appear trivial — it might transform you but its colors will fade into a wistful sepia.

Hassabis pointed to the example of AlphaFold, DeepMind’s machine-learning system that had predicted the structures of 200mn proteins, creating an invaluable resource for medical researchers. Previously, it had taken one PhD student up to five years to model just one protein structure. DeepMind calculated that AlphaFold had therefore saved the equivalent of almost 1bn years of research time.

DeepMind, and others, are also using AI to create new materials, discover new drugs, solve mathematical conjectures, forecast the weather more accurately and improve the efficiency of experimental nuclear fusion reactors. Researchers have been using AI to expand emerging scientific fields, such as bioacoustics, that could one day enable us to understand and communicate with other species, such as whales, elephants and bats.

Now researchers report that they have used artificial intelligence to discover a new class of antibiotic candidates. A team at the laboratory of James Collins of the Broad Institute of the Massachusetts Institute of Technology and Harvard University used a type of AI known as deep learning to screen millions of compounds for antibiotic activity. They then tested 283 promising compounds in mice and found several that were effective against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci—some of the most stubbornly hard-to-kill pathogens. Unlike a typical AI model, which operates as an inscrutable “black box,” it was possible to follow this model’s reasoning and understand the biochemistry behind it.

Although impression management has been relatively free of controversy as a scholarly topic, some disagreements have formed around the ethics of managing impressions, how to best measure impression management, and whether impression management explains some of the more venerable topics in social science such as prosocial behavior, cognitive dissonance, and moral judgment.

Other work has investigated how easy it is to mismanage an impression, such as when “humble bragging” and giving “backhanded compliments.”

One key problem across the apps is the slog of self-presentation, or “impression management,” said Rachel Katz, a digital media sociologist who studies online dating at the University of Salford in the UK. “An important aspect of it is knowing your audience,” Katz said. On dating apps, you don’t know who exactly you’re presenting yourself to when picking a profile picture or composing your bio. You also don’t have physical cues that can help you adjust that self-presentation. “You’re trying to come up with something that’s generally appealing to people, but it can’t be too weird. It can’t be too unique,” said Bryce. “That’s partly why it’s exhausting,” Katz explains, “because it’s this constant labor. ... You’re not really sure of how to do it, you can’t just fit into a comfortable social role.”

When dating apps are not delivering on compatibility, Dean said, they are leading you to “believe that there’s a forever volume of people you can always like.”

Ury rejects the notion that apps should be asking people for more about themselves in writing or through extensive questionnaires. Users may match up on paper but end up disappointed in real life. “I would have rather that people understand that sooner by meeting up earlier,” she said. “Use the app as a matchmaker who gives you the matches — and then, as quickly as possible, the two of you should be chatting live to see if you are a match,” she said. “We found that three days of chatting is the sweet spot for scheduling a date.”

It’s the longest in-depth longitudinal study on human life ever done, and it’s brought us to a simple and profound conclusion: Good relationships lead to health and happiness. The trick is that those relationships must be nurtured.

You don’t have to examine scientific findings to recognize that relationships affect you physically. All you have to do is notice the invigoration you feel when you believe that someone has really understood you during a good conversation, or the tension and distress you feel after an argument, or how little sleep you get during a period of romantic strife.

We don’t always know why we do things or why we don’t do things, and we may not understand what is holding us at a distance from the people in our life. Taking some time to look in the mirror can help. Sometimes there are needs inside of us that are looking for a voice, a way to get out. They might be things that we have never seen or articulated to ourselves.

Those who reported being lonelier had a greater chance of facing mental-health issues, partaking in unsafe physical-health behaviors, and coping with stress in negative ways. Add to this the fact that a tide of loneliness is flooding through modern societies, and we have a serious problem.

One person might have a significant other and too many friends to count and yet feel lonely, while another person might live alone and have a few close contacts and yet feel very connected. The objective facts of a person’s life are not enough to explain why someone is lonely. Regardless of your race or class or gender, the feeling resides in the difference between the kind of social contact you want and the social contact you actually have.

Repeatedly, when the participants in our study reached old age, they would make a point to say that what they treasured most were their relationships.

Relationships keep us happier and healthier throughout our life spans. We neglect our connections with others at our peril. Investing in our social fitness is possible each day, each week of our lives. Even small investments today in our relationships with others can create long-term ripples of well-being.

You will meet some people in your life who are your soulmate in an alternate universe. Don’t cause an incursion. Appreciate how they are doing in the other reality.

A top indicator of relationship success will be if you can successfully share a bathroom together.

The quarter life crisis is overrated. If you’re worried about your life at 25…stop. Whatever you experience between age 25 to 32 probably does not matter at all.

“If you want to build a ship, don’t drum up people to collect wood and don’t assign them tasks and work, but rather teach them to long for the endless immensity of the sea."— Antoine de Saint Exupéry